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Recent Advances in Surface Plasmon Biosensors Employed for Diseases Diagnostic...
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Recent Advances in Surface Plasmon Biosensors Employed for Diseases Diagnostic and the Monitoring of Environmental Changes

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 7060

Special Issue Editors

Dr. Roland Hergenröder

E-Mail Website
Guest Editor
Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., 44139 Dortmund, Germany
Interests: new diagnostic methods; metabolomic; NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Victoria Shpacovitch

E-Mail Website
Guest Editor
Leibniz Institut für Analytische Wissenschaften-ISAS-e.V.; Bunsen-Kirchhoff-Straße 11, 44139 Dortmund, Germany
Interests: surface-plasmon resonance-based sensors; bio-conjugation and sensor surface functionalization; function of extracellular vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the role of surface plasmon resonance (SPR)-based sensors in disease diagnostics and for the monitoring of environmental changes. These two aspects of SPR sensor applications are often connected. Environmental changes, especially pollution, in many cases trigger initial pathological transformations leading to disease development. Thus, for both application types, it is important to develop highly sensitive as well as highly selective sensing platforms. Known as sensors with high sensitivity and versatility, SPR-based biosensing platforms represent a group of instruments, which can fit the criteria mentioned above. Therefore, the main goal of this Special Issue is to highlight the newest trends in the development and design of SPR-based sensing platforms resulting in the enhanced sensitivity and improved selectivity of analyte detection. Moreover, it is also important to demonstrate the power of SPR biosensors in dealing with the wide diversity of bio-analytes involved in disease development. Thus, this Special Issue aims to gather original research articles and reviews devoted to the application of SPR-based sensors for the monitoring of environmental changes and disease progression.   

Dr. Roland Hergenröder
Dr. Victoria Shpacovitch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surface plasmon resonance sensors
  • environmental pollution
  • disease diagnostics
  • biomarkers
  • pathogenic microorganisms

Published Papers (4 papers)

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Research

9 pages, 681 KiB  
Communication
Impact of Optical Cavity on Refractive Index Sensitivity of Gold Nanohole Arrays
by Maria A. Shokova and Vladimir E. Bochenkov
Biosensors 2023, 13(12), 1038; https://doi.org/10.3390/bios13121038 - 18 Dec 2023
Viewed by 1193
Abstract
Refractive index sensing based on surface plasmon resonance (SPR) is a highly efficient label-free technique for biomolecular detection. The performance of this method is defined by the dielectric properties of a sensing layer and its structure. Nanohole arrays in thin metal films provide [...] Read more.
Refractive index sensing based on surface plasmon resonance (SPR) is a highly efficient label-free technique for biomolecular detection. The performance of this method is defined by the dielectric properties of a sensing layer and its structure. Nanohole arrays in thin metal films provide good refractive index sensitivity but often suffer from a large resonance linewidth, which limits their broad practical application in biosensorics. Coupling the broad plasmon modes to sharp resonances can reduce the peak widths, but at the same time it can also degrade the sensitivity. Here, we use Finite-Difference Time Domain simulations to study the factors affecting the sensing performance of gold-silica-gold optical cavities with nanohole arrays in the dielectric and top metal layers. We demonstrate that by tuning resonator size and inter-hole spacing, the performance of the biosensor can be optimized and the figure of merit of the order of 5–7 is reached. Full article
(This article belongs to the Special Issue Recent Advances in Surface Plasmon Biosensors Employed for Diseases Diagnostic and the Monitoring of Environmental Changes)
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23 pages, 16178 KiB  
Article
The Employment of the Surface Plasmon Resonance (SPR) Microscopy Sensor for the Detection of Individual Extracellular Vesicles and Non-Biological Nanoparticles
by Nour Sharar, Konstantin Wüstefeld, Rahat Morad Talukder, Julija Skolnik, Katharina Kaufmann, Bernd Giebel, Verena Börger, Friedrich Nolte, Carsten Watzl, Frank Weichert, Roland Hergenröder and Victoria Shpacovitch
Biosensors 2023, 13(4), 472; https://doi.org/10.3390/bios13040472 - 12 Apr 2023
Cited by 2 | Viewed by 2012
Abstract
A wide-field surface plasmon resonance (SPR) microscopy sensor employs the surface plasmon resonance phenomenon to detect individual biological and non-biological nanoparticles. This sensor enables the detection, sizing, and quantification of biological nanoparticles (bioNPs), such as extracellular vesicles (EVs), viruses, and virus-like particles. The [...] Read more.
A wide-field surface plasmon resonance (SPR) microscopy sensor employs the surface plasmon resonance phenomenon to detect individual biological and non-biological nanoparticles. This sensor enables the detection, sizing, and quantification of biological nanoparticles (bioNPs), such as extracellular vesicles (EVs), viruses, and virus-like particles. The selectivity of bioNP detection does not require biological particle labeling, and it is achieved via the functionalization of the gold sensor surface by target-bioNP-specific antibodies. In the current work, we demonstrate the ability of SPR microscopy sensors to detect, simultaneously, silica NPs that differ by four times in size. Employed silica particles are close in their refractive index to bioNPs. The literature reports the ability of SPR microscopy sensors to detect the binding of lymphocytes (around 10 μm objects) to the sensor surface. Taken together, our findings and the results reported in the literature indicate the power of SPR microscopy sensors to detect bioNPs that differ by at least two orders in size. Modifications of the optical sensor scheme, such as mounting a concave lens, help to achieve homogeneous illumination of a gold sensor chip surface. In the current work, we also characterize the improved magnification factor of the modified SPR instrument. We evaluate the effectiveness of the modified and the primary version of the SPR microscopy sensors in detecting EVs isolated via different approaches. In addition, we demonstrate the possibility of employing translation and rotation stepper motors for precise adjustments of the positions of sensor optical elements—prism and objective—in the primary version of the SPR microscopy sensor instrument, and we present an algorithm to establish effective sensor–actuator coupling. Full article
(This article belongs to the Special Issue Recent Advances in Surface Plasmon Biosensors Employed for Diseases Diagnostic and the Monitoring of Environmental Changes)
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17 pages, 5374 KiB  
Article
Surface Plasmon Resonance Sensitivity Enhancement Based on Protonated Polyaniline Films Doped by Aluminum Nitrate
by Qais M. Al-Bataineh, Victoria Shpacovitch, Diyar Sadiq, Ahmad Telfah and Roland Hergenröder
Biosensors 2022, 12(12), 1122; https://doi.org/10.3390/bios12121122 - 03 Dec 2022
Cited by 7 | Viewed by 1402
Abstract
Complex composite films based on polyaniline (PANI) doped hydrochloric acid (HCl) incorporated with aluminum nitrate (Al(NO3)3) on Au-layer were designed and synthesized as a surface plasmon resonance (SPR) sensing device. The physicochemical properties of (PANI-HCl)/Al(NO3)3 complex [...] Read more.
Complex composite films based on polyaniline (PANI) doped hydrochloric acid (HCl) incorporated with aluminum nitrate (Al(NO3)3) on Au-layer were designed and synthesized as a surface plasmon resonance (SPR) sensing device. The physicochemical properties of (PANI-HCl)/Al(NO3)3 complex composite films were studied for various Al(NO3)3 concentrations (0, 2, 4, 8, 16, and 32 wt.%). The refractive index of the (PANI-HCl)/Al(NO3)3 complex composite films increased continuously as Al(NO3)3 concentrations increased. The electrical conductivity values increased from 5.10 µS/cm to 10.00 µS/cm as Al(NO3)3 concentration increased to 32 wt.%. The sensitivity of the SPR sensing device was investigated using a theoretical approach and experimental measurements. The theoretical system of SPR measurement confirmed that increasing Al(NO3)3 in (PANI-HCl)/Al(NO3)3 complex composite films enhanced the sensitivity from about 114.5 [Deg/RIU] for Au-layer to 159.0 [Deg/RIU] for Au-((PANI-HCl)/Al(NO3)3 (32 wt.%)). In addition, the signal-to-noise ratio for Au-layer was 3.95, which increased after coating by (PANI-HCl)/Al(NO3)3 (32 wt.%) complex composite layer to 8.82. Finally, we conclude that coating Au-layer by (PANI-HCl)/Al(NO3)3 complex composite films enhances the sensitivity of the SPR sensing device. Full article
(This article belongs to the Special Issue Recent Advances in Surface Plasmon Biosensors Employed for Diseases Diagnostic and the Monitoring of Environmental Changes)
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11 pages, 1933 KiB  
Article
Chitosan Micro-Membranes with Integrated Gold Nanoparticles as an LSPR-Based Sensing Platform
by Diana I. Meira, Manuela Proença, Rita Rebelo, Ana I. Barbosa, Marco S. Rodrigues, Joel Borges, Filipe Vaz, Rui L. Reis and Vitor M. Correlo
Biosensors 2022, 12(11), 951; https://doi.org/10.3390/bios12110951 - 01 Nov 2022
Cited by 7 | Viewed by 1623
Abstract
Currently, there is an increasing need to develop highly sensitive plasmonic sensors able to provide good biocompatibility, flexibility, and optical stability to detect low levels of analytes in biological media. In this study, gold nanoparticles (Au NPs) were dispersed into chitosan membranes by [...] Read more.
Currently, there is an increasing need to develop highly sensitive plasmonic sensors able to provide good biocompatibility, flexibility, and optical stability to detect low levels of analytes in biological media. In this study, gold nanoparticles (Au NPs) were dispersed into chitosan membranes by spin coating. It has been demonstrated that these membranes are particularly stable and can be successfully employed as versatile plasmonic platforms for molecular sensing. The optical response of the chitosan/Au NPs interfaces and their capability to sense the medium’s refractive index (RI) changes, either in a liquid or gas media, were investigated by high-resolution localized surface plasmon resonance (HR-LSPR) spectroscopy, as a proof of concept for biosensing applications. The results revealed that the lowest polymer concentration (chitosan (0.5%)/Au-NPs membrane) presented the most suitable plasmonic response. An LSPR band redshift was observed as the RI of the surrounding media was incremented, resulting in a sensitivity value of 28 ± 1 nm/RIU. Furthermore, the plasmonic membrane showed an outstanding performance when tested in gaseous atmospheres, being capable of distinguishing inert gases with only a 10−5 RI unit difference. The potential of chitosan/Au-NPs membranes was confirmed for application in LSPR-based sensing applications, despite the fact that further materials optimization should be performed to enhance sensitivity. Full article
(This article belongs to the Special Issue Recent Advances in Surface Plasmon Biosensors Employed for Diseases Diagnostic and the Monitoring of Environmental Changes)
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