Special Issue "Neurodegeneration in Developmental and Neoplastic Disorders of the Nervous System"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (30 June 2016) | Viewed by 33637
2. Faculty at Columbia University Medical Center, Scientist, Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, NY, USA
Interests: endocannabinoids; synaptic plasticity; FASD; AUD; neurodegeneration; learning and memory; epigenetics; gene expression; behavior
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The mechanisms which direct the important stages of brain development to orchestrate functional synaptic structure are gradually being elucidated. However, the mechanisms that regulate synaptic stability and neuronal loss that result in lifelong neurobehavioral outcome are not well known. Synapse loss is an early and invariant characteristic of many neurodegenerative diseases and in many cases the level of synapse loss correlates with the severity of the disease. The gestational and postnatal developments are appearing to be particularly vital for making stable neuronal connections that shape a lifetime of experience. The influence of environmental factors including drugs of abuse, exposure to toxicants, diet, and stress during gestation or early to late postnatal development have the ability to alter brain development and synaptic plasticity, resulting in lifelong intellectual disability and cognitive deficits. Hence, understanding the neurobehavioral mechanisms that underlie neurodegeneration and synaptic plasticity is crucial to understand the potential targets that will allow the development of therapies to protect synapses and improve neurobehavioral outcome.
The current Special Issue is aimed to collect a selected number of articles that demonstrate deeper insight in these topics, which bring both sound scientific and public health impacts.
Dr. Balapal S. Basavarajappa
Manuscript Submission Information
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- Drugs of abuse
- Environmental toxicants
- Molecular mechanisms
- Early brain development
- Synaptic plasticity
- Intellectual disability
- Cognitive deficits
- Learning and memory