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Special Issue "Paper-Based Biosensors for Biomedical Application"

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Division of Pharmacoengineering and Molecular Pharmaceutics, Therapeutic Biomaterials Laboratory, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Interests: diagnostic; biosensors; paper-based sensors; flexible sensors
Special Issues, Collections and Topics in MDPI journals

Dr. Ana Carolina Marques

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CENIMAT|i3N, Department of Materials Science, School of Science and Technology, NOVA University Lisbon and CEMOP/UNINOVA, 2829-516 Caparica, Portugal
Interests: biosensors; optical sensing; electrochemical sensing; laser-direct writing; laser-induced graphene; cellulose; paper

Special Issue Information

Dear Colleagues,

Paper-based biosensors show great potential for user-friendly diagnostics and sensors for various detection platforms. The development of flexible bioelectronics is very important for various biosensing approaches in biomedical engineering. This Special Issue will focus on original research articles, short communication and review articles covering paper-based biosensors for biomedical applications.

The development of paper-based biosensors using an integrated biological element, such as an enzyme, antibody, aptamer, whole cell, and tissue, as a biorecognition element are welcome.

This Special Issue welcomes contributions addressing, but not limited to, the following topics:

Paper-based biosensors for healthcare applications;
Advanced flexible sensor for gastrointestinal sensing;
LAMP-based paper biosensors for diagnostics;
Wearable sensors, devices, and electronics;
Enzymes on paper;
Advanced materials for sensing biomedical analytes.

Dr. Murali kannan Maruthamuthu
Dr. Ana Carolina Marques
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

paper-based sensors
diagnostics
biomedical sensors

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Research

Open AccessArticle

Super-Stable Metal–Organic Framework (MOF)/Luciferase Paper-Sensing Platform for Rapid ATP Detection

Héctor Martínez-Pérez-Cejuela

Maria Maddalena Calabretta

Valerio Bocci

Marcello D’Elia

and

Elisa Michelini

Biosensors 2023, 13(4), 451; https://doi.org/10.3390/bios13040451 - 01 Apr 2023

Cited by 2 | Viewed by 1608

Abstract

Adenosine triphosphate (ATP) determination has been used for many decades to assess microbial contamination for hygiene monitoring in different locations and workplace environments. Highly sophisticated methods have been reported, yet commercially available kits rely on a luciferase–luciferin system and require storage and shipping at controlled temperatures (+4 or −20 °C). The applicability of these systems is limited by the need for a secure cold chain, which is not always applicable, especially in remote areas or low-resource settings. In this scenario, easy-to-handle and portable sensors would be highly valuable. Prompted by this need, we developed a bioluminescence paper biosensor for ATP monitoring in which a new luciferase mutant was combined with a metal–organic framework (MOF); i.e., zeolitic imidazolate framework-8 (ZIF-8). A paper biosensor was developed, ZIF-8@Luc paper sensor, and interfaced with different portable light detectors, including a silicon photomultiplier (SiPM) and smartphones. The use of ZIF-8 not only provided a five-fold increase in the bioluminescence signal, but also significantly improved the stability of the sensor, both at +4 and +28 °C. The ATP content in complex biological matrices was analyzed with the ZIF-8@Luc paper sensor, enabling detection down to 7 × 10⁻¹² moles of ATP and 8 × 10⁻¹³ moles in bacterial lysates and urine samples, respectively. The ZIF-8@Luc sensor could, therefore, be applied in many fields in which ATP monitoring is required such as the control of microbial contamination. Full article

(This article belongs to the Special Issue Paper-Based Biosensors for Biomedical Application)

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Open AccessArticle

Eu-Chelate Polystyrene Microsphere-Based Lateral Flow Immunoassay Platform for hs-CRP Detection

and

Biosensors 2022, 12(11), 977; https://doi.org/10.3390/bios12110977 - 07 Nov 2022

Cited by 2 | Viewed by 1429

Abstract

Inflammation caused by viral or bacterial infection is a major threat to human health globally. Blood C-reactive protein (CRP) has been proven to be a sensitive indicator for the occurrence and development of inflammation. Furthermore, a tiny change of blood CRP concentration may portend chronic diseases; therefore, high-sensitivity CRP (hs-CRP) detection in a quantitative, rapid, user-friendly, and low-cost manner is highly demanded. In this paper, we developed a europium-chelate polystyrene microsphere (EuPSM)-based lateral flow immunoassay (LFIA) integrating with a benchtop fluorescence analyzer for hs-CRP detection. The optimization of the EuPSM-based LFIA was implemented through adjusting the antibody density on EuPSM from 100% to 60% of the saturated density. Finally, the limit of detection of 0.76 pg/mL and detection range of 0.025–250 ng/mL were obtained. Moreover, the clinical application capability of the proposed platform was validated through detecting CRP in clinical serum samples, showing high consistency with the results obtained from the clinical standard method. Hence, the proposed EuPSM-based LFIA has been verified to be well suitable for hs-CRP detection, while also showing great applicability for sensitively and rapidly detecting other biomarkers. Full article

(This article belongs to the Special Issue Paper-Based Biosensors for Biomedical Application)

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Special Issue "Paper-Based Biosensors for Biomedical Application"

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