Cognitive Health in Individuals with Multiple Sclerosis

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 1842

Special Issue Editors

Multiple Sclerosis Center, AHEPA, 2nd Neurological University Department, General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: neuroimmunology; neurodegenerative diseases; multiple sclerosis; neuroimaging; biomarkers; cognitive neuropsychology
Special Issues, Collections and Topics in MDPI journals
Multiple Sclerosis Center, 2nd Department of Neurology, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Interests: neuroimaging; cognition disorders; multiple sclerosis; neuroimmunology
Special Issues, Collections and Topics in MDPI journals
Multiple Sclerosis Center, AHEPA, 2nd Neurological University Department, General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: neuroimmunology; neurodegenerative diseases; multiple sclerosis; neuroimaging; biomarkers; cognitive neuropsychology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

People with Multiple Sclerosis (MS) often experience alterations in their cognitive abilities, including, but not limited to, information processing speed, memory and attention. Cognitive assessment tools, advanced neuroimaging techniques and non-pharmacological interventions are rapidly evolving fields of research aiming to facilitate the management and/or prevention of cognitive decline in the context of MS.

This Special Issue of Brain Sciences seeks commentaries, original research, short reports, and reviews focusing on the challenges in detecting, monitoring, and managing cognitive decline in MS. This Special Issue aims to provide information about advances in the research of cognitive assessment and the development of measurements for the early detection of cognitive impairment, neuroimaging and the overall impact of cognitive impairment in MS.

Dr. Marina Kleopatra Boziki
Dr. Christos Bakirtzis
Prof. Dr. Nikolaos Grigoriadis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimaging
  • cognitive neuropsychology
  • neuropsychological assessment
  • cognition disorders
  • neuroimmunology

Published Papers (2 papers)

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Research

12 pages, 1063 KiB  
Article
On the Move: Correlation of Impaired Mobility with Spatial Navigation Ability in Persons with Multiple Sclerosis
by Alexis N. Chargo, Taylor N. Takla, Nora E. Fritz and Ana M. Daugherty
Brain Sci. 2024, 14(3), 277; https://doi.org/10.3390/brainsci14030277 - 14 Mar 2024
Viewed by 426
Abstract
Spatial navigation ability is essential for independent living, and it relies on complex cognitive and motor processes that are vulnerable to decline in persons with multiple sclerosis (pwMS). The role of mobility in the physical act of navigation has been well documented; however, [...] Read more.
Spatial navigation ability is essential for independent living, and it relies on complex cognitive and motor processes that are vulnerable to decline in persons with multiple sclerosis (pwMS). The role of mobility in the physical act of navigation has been well documented; however, its association with cognitive processing that supports efficient navigation and recall of the environment is unknown. This study examined the relation between clinical mobility function and spatial navigation ability in pwMS. In a clinical sample of 43 individuals with relapsing-remitting MS (MPDDS = 2; age 25–67 years), we assessed spatial navigation ability in a virtual Morris water maze that allowed for active search by controlling a joystick while seated at a computer, and subsequent free recall of environment details. Individuals with worse mobility (measured by slower forward and backward walking) traveled less efficient virtual navigation routes to the goal location and recalled fewer accurate details of the environment. A stratified analysis by disability revealed moderate–strong correlations for those with a low level of disability, and effects were attenuated in individuals with a high level of disability. Given that the virtual navigation task was performed while seated, evidence of any correlation with mobility suggests differences in navigation ability that cannot be ascribed to general walking impairment, and instead suggests a role for mobility impairment to modify cognitive processing supporting navigation in pwMS. Full article
(This article belongs to the Special Issue Cognitive Health in Individuals with Multiple Sclerosis)
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15 pages, 287 KiB  
Article
Morphosyntactic Abilities and Cognitive Performance in Multiple Sclerosis
by Panagiotis Grigoriadis, Christos Bakirtzis, Elli Nteli, Marina-Kleopatra Boziki, Maria Kotoumpa, Paschalis Theotokis, Evangelia Kesidou and Stavroula Stavrakaki
Brain Sci. 2024, 14(3), 237; https://doi.org/10.3390/brainsci14030237 - 29 Feb 2024
Viewed by 849
Abstract
While cognitive abilities in people with multiple sclerosis (PwMS) have been studied in detail, little is known about linguistic abilities in PwMS and their relation to cognitive impairment. In this cross-sectional explorative study, we aim to investigate the morphosyntactic abilities of PwMS alongside [...] Read more.
While cognitive abilities in people with multiple sclerosis (PwMS) have been studied in detail, little is known about linguistic abilities in PwMS and their relation to cognitive impairment. In this cross-sectional explorative study, we aim to investigate the morphosyntactic abilities of PwMS alongside their cognitive performance. Furthermore, we explore the effect of clinical factors, namely, the disease duration and MS type, on the linguistic and cognitive performance of PwMS. By so doing, we aim to shed light on neurocognitive and clinical correlates of linguistic performance in PwMS. We included 78 patients and 78 age-, sex- and education-matched healthy individuals. All participants were additionally administered the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery, a verbal short-term memory task (non-word repetition) and questionnaires about mood, fatigue and quality of life. In addition, they underwent examinations with morphology and syntax tasks. PwMS were found to be impaired in morphology (past tense) and selectively impaired in syntax alongside cognitive impairments. Disease duration had the main impact on cognitive abilities. The MS type selectively impacted linguistic abilities, as shown by the remarkably deficient performance of the MS individuals with the progressive disease subtype. Linguistic impairments were predicted by only one measure of the BICAM test, namely, the Symbol Digit Modalities Test (SDMT), a measure of cognitive processing speed. Overall, this study contributes to the better understanding of the linguistic profile of PwMS by reporting selective deficits in their morphological and syntactical abilities. Furthermore, it provides insights into the clinical and cognitive correlates of linguistic performance. By so doing, it suggests clinical implications for the development of intervention programs for PwMS. Full article
(This article belongs to the Special Issue Cognitive Health in Individuals with Multiple Sclerosis)
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