Special Issue "Fitness, Fate and Opportunities in Cancer Evolution"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 228

Special Issue Editor

Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA
Interests: tumorigenesis; metastasis; treatment resistance; evolutionary mechanisms

Special Issue Information

Dear Colleagues,

Over the past few decades, scientists and clinicians have uncovered fundamental features of cancer evolution. For example, cancer is driven by genetic mutations and other molecular alterations that confer a selective growth advantage. We have also discovered that tumors are dynamic ecosystems in which cancer cells interact with each other, the stroma, the immune system, and the microenvironment. Although evolutionary theory has illuminated cancer biology, many onco-evolutionary processes remain obscure. Which molecular mechanisms—including genetic, epigenetic, proteomic, metabolic, microenvironmental, and others—impact cancer cell fitness? What are the environmental conditions that determine the fate of a cancer cell lineage? Can we identify therapeutic opportunities arising from cancer evolutionary dynamics?

Our scientific tactics continue to evolve as well. The next generation of studies will utilize interdisciplinary approaches as well as novel technologies and models to delineate cancer evolution. For this Special Issue, we welcome both original research articles and reviews that focus on the cancer evolution of any tumor type, stage, organism, or model. The goals are to diversify our scientific approaches, increase our evolutionary knowledge, and to ultimately improve how we diagnose and treat patients.

Dr. Alvin Makohon-Moore
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer evolution
  • heterogeneity
  • fitness
  • microenvironments
  • pre-cancerous lesions
  • carcinogenesis
  • metastasis

Published Papers

This special issue is now open for submission.
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