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Brain Sciences
Special Issues
Cannabinoids, Brain and Pain: Novel Perspectives and Understandings
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Cannabinoids, Brain and Pain: Novel Perspectives and Understandings

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuroscience of Pain".

Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 1446

Special Issue Editor

Dr. Sascha Tafelski

E-Mail Website
Guest Editor
Department of Anesthesiology and Operative Intensive Care Medicine, Charité – Uni-verstätsmedizin Berlin, Berlin, Germany
Interests: chronic pain; phantom pain; neuropathic pain; transcranial direct current stimulation; analgesics

Special Issue Information

Dear Colleagues,

Cannabinoids facilitate a wide spectrum of pharmacological responses in experimental studies in animals and humans. Translational clinical studies have suggested potential benefits in different clinical conditions, including pain syndromes, spasticity, psychiatric disorders, and distinct epileptic diseases. Cannabinoids are also in medical use to improve symptoms such as inappetence, nausea and vomiting, and sleep disorders, exemplarily in palliative care. However, despite the availability of synthetic drugs and medical use, there is still a significant lack of evidence regarding the effectivity and effectiveness of cannabinoid treatment. Additionally, the side effects of cannabinoids, such as cognitive or cardiovascular dysfunction and addiction, are the topics of ongoing studies in the field.

Therefore, this Special Issue of Brain Sciences focuses on translational and clinical trials on cannabinoids to improve our understanding of cannabinoid treatment in clinical care. Researchers are welcome to submit manuscripts of translational experimental or clinical research.

Dr. Sascha Tafelski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cannabinoids
  • tetrahydrocannabinol
  • cannabidiol
  • chronic pain
  • spasticity
  • palliative care
  • inappetence
  • neuropathic pain

Published Papers (1 paper)

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Research

12 pages, 849 KiB  
Article
Influence of Cannabinoid Treatment on Trajectories of Patient-Related Outcomes in Chronic Pain: Pain Intensity, Emotional Distress, Tolerability and Physical Disability
by Anna Marie Balestra, Katharina Chalk, Claudia Denke, Nashwan Mohammed, Thomas Fritzsche and Sascha Tafelski
Brain Sci. 2023, 13(4), 680; https://doi.org/10.3390/brainsci13040680 - 19 Apr 2023
Cited by 1 | Viewed by 1108
Abstract
The treatment of chronic pain with cannabinoids is becoming more widespread and popular among patients. However, studies show that only a few patients experience any benefit from this treatment. It also remains unclear which domains are affected by cannabinoid treatment. Therefore, the present [...] Read more.
The treatment of chronic pain with cannabinoids is becoming more widespread and popular among patients. However, studies show that only a few patients experience any benefit from this treatment. It also remains unclear which domains are affected by cannabinoid treatment. Therefore, the present study is novel in that it explores the effects of cannabinoid treatment on four patient-related outcome measures (PROMs), and includes patients with chronic refractory pain conditions who have been given the option of cannabinoid treatment. A retrospective design was used to evaluate the impact of cannabinoid treatment on patients with refractory pain in two German outpatient pain clinics. The present study shows that pain intensity (mean relative reduction (−14.9 ± 22.6%), emotional distress (−9.2 ± 43.5%), pain-associated disability (−7.0 ± 46.5%) and tolerability of pain (−11 ± 23.4%)) improved with cannabinoid treatment. Interestingly, the trajectories of the PROMs seemed to differ between patients, with only 30% of patients responding with respect to pain intensity, but showing improvements in other PROMs. Although the mean treatment effects remained limited, the cumulative magnitude of change in all dimensions may affect patients’ quality of life. In summary, a singular evaluation with pain intensity as the sole outcome does not cover the multidimensional effects of cannabinoids. Therefore, the treatment effects of cannabinoids should be evaluated with different PROMs. Full article
(This article belongs to the Special Issue Cannabinoids, Brain and Pain: Novel Perspectives and Understandings)
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