Special Issue "Multiple Myeloma and Bone Marrow Microenvironment"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 225

Special Issue Editors

1. Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, 47014 Meldola, Italy 2. President of Society of Hematologic Oncology (SOHO), Italy
Interests: acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndromes; multiple myeloma and MGUS; non-Hodgkin and Hodgkin lymphoma
Special Issues, Collections and Topics in MDPI journals
Medical Director at UOC CTMO Hematology and Oncology, Hospital Regional Cagliari, Cagliari, Italy
Interests: ixazomib; lenalidomide; multiple myeloma
Prof. Dr. Alessandro Isidori
E-Mail Website
Guest Editor
Ematologia e Centro Trapianti di Midollo Osseo, Azienda Ospedaliera Ospedali Riuniti Marche Nord (AORMN), Pesaro, Italy
Interests: leukemia; immunotherapy

Special Issue Information

Dear Colleagues,

Multiple myeloma (MM) comprises a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. It accounts for approximately 1.8% of all hematologic and solid cancers and > 15% of hematologic malignancies in the United States. MM is typically sensitive to different classes of cytotoxic drugs, both as frontline treatment and as treatment for relapsed disease. Unfortunately, even if responses are typically durable, nowadays, MM is not considered curable with the current approaches.

However, MM survival rates have significantly improved due to the introduction of novel agents; patients diagnosed after 2010 have reported higher rates of novel therapy use and better survival outcomes compared with those of earlier years. The most relevant therapeutic advances over the past few decades have been the introduction of novel therapies, such as immune-modifying agents (thalidomide and lenalidomide) and proteasome inhibitors (bortezomib), with or without stem cell transplantation.

Moreover, in the last few years, the MM therapeutic “toolbox” has shown further improvement with the approval of new generation IMID (pomalidomide), the monoclonal antibodies daratumumab and elotuzumab, as well as the new-generation proteasome inhibitors carfilzomib and ixazomib.

At the same time, our understanding of MM tumor biology is increasing, creating the rationale for new combinations of drugs and new therapy development. Discovery of the associated cytogenetic abnormalities confirm the hypothesis that MM is a heterogeneous disease, suggesting that risk-adapted therapies and individualized treatment will help to further improve patient management.

However, patients with triple-class refractory MM, whose cells exhibit triple-class resistance to PIs, immunomodulatory drugs (IMiDs), and monoclonal antibodies (MoAb), continue to have an OS of < 6 months, emphasizing the urgency of this unmet medical need.

Drug resistance in MM patients needs to be deeply studied, and it can occur via intrinsic and extrinsic mechanisms, including intraclonal heterogeneity, drug efflux pumps, alterations of drug targets, the inhibition of apoptosis, increased DNA repair and interactions with the bone marrow (BM) microenvironment, cell adhesion, and the release of soluble factors.

MM–BM microenvironment interactions could play an important role, particularly due to the cross-talk between BM stromal cells, adipocytes, osteoclasts, osteoblasts, endothelial cells, and immune cells. Considering these complex mechanisms that drive MM, next-generation treatments that potentially avoid drug resistance must target both the neoplastic clone and its non-malignant environment.

Moreover, it is important to better define the role of cancer stem cells in the development of the disease, patient relapse, and drug resistance to improve disease management, particularly in heavily pretreated patients.

In fact, overcoming inherent and acquired drug resistance of MM cells, especially in the context of the immunosuppressive tumor microenvironment, remains a major challenge in the implementation of effective therapy of high-risk or relapsed/refractory myeloma.

We welcome the submission of original research, review, clinical trial, hypothesis and theory, and opinion articles.

Dr. Claudio Cerchione
Dr. Daniele Derudas
Prof. Dr. Alessandro Isidori
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • multiple myeloma (MM)
  • hematologic malignancies
  • cancer stem cells
  • relapsed myeloma
  • refractory myeloma
  • bone marrow (BM) microenvironment

Published Papers

There is no accepted submissions to this special issue at this moment.
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