Microfluidic Electrochemical Sensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (30 June 2022)

Special Issue Editors


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Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
Interests: biosensor; electrochemical; micro-nanofluidics; electro-kinetics
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Dipartimento di Chimica, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
Interests: biosensors; analytical chemistry; bioelectrochemisty; nanomaterials
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Visiting Research Scientist, New Jersey Institute of Technology, Newark, NJ, USA
Interests: microfluidics; electrochemical sensors; point-of-use devices; PFAS screening
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Special Issue Information

Dear Colleagues,

Electrochemical sensors offer a wide array of advantages with respect to the detection of various chemical and biological moieties. The detection of biomolecules, such as DNA or proteins, requires labeling, which may disrupt, alter, or modify the reaction properties, changing the assay outcome. Electrochemical sensors offer the advantage of label-free, sensitive, selective, low-cost, low-power, and real-time sensing. Electrochemical techniques, for example differential pulse voltammetry, linear sweep voltammetry, Square Wave Voltammetry, and Electrochemical Impedance Spectroscopy cyclic voltammetry, are notable for several factors, including generating no waste due to the usage of electrons for signal acquisition. The amalgamation of microfluidics with electrochemical sensors offers such advantages as precise control over the flow of the solution, multiplexing the detection system with multiple analytes on the same platform, automation of the process, and many more besides. For example, microfluidic electrochemical impedance-based biosensors can be implemented to develop point-of-care diagnostic devices that can be used for the prognosis of fatal conditions, such as myocardial infarctions, at an early stage. Additional applications include on-site detection of food-borne pathogens, biowarfare agent detection, and a point-of-use device for testing contaminants (chemical and biological) in environmental samples such as soil and water.

For this Special Issue, we invite original research articles and review papers on “Microfluidic Electrochemical Sensors” dedicated to cutting-edge research and innovation in building next-generation devices for the point-of-care diagnosis of diseases including COVID-19 and cancer and sensors for the detection of emerging contaminants, biothreats, and much more. This Special Issue will focus on applications including, but not limited to, medical diagnosis, global health, food safety, plant-based pathogens, and environmental monitoring.

Dr. Sagnik Basuray
Prof. Dr. Ilaria Palchetti
Dr. Charmi Chande
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • impedance biosensors
  • microfluidics biosensors
  • label-free-detection
  • point-of-care diagnosis
  • point-of-use devices

Published Papers (2 papers)

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Review

16 pages, 1030 KiB  
Review
Emerging Applications of Electrochemical Impedance Spectroscopy in Tear Film Analysis
by Berin Ozdalgic, Munire Gul, Zihni Onur Uygun, Nazente Atçeken and Savas Tasoglu
Biosensors 2022, 12(10), 827; https://doi.org/10.3390/bios12100827 - 05 Oct 2022
Cited by 3 | Viewed by 2582
Abstract
Human tear film, with a flow rate of 1–3 µL/min, is a rich bodily fluid that transmits a variety of metabolites and hormones containing proteins, lipids and electrolytes that provide clues about ocular and systemic diseases. Analysis of disease biomarkers such as proteins, [...] Read more.
Human tear film, with a flow rate of 1–3 µL/min, is a rich bodily fluid that transmits a variety of metabolites and hormones containing proteins, lipids and electrolytes that provide clues about ocular and systemic diseases. Analysis of disease biomarkers such as proteins, mRNA, enzymes and cytokines in the tear film, collected by noninvasive methods, can provide significant results for sustaining a predictive, preventive and personalized medicine regarding various diseases such as glaucoma, diabetic retinopathy, keratoconus, dry eye, cancer, Alzheimer’s disease, Parkinson’s disease and COVID-19. Electrochemical impedance spectroscopy (EIS) offers a powerful technique for analyzing these biomarkers. EIS detects electrical equivalent circuit parameters related to biorecognition of receptor–analyte interactions on the electrode surface. This method is advantageous as it performs a label-free detection and allows the detection of non-electroactive compounds that cannot be detected by direct electron transfer, such as hormones and some proteins. Here, we review the opportunities regarding the integration of EIS into tear fluid sampling approaches. Full article
(This article belongs to the Special Issue Microfluidic Electrochemical Sensors)
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14 pages, 2807 KiB  
Review
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
by Soojung Kim, Hyerin Song, Heesang Ahn, Taeyeon Kim, Jihyun Jung, Soo Kyung Cho, Dong-Myeong Shin, Jong-ryul Choi, Yoon-Hwae Hwang and Kyujung Kim
Biosensors 2021, 11(11), 412; https://doi.org/10.3390/bios11110412 - 22 Oct 2021
Cited by 20 | Viewed by 4443
Abstract
Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a [...] Read more.
Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities. Full article
(This article belongs to the Special Issue Microfluidic Electrochemical Sensors)
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