Special Issue "Brain-Microbiome Interactions II"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Environmental Neuroscience".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 74

Special Issue Editor

Co-Director of TGen Integrated Microbiomics Center, Research Assistant Professor, Pathogens and Microbiome Division, Translational Genomics Research Institute (TGen North), Flagstaff, AZ, USA
Interests: human microbiome; host-microbiome interactions; interspecies microbiome inter-actions; brain-gut axis; immunology; infectious diseases; chronic inflammatory diseases; glioblastoma; brain tumor; neurodegenerative disease; Alzheimer’s disease; autism spectrum disorder; cancer microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the great success of our Special Issue "Brain-Microbiome Interactions", we decided to set up a second volume: "Brain-Microbiome Interactions II".

Over the past decade, research on the human microbiome has made tremendous progress. Now we know that microbiomes are closely associated with digestive health, cardiovascular health, immune system development and regulation, nutrient production, protection against various pathogens, cancer development and treatment, and even our mental health. The gut-brain axis is a bi-directional communication system that connects the central nervous system (CNS) with the enteric nervous system (ENS). The microbiome and its metabolites can send signals to the brain through various pathways, including the immune system, the vagus nerve, and the release of neuroactive molecules. Likewise, the brain can influence the gut microbiome through the release of stress hormones and other neurotransmitters.

Current researches on the gut-brain axis focus on its role in disorders such as mental health, neurological disorders, and cancers. Researchers are exploring the link between the gut microbiome and diseases such as depression, Parkinson's disease, Alzheimer's disease, and glioma, with the goal of developing new treatments and interventions. Additionally, investigations into diet, stress, and personalized medicine are revealing potential applications for personalized dietary recommendations, microbiome-based treatments, and individualized health management strategies.

This Special Issue is to explore the composition and diversity of the gut microbiome and its role in influencing brain function, neurochemistry, and brain disease development, and to discuss how changes in microbiome composition can affect the gut-brain axis. Another purpose of this Special Issue is to explore the potential of microbiome-based interventions in treating gut-brain axis-related conditions.

We welcome the studies and reviews that help uncover the relationship between microbiome and brain disorders.

We invite you to read the Special Issue "Brain-Microbiome Interactions", which can be found at https://www.mdpi.com/journal/brainsci/special_issues/Brain_Microbio_Interact.

Dr. Keehoon Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gut-brain axis
  • microbiome
  • neurodegenerative disease, glioma
  • glioblastoma
  • cancer microbiome
  • autism spectral disorder
  • ASD
  • multiple sclerosis
  • MS
  • Alzheimer’s
  • Parkinson’s
  • mental health
  • behavioral disorder

Published Papers

This special issue is now open for submission.
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