Addiction and Neuroinflammation

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 1517

Special Issue Editors


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Guest Editor
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Interests: allostasis; arterial spin labeling; brain aging; migraine disorders; pain threshold; pulvinar; retinal vessels; sex dimorphism; sex dimorphism in alcoholism; thalamo-cortical network

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Guest Editor Assistant
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Interests: addiction; addiction recovery; allostasis; emotional regulation; salience network

Special Issue Information

Dear Colleagues,

Chronic and heavy alcohol consumption can significantly impact multiple organs in the body, particularly the brain, resulting in both acute and chronic inflammation. Alcohol-induced inflammation in brain cells can arise through various mechanisms, triggering an exaggerated immune response within the central nervous system. To gain a comprehensive understanding of these mechanisms, we encourage research papers that specifically explore the effects of long-term alcohol use on processes such as microglial activation, the release of pro-inflammatory cytokines, disruption of the blood–brain barrier, excessive oxidative stress, and neurodegeneration in the context of alcohol-related neuroinflammation. Additionally, we welcome studies that investigate the relationship between alcohol-related neuroinflammation and the heightened susceptibility to neurological disorders.

Dr. Nasim Maleki
Guest Editor

Dr. Benjamin Thompson
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • alcohol use disorder
  • alcoholism
  • alcohol abuse
  • alcohol dependence
  • inflammation
  • neuroinflammation
  • neurodegeneration
  • pro-inflammatory cytokines

Published Papers (1 paper)

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Research

14 pages, 1856 KiB  
Article
Nicotine, THC, and Dolutegravir Modulate E-Cigarette-Induced Changes in Addiction- and Inflammation-Associated Genes in Rat Brains and Astrocytes
by Jacqueline Renee Kulbe, Lauren Nguyen, Alexandra Anh Le, Anna Elizabeth Laird, Michael A. Taffe, Jacques D. Nguyen and Jerel Adam Fields
Brain Sci. 2023, 13(11), 1556; https://doi.org/10.3390/brainsci13111556 - 07 Nov 2023
Cited by 1 | Viewed by 1265
Abstract
E-cigarette use has been marketed as a safer alternative to traditional cigarettes, as a means of smoking cessation, and are used at a higher rate than the general population in people with HIV (PWH). Early growth receptor 2 (EGR2) and Activity-Regulated Cytoskeleton-Associated Protein [...] Read more.
E-cigarette use has been marketed as a safer alternative to traditional cigarettes, as a means of smoking cessation, and are used at a higher rate than the general population in people with HIV (PWH). Early growth receptor 2 (EGR2) and Activity-Regulated Cytoskeleton-Associated Protein (ARC) have a role in addiction, synaptic plasticity, inflammation, and neurodegeneration. This study showed that 10 days of exposure to e-cigarette vapor altered gene expression in the brains of 6-month-old, male, Sprague Dawley rats. Specifically, the e-cigarette solvent vapor propylene glycol (PG) downregulated EGR2 and ARC mRNA expression in frontal cortex, an effect which was reversed by nicotine (NIC) and THC, suggesting that PG could have a protective role against NIC and cannabis dependence. However, in vitro, PG upregulated EGR2 and ARC mRNA expression at 18 h in cultured C6 rat astrocytes suggesting that PG may have neuroinflammatory effects. PG-induced upregulation of EGR2 and ARC mRNA was reversed by NIC but not THC. The HIV antiretroviral DTG reversed the effect NIC had on decreasing PG-induced upregulation of EGR2, which is concerning because EGR2 has been implicated in HIV latency reversal, T-cell apoptosis, and neuroinflammation, a process that underlies the development of HIV-associated neurocognitive disorders. Full article
(This article belongs to the Special Issue Addiction and Neuroinflammation)
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