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Biosensors
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Biosensors: Precision Medicine
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Biosensors: Precision Medicine

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 12117

Special Issue Editor

Prof. Dr. Michael Thompson

E-Mail Website
Guest Editor
Department of Chemistry, University of Toronto, Toronto, ON M5S 1A1, Canada
Interests: biosensor technology; acoustic wave detection; chemical sensors; biocompatibility; surface chemistry and analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am very pleased to invite you all to contribute to a Special Issue on the employment of biosensor detection technology in precision medicine. This area of medicine, which was emphasized by President Barack Obama in his 2015 State of the Union, has been growing rapidly in recent years. Precision medicine involves an attempt to orchestrate the treatment approaches taken on a medical basis with respect to the condition of a particular patient. The strategy involves choices for treatment based on a subpopulation of patents that display certain medical features. The main purposes of precision medicine lie in the potential ability of doctors, clinicians, and other members of the medical community to prevent disease in the first place, follow disease progression more efficiently, tailor drug treatment effectively, and enhance detection of disease. It is this last topic where the application of biosensor technology will prove to be extremely relevant and helpful in the field. A key element of disease detection, for example, is the quantitative assay of molecular and cellular biomarkers. This technology is critical in the diagnosis and monitoring of a specific medical condition with respect to initial detection, progression, and effect of drug treatment.

The Special Issue will be of interest to a very wide range of disciplines, such as bioanalytical chemistry, biology, clinical biochemistry, pharmaceutical science, and device detection technology including electrochemistry and optical and acoustic wave systems. The Special Issue plans not only to provide an overview on recent achievements but also to stimulate ideas about the current and future research on the application of biosensors in precision medicine. Both original papers and reviews are very welcome.

Prof. Dr. Michael Thompson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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14 pages, 2671 KiB  
Article
On-Chip Glucose Detection Based on Glucose Oxidase Immobilized on a Platinum-Modified, Gold Microband Electrode
by Julia Madden, Colm Barrett, Fathima R. Laffir, Michael Thompson, Paul Galvin and Alan O’ Riordan
Biosensors 2021, 11(8), 249; https://doi.org/10.3390/bios11080249 - 25 Jul 2021
Cited by 8 | Viewed by 3347
Abstract
We report the microfabrication and characterization of gold microband electrodes on silicon using standard microfabrication methods, i.e., lithography and etching techniques. A two-step electrodeposition process was carried out using the on-chip platinum reference and gold counter electrodes, thus incorporating glucose oxidase onto a [...] Read more.
We report the microfabrication and characterization of gold microband electrodes on silicon using standard microfabrication methods, i.e., lithography and etching techniques. A two-step electrodeposition process was carried out using the on-chip platinum reference and gold counter electrodes, thus incorporating glucose oxidase onto a platinum-modified, gold microband electrode with an o-phenylenediamine and ß-cyclodextrin mixture. The as-fabricated electrodes were studied using optical microscopy, scanning electron microscopy, and atomic force microscopy. The two-step electrodeposition process was conducted in low sample volumes (50 µL) of both solutions required for biosensor construction. Cyclic voltammetry and electrochemical impedance spectroscopy were utilised for electrochemical characterization at each stage of the deposition process. The enzymatic-based microband biosensor demonstrated a linear response to glucose from 2.5–15 mM, using both linear sweep voltammetry and chronoamperometric measurements in buffer-based solutions. The biosensor performance was examined in 30 µL volumes of fetal bovine serum. Whilst a reduction in the sensor sensitivity was evident within 100% serum samples (compared to buffer media), the sensor demonstrated linear glucose detection with increasing glucose concentrations (5–17 mM). Full article
(This article belongs to the Special Issue Biosensors: Precision Medicine)
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11 pages, 1386 KiB  
Article
Evaluation of the Diagnostic Accuracy of a New Biosensors-Based Rapid Diagnostic Test for the Point-Of-Care Diagnosis of Previous and Recent Dengue Infections in Malaysia
by Zhuo Lin Chong, Hui Jen Soe, Amni Adilah Ismail, Tooba Mahboob, Samudi Chandramathi and Shamala Devi Sekaran
Biosensors 2021, 11(5), 129; https://doi.org/10.3390/bios11050129 - 22 Apr 2021
Cited by 8 | Viewed by 2693
Abstract
Dengue is a major threat to public health globally. While point-of-care diagnosis of acute/recent dengue is available to reduce its mortality, a lack of rapid and accurate testing for the detection of previous dengue remains a hurdle in expanding dengue seroepidemiological surveys to [...] Read more.
Dengue is a major threat to public health globally. While point-of-care diagnosis of acute/recent dengue is available to reduce its mortality, a lack of rapid and accurate testing for the detection of previous dengue remains a hurdle in expanding dengue seroepidemiological surveys to inform its prevention, especially vaccination, to reduce dengue morbidity. This study evaluated ViroTrack Dengue Serostate, a biosensors-based semi-quantitative anti-dengue IgG (immunoglobulin G) immuno-magnetic agglutination assay for the diagnosis of previous and recent dengue in a single test. Blood samples were obtained from 484 healthy participants recruited randomly from two communities in Petaling district, Selangor, Malaysia. The reference tests were Panbio Dengue IgG indirect and capture enzyme-linked immunosorbent assays, in-house hemagglutination inhibition assay, and focus reduction neutralization test. Dengue Serostate had a sensitivity and specificity of 91.1% (95%CI 87.8–93.8) and 91.1% (95%CI 83.8–95.8) for the diagnosis of previous dengue, and 90.2% (95%CI 76.9–97.3) and 93.2% (95%CI 90.5–95.4) for the diagnosis of recent dengue, respectively. Its positive predictive value of 97.5% (95%CI 95.3–98.8) would prevent most dengue-naïve individuals from being vaccinated. ViroTrack Dengue Serostate’s good point-of-care diagnostic accuracy can ease the conduct of dengue serosurveys to inform dengue vaccination strategy and facilitate pre-vaccination screening to ensure safety. Full article
(This article belongs to the Special Issue Biosensors: Precision Medicine)
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Review

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13 pages, 1539 KiB  
Review
Applications of Microwave Energy in Medicine
by Alexandra Gartshore, Matt Kidd and Lovleen Tina Joshi
Biosensors 2021, 11(4), 96; https://doi.org/10.3390/bios11040096 - 26 Mar 2021
Cited by 40 | Viewed by 5097
Abstract
Microwaves are a highly utilized electromagnetic wave, used across a range of industries including food processing, communications, in the development of novel medical treatments and biosensor diagnostics. Microwaves have known thermal interactions and theorized non-thermal interactions with living matter; however, there is significant [...] Read more.
Microwaves are a highly utilized electromagnetic wave, used across a range of industries including food processing, communications, in the development of novel medical treatments and biosensor diagnostics. Microwaves have known thermal interactions and theorized non-thermal interactions with living matter; however, there is significant debate as to the mechanisms of action behind these interactions and the potential benefits and limitations of their use. This review summarizes the current knowledge surrounding the implementation of microwave technologies within the medical industry. Full article
(This article belongs to the Special Issue Biosensors: Precision Medicine)
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