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Biosensors
Special Issues
Emerging Nanoplasmonic Technologies in Biosensors
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Emerging Nanoplasmonic Technologies in Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 21330

Special Issue Editors

Dr. Maria Soler

E-Mail Website
Guest Editor
1. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
2. Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST and CIBER-BBN, 08193 Barcelona, Spain
Interests: nanophotonic sensing platforms; immunology; cell analysis; biosensors; bioengineering
Prof. Dr. Chia-Chen Chang

E-Mail Website
Guest Editor
Department of Medical Biotechnology and Laboratory Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Interests: plasmonic sensors; advanced biosensing technologies; functional nucleic acid sensors; single molecule sensors; chemical sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The detection of chemical and biochemical compounds is a topic that is currently attracting attention in environmental fields and the food and healthcare industries. It is driven by the idea of having innovative and high-performance analytical techniques. Over the last few decades, plasmonic sensors have been shown to possess advantages over and greater potential than the more traditional analytical methods and have opened up new horizons in biochemical analysis due to their capacity for label-free and real-time sensing. Recent developments, together with nanotechnology and nanoengineering, have boosted research in nanoplasmonic bioanalysis and created more advanced designs with increased sensitivities. Despite this progress, several challenges need to be overcome in order to improve nanoplasmonic biosensing technologies. These challenges include: (1) making the single-molecule analysis more sensitive; (2) developing a routine and high-throughput analysis; and (3) combining nanoplasmonic technologies with molecular identification techniques. Moreover, from an application perspective, the capacity to perform on-site analysis without skilled technicians and infrastructure is important to the detection community. In particular, affordable biosensing methods that provide a rapid response to small sample volumes may not only be of benefit to biomolecular analysis but also other fields, such as environmental surveillance and food safety.

To address these challenges, we welcome contributions to this Special Issue on the current state-of-the-art in plasmonic biosensing, with an emphasis on emerging analysis applications. Through a collection of original research papers and review articles, this Special Issue aims to raise awareness of these technologies in the field of bioanalysis and promote scientific collaboration across different research fields in order to resolve critical issues in nanoplasmonic biosensors. We strongly encourage the submission of manuscripts that focus on chemical analysis, such as innovative food safety testing, and biochemical analysis, such as frontier biosensing and molecular diagnosis. We welcome the submission of manuscripts that describe the development of new nanoplasmonic biosensing approaches for other kinds of analyses. We also welcome review papers presenting the status of, progress in, and remaining challenges for nanoplasmonic bioanalysis.

Potential topics include, but are not limited to:

  • on-site nanoplasmonic biosensor systems;
  • real-time biosensors;
  • single-molecule biosensors;
  • nanomaterials and nanostructures for biosensors;
  • nanoplasmon-enhanced optical biosensors;
  • applications in environmental and food monitoring;
  • applications to clinical and biochemical challenges;
  • novel concepts in biochemical sensors.

Dr. Maria Soler
Prof. Dr. Chia-Chen Chang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (5 papers)

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Research

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12 pages, 5097 KiB  
Article
Stable in Biocompatible Buffers Silver Nanoisland Films for SERS
by Alexey Skvortsov, Ekaterina Babich, Alexey Redkov, Andrey Lipovskii and Valentina Zhurikhina
Biosensors 2021, 11(11), 448; https://doi.org/10.3390/bios11110448 - 12 Nov 2021
Cited by 4 | Viewed by 1802
Abstract
We investigated the stability of silver nanoisland films, which were formed on glass surface by the method of out-diffusion, in biocompatible buffers and the applicability of the films in surface enhanced Raman scattering (SERS). We have shown that silver nanoisland films are stable [...] Read more.
We investigated the stability of silver nanoisland films, which were formed on glass surface by the method of out-diffusion, in biocompatible buffers and the applicability of the films in surface enhanced Raman scattering (SERS). We have shown that silver nanoisland films are stable in one of the most widespread in biological studies buffer—phosphate buffer saline (PBS), and in 1:100 water-diluted PBS, in the PBS-based buffer, in which NaCl is replaced by the same amount of NaClO4, and in acidic phosphate buffer. At the same time, the replacement of NaCl in PBS by N(CH3)4Cl leads to the degradation of the nanoislands. It was shown that after exposure to PBS the nanoisland films provided a good SERS signal from a monolayer of 1,2-di(4-pyridyl)ethylene (BPE), which makes silver nanoisland films promising for biosensor applications. Additionally, in our experiments, we registered for the first time that silver nanoparticles formed in the bulk of the samples dissolved after exposing to PBS, while nanoislands on the glass surface stayed unchanged. We associate this phenomenon with the interaction of ions contained in PBS solution with silver, which results in the shift of corresponding chemical equilibrium. Full article
(This article belongs to the Special Issue Emerging Nanoplasmonic Technologies in Biosensors)
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16 pages, 2905 KiB  
Article
Multi-Layer Reflectivity Calculation Based Meta-Modeling of the Phase Mapping Function for Highly Reproducible Surface Plasmon Resonance Biosensing
by Tzu-Heng Wu, Ching-Hsu Yang, Chia-Chen Chang, Hui-Wen Liu, Chia-Yu Yang, Tang-Long Shen, Chii-Wann Lin and Aurélien Bruyant
Biosensors 2021, 11(3), 95; https://doi.org/10.3390/bios11030095 - 23 Mar 2021
Cited by 3 | Viewed by 2796
Abstract
Phase-sensitive surface plasmon resonance biosensors are known for their high sensitivity. One of the technology bottle-necks of such sensors is that the phase sensorgram, when measured at fixed angle set-up, can lead to low reproducibility as the signal conveys multiple data. Leveraging the [...] Read more.
Phase-sensitive surface plasmon resonance biosensors are known for their high sensitivity. One of the technology bottle-necks of such sensors is that the phase sensorgram, when measured at fixed angle set-up, can lead to low reproducibility as the signal conveys multiple data. Leveraging the sensitivity, while securing satisfying reproducibility, is therefore is an underdiscussed key issue. One potential solution is to map the phase sensorgram into refractive index unit by the use of sensor calibration data, via a simple non-linear fit. However, basic fitting functions poorly portray the asymmetric phase curve. On the other hand, multi-layer reflectivity calculation based on the Fresnel coefficient can be employed for a precise mapping function. This numerical approach however lacks the explicit mathematical formulation to be used in an optimization process. To this end, we aim to provide a first methodology for the issue, where mapping functions are constructed from Bayesian optimized multi-layer model of the experimental data. The challenge of using multi-layer model as optimization trial function is addressed by meta-modeling via segmented polynomial approximation. A visualization approach is proposed for assessment of the goodness-of-the-fit on the optimized model. Using metastatic cancer exosome sensing, we demonstrate how the present work paves the way toward better plasmonic sensors. Full article
(This article belongs to the Special Issue Emerging Nanoplasmonic Technologies in Biosensors)
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12 pages, 2467 KiB  
Article
Biosensing Amplification by Hybridization Chain Reaction on Phase-Sensitive Surface Plasmon Resonance
by Ching-Hsu Yang, Tzu-Heng Wu, Chia-Chen Chang, Hui-Yun Lo, Hui-Wen Liu, Nien-Tsu Huang and Chii-Wann Lin
Biosensors 2021, 11(3), 75; https://doi.org/10.3390/bios11030075 - 06 Mar 2021
Cited by 9 | Viewed by 3272
Abstract
Surface Plasmon Resonance (SPR) is widely used in biological and chemical sensing with fascinating properties. However, the application of SPR to detect trace targets is hampered by non-specific binding and poor signal. A variety of approaches for amplification have been explored to overcome [...] Read more.
Surface Plasmon Resonance (SPR) is widely used in biological and chemical sensing with fascinating properties. However, the application of SPR to detect trace targets is hampered by non-specific binding and poor signal. A variety of approaches for amplification have been explored to overcome this deficiency including DNA aptamers as versatile target detection tools. Hybridization chain reaction (HCR) is a high-efficiency enzyme-free DNA amplification method operated at room temperature, in which two stable species of DNA hairpins coexist in solution until the introduction of the initiator strand triggers a cascade of hybridization events. At an optimal salt condition, as the concentrations of H1 and H2 increased, the HCR signals were enhanced, leading to signal amplification reaching up to 6.5-fold of the detection measure at 30 min. This feature enables DNA to act as an amplifying transducer for biosensing applications to provide an enzyme-free alternative that can easily detect complex DNA sequences. Improvement of more diverse recognition events can be achieved by integrating HCR with a phase-sensitive SPR (pSPR)-tested aptamer stimulus. This work seeks to establish pSPR aptamer system for highly informative sensing by means of an amplification HCR. Thus, combining pSPR and HCR technologies provide an expandable platform for sensitive biosensing. Full article
(This article belongs to the Special Issue Emerging Nanoplasmonic Technologies in Biosensors)
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Review

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23 pages, 4908 KiB  
Review
Plasmonic Biosensors for Single-Molecule Biomedical Analysis
by Elba Mauriz and Laura M. Lechuga
Biosensors 2021, 11(4), 123; https://doi.org/10.3390/bios11040123 - 15 Apr 2021
Cited by 30 | Viewed by 5331
Abstract
The rapid spread of epidemic diseases (i.e., coronavirus disease 2019 (COVID-19)) has contributed to focus global attention on the diagnosis of medical conditions by ultrasensitive detection methods. To overcome this challenge, increasing efforts have been driven towards the development of single-molecule analytical platforms. [...] Read more.
The rapid spread of epidemic diseases (i.e., coronavirus disease 2019 (COVID-19)) has contributed to focus global attention on the diagnosis of medical conditions by ultrasensitive detection methods. To overcome this challenge, increasing efforts have been driven towards the development of single-molecule analytical platforms. In this context, recent progress in plasmonic biosensing has enabled the design of novel detection strategies capable of targeting individual molecules while evaluating their binding affinity and biological interactions. This review compiles the latest advances in plasmonic technologies for monitoring clinically relevant biomarkers at the single-molecule level. Functional applications are discussed according to plasmonic sensing modes based on either nanoapertures or nanoparticle approaches. A special focus was devoted to new analytical developments involving a wide variety of analytes (e.g., proteins, living cells, nucleic acids and viruses). The utility of plasmonic-based single-molecule analysis for personalized medicine, considering technological limitations and future prospects, is also overviewed. Full article
(This article belongs to the Special Issue Emerging Nanoplasmonic Technologies in Biosensors)
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18 pages, 1680 KiB  
Review
Interfacing DNA with Gold Nanoparticles for Heavy Metal Detection
by Zhiyu He, Huiling Yin, Chia-Chen Chang, Guoqing Wang and Xingguo Liang
Biosensors 2020, 10(11), 167; https://doi.org/10.3390/bios10110167 - 06 Nov 2020
Cited by 23 | Viewed by 6995
Abstract
The contamination of heavy metals (e.g., Hg, Pb, Cd and As) poses great risks to the environment and human health. Rapid and simple detection of heavy metals of considerable toxicity in low concentration levels is an important task in biological and environmental analysis. [...] Read more.
The contamination of heavy metals (e.g., Hg, Pb, Cd and As) poses great risks to the environment and human health. Rapid and simple detection of heavy metals of considerable toxicity in low concentration levels is an important task in biological and environmental analysis. Among the many convenient detection methods for heavy metals, DNA-inspired gold nanoparticles (DNA-AuNPs) have become a well-established approach, in which assembly/disassembly of AuNPs is used for colorimetric signaling of the recognition event between DNA and target heavy metals at the AuNP interface. This review focuses on the recent efforts of employing DNA to manipulate the interfacial properties of AuNPs, as well as the major advances in the colorimetric detection of heavy metals. Beginning with the introduction of the fundamental aspects of DNA and AuNPs, three main strategies of constructing DNA-AuNPs with DNA binding-responsive interface are discussed, namely, crosslinking, electrostatic interaction and base pair stacking. Then, recent achievements in colorimetric biosensing of heavy metals based on manipulation of the interface of DNA-AuNPs are surveyed and compared. Finally, perspectives on challenges and opportunities for future research in this field are provided. Full article
(This article belongs to the Special Issue Emerging Nanoplasmonic Technologies in Biosensors)
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