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Biosensors
Special Issues
Recent Advances in Photonic Biosensors
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Recent Advances in Photonic Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 18823

Special Issue Editor

Dr. Nakkeeran Kaliyaperumal

E-Mail Website
Guest Editor
Senior Lecturer, School of Engineering, Fraser Noble Building, University of Aberdeen, Aberdeen AB15 9NH, UK
Interests: optical fibre sensors (fibre Bragg gratings and surface plasmon resonance); silicon photonics devices—design, modelling, simulation, analysis and their applications; modelling, simulation and analysis of semiconductor lasers and optical fibre lasers; optical microresonators—design, modelling, simulation, analysis and their applications; optical pulse compression and supercontinuum optical signal generation using optical fibres; coherent optical communication using nonlinear Fourier transform signal processing; design and applications of photonic crystal fibres (PCF) and photonic quasi crystal fibres (PQF); optical fibre communications using solitons and dispersion-managed solitons; nonlinear fibre optics modelling, simulation, analysis and their applications; integrability aspects of nonlinear partial differential equations
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to an upcoming Special Issue of Biosensors entitled “Recent Advances in Photonic Biosensors”. Recent research activity on this topic has led to the development of various applications in many fields including food safety control, clinical diagnostics, environmental monitoring, biosafety and biosecurity.

Presently, novel photonic biosensors based on state-of-art technologies, for instance, surface plasmon resonance (SPR), photonic crystal fibers (PCF) and photonic 2D materials, can deliver rapid, observable, label-free, and accurate detection of analytes such as proteins, antibodies, nucleic acids, and cells to measure biological, chemical, and physical signs of human health. Biosensors are also widely applied for the investigation of molecular kinetics under real-time monitoring. Therefore, photonic biosensors may be a promising tool for biochemical detection. Related commercial activities within this field have a large potential market and opportunities for these devices at the point-of-need.

The main aim of this Special Issue is to report on the recent developments and advances in the use of photonic biosensors to meet the demands of biochemical and biomedical analyses. Our objective is to introduce and highlight a collection of research and review articles that report the latest developments and trends in photonic biosensor design, characterization, analysis, and applications to a wide audience of applied mathematicians, physicists, biologists, medical research experts, chemists, and optical engineers who work in this area. We plan to not only provide an overview on recent achievements but also to stimulate current and future research in the photonic biosensors field. Both original papers and reviews are welcome.

Dr. Nakkeeran Kaliyaperumal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photonic biosensors
  • refractive-index-based biosensors
  • molecular kinetics
  • DNA/RNA–protein interactions
  • photonic crystal fiber (PCF) biosensors
  • surface plasmon resonance (SPR) biosensors
  • real-time monitoring
  • photonic 2D materials

Published Papers (4 papers)

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Research

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10 pages, 2435 KiB  
Article
Color-Coded Droplets and Microscopic Image Analysis for Multiplexed Antibiotic Susceptibility Testing
by Yunjin Jeong, Haewook Jang, Junwon Kang, Juhong Nam, Kyoungseob Shin, Sunghoon Kwon and Jungil Choi
Biosensors 2021, 11(8), 283; https://doi.org/10.3390/bios11080283 - 19 Aug 2021
Cited by 4 | Viewed by 3121
Abstract
Since the discovery of antibiotics, the emergence of antibiotic resistance has become a global issue that is threatening society. In the era of antibiotic resistance, finding the proper antibiotics through antibiotic susceptibility testing (AST) is crucial in clinical settings. However, the current clinical [...] Read more.
Since the discovery of antibiotics, the emergence of antibiotic resistance has become a global issue that is threatening society. In the era of antibiotic resistance, finding the proper antibiotics through antibiotic susceptibility testing (AST) is crucial in clinical settings. However, the current clinical process of AST based on the broth microdilution test has limitations on scalability to expand the number of antibiotics that are tested with various concentrations. Here, we used color-coded droplets to expand the multiplexing of AST regarding the kind and concentration of antibiotics. Color type and density differentiate the kind of antibiotics and concentration, respectively. Microscopic images of a large view field contain numbers of droplets with different testing conditions. Image processing analysis detects each droplet, decodes color codes, and measures the bacterial growth in the droplet. Testing E. coli ATCC 25922 with ampicillin, gentamicin, and tetracycline shows that the system can provide a robust and scalable platform for multiplexed AST. Furthermore, the system can be applied to various drug testing systems, which require several different testing conditions. Full article
(This article belongs to the Special Issue Recent Advances in Photonic Biosensors)
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12 pages, 10418 KiB  
Article
Nanofluidic Immobilization and Growth Detection of Escherichia coli in a Chip for Antibiotic Susceptibility Testing
by Jan F. Busche, Svenja Möller, Ann-Kathrin Klein, Matthias Stehr, Foelke Purr, Margherita Bassu, Thomas P. Burg and Andreas Dietzel
Biosensors 2020, 10(10), 135; https://doi.org/10.3390/bios10100135 - 25 Sep 2020
Cited by 4 | Viewed by 3563
Abstract
Infections with antimicrobial resistant bacteria are a rising threat for global healthcare as more and more antibiotics lose their effectiveness against bacterial pathogens. To guarantee the long-term effectiveness of broad-spectrum antibiotics, they may only be prescribed when inevitably required. In order to make [...] Read more.
Infections with antimicrobial resistant bacteria are a rising threat for global healthcare as more and more antibiotics lose their effectiveness against bacterial pathogens. To guarantee the long-term effectiveness of broad-spectrum antibiotics, they may only be prescribed when inevitably required. In order to make a reliable assessment of which antibiotics are effective, rapid point-of-care tests are needed. This can be achieved with fast phenotypic microfluidic tests, which can cope with low bacterial concentrations and work label-free. Here, we present a novel optofluidic chip with a cross-flow immobilization principle using a regular array of nanogaps to concentrate bacteria and detect their growth label-free under the influence of antibiotics. The interferometric measuring principle enabled the detection of the growth of Escherichia coli in under 4 h with a sample volume of 187.2 µL and a doubling time of 79 min. In proof-of-concept experiments, we could show that the method can distinguish between bacterial growth and its inhibition by antibiotics. The results indicate that the nanofluidic chip approach provides a very promising concept for future rapid and label-free antimicrobial susceptibility tests. Full article
(This article belongs to the Special Issue Recent Advances in Photonic Biosensors)
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Review

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35 pages, 6219 KiB  
Review
Immunosensing Based on Optical Fiber Technology: Recent Advances
by Maria Simone Soares, Miguel Vidal, Nuno F. Santos, Florinda M. Costa, Carlos Marques, Sónia O. Pereira and Cátia Leitão
Biosensors 2021, 11(9), 305; https://doi.org/10.3390/bios11090305 - 30 Aug 2021
Cited by 87 | Viewed by 7647
Abstract
The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where [...] Read more.
The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented. Full article
(This article belongs to the Special Issue Recent Advances in Photonic Biosensors)
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24 pages, 4366 KiB  
Review
State-of-the-Art Optical Microfiber Coupler Sensors for Physical and Biochemical Sensing Applications
by Maolin Dai, Zhenmin Chen, Yuanfang Zhao, Manthangal Sivanesan Aruna Gandhi, Qian Li and Hongyan Fu
Biosensors 2020, 10(11), 179; https://doi.org/10.3390/bios10110179 - 18 Nov 2020
Cited by 14 | Viewed by 3804
Abstract
An optical fiber coupler is a simple and fundamental component for fiber optic technologies that works by reducing the fiber diameter to hundred nanometers or several micrometers. The microfiber coupler (MFC) has regained interest in optical fiber sensing in recent years. The subwavelength [...] Read more.
An optical fiber coupler is a simple and fundamental component for fiber optic technologies that works by reducing the fiber diameter to hundred nanometers or several micrometers. The microfiber coupler (MFC) has regained interest in optical fiber sensing in recent years. The subwavelength diameter rationales vast refractive index (RI) contrast between microfiber “core” and surrounding “cladding”, a large portion of energy transmits in the form of an evanescent wave over the fiber surface that determines the MFC ultrasensitive to local environmental changes. Consequently, MFC has the potential to develop as a sensor. With the merits of easy fabrication, low cost and compact size, numerous researches have been carried out on different microfiber coupler configurations for various sensing applications, such as refractive index (RI), temperature, humidity, magnetic field, gas, biomolecule, and so on. In this manuscript, the fabrication and operation principle of an MFC are elaborated and recent advances of MFC-based sensors for scientific and technological applications are comprehensively reviewed. Full article
(This article belongs to the Special Issue Recent Advances in Photonic Biosensors)
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