Microfluidics and MEMS for Diagnostics and Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (1 April 2024) | Viewed by 5262

Special Issue Editor

Special Issue Information

Dear Colleagues,

The recent pandemic has revealed the importance of innovation in healthcare as the best strategy for preparation for crises. Medical devices that target, in particular, point-of-care and low-resource healthcare settings become of paramount importance.

Recent advances in microfabrication, microfluidic and microelectromechanical systems (MEMS) technologies have opened numerous new avenues in health care applications. The ability to create complex nano-and micro-scale structures, employing various low-cost and biocompatible materials has enabled unrestricted geometrical features. In addition, the integration of sensing elements including electrical components (e.g., gold/silver/platinum/graphene-based electrodes), optical, wireless and data acquisition modules within the microfluidic network has attracted notable interest in medical device industry for health monitoring applications.

This special issue will highlight the new advances and trends in this prominent field and technology with an emphasis on the role of microfluidics and MEMS technologies in diagnostics and related medical applications and how the engineering principle can be used to meet industrial/clinical needs. In addition, the topic will highlight the challenges and opportunities of these biomedical devices.

We invite researchers working in this area to submit full-length research papers, communication, and review articles to meet the goal of this research topic.

Topics include:

  • Microfluidic design and simulation for microfluidic-based biomedical devices
  • Fabrication materials
  • Device fabrication techniques (e.g., lithography, soft lithography, micromachining, 3D printing, etc.)
  • MEMS-based medical devices
  • Rapid prototyping
  • Sensor integration
  • Vital signs monitoring
  • Implantable devices
  • Wearable devices
  • Drug delivery with microneedles and patches 

Dr. Qasem Ramadan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • microfabrication
  • microelectromechanical systems
  • diagnostics
  • biosensors
  • micromachining
  • integration
  • implantable
  • wearable

Published Papers (2 papers)

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Research

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19 pages, 2122 KiB  
Article
Development of a Microfluidic Chip Powered by EWOD for In Vitro Manipulation of Bovine Embryos
by Adriana Karcz, Ann Van Soom, Katrien Smits, Sandra Van Vlierberghe, Rik Verplancke, Osvaldo Bogado Pascottini, Etienne Van den Abbeel and Jan Vanfleteren
Biosensors 2023, 13(4), 419; https://doi.org/10.3390/bios13040419 - 25 Mar 2023
Cited by 3 | Viewed by 1862
Abstract
Digital microfluidics (DMF) holds great potential for the alleviation of laboratory procedures in assisted reproductive technologies (ARTs). The electrowetting on dielectric (EWOD) technology provides dynamic culture conditions in vitro that may better mimic the natural embryo microenvironment. Thus far, EWOD microdevices have been [...] Read more.
Digital microfluidics (DMF) holds great potential for the alleviation of laboratory procedures in assisted reproductive technologies (ARTs). The electrowetting on dielectric (EWOD) technology provides dynamic culture conditions in vitro that may better mimic the natural embryo microenvironment. Thus far, EWOD microdevices have been proposed for in vitro gamete and embryo handling in mice and for analyzing the human embryo secretome. This article presents the development of the first microfluidic chip utilizing EWOD technology designed for the manipulation of bovine embryos in vitro. The prototype sustains the cell cycles of embryos manipulated individually on the chips during in vitro culture (IVC). Challenges related to the chip fabrication as well as to its application during bovine embryo IVC in accordance with the adapted on-chip protocol are thoroughly discussed, and future directions for DMF in ARTs are indicated. Full article
(This article belongs to the Special Issue Microfluidics and MEMS for Diagnostics and Biomedical Applications)
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Review

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20 pages, 2892 KiB  
Review
Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers
by Seyedeh Rojin Shariati Pour, Donato Calabria, Afsaneh Emamiamin, Elisa Lazzarini, Andrea Pace, Massimo Guardigli, Martina Zangheri and Mara Mirasoli
Biosensors 2024, 14(1), 29; https://doi.org/10.3390/bios14010029 - 04 Jan 2024
Viewed by 2011
Abstract
Wearable biosensors are attracting great interest thanks to their high potential for providing clinical-diagnostic information in real time, exploiting non-invasive sampling of biofluids. In this context, sweat has been demonstrated to contain physiologically relevant biomarkers, even if it has not been exhaustively exploited [...] Read more.
Wearable biosensors are attracting great interest thanks to their high potential for providing clinical-diagnostic information in real time, exploiting non-invasive sampling of biofluids. In this context, sweat has been demonstrated to contain physiologically relevant biomarkers, even if it has not been exhaustively exploited till now. This biofluid has started to gain attention thanks to the applications offered by wearable biosensors, as it is easily collectable and can be used for continuous monitoring of some parameters. Several studies have reported electrochemical and optical biosensing strategies integrated with flexible, biocompatible, and innovative materials as platforms for biospecific recognition reactions. Furthermore, sampling systems as well as the transport of fluids by microfluidics have been implemented into portable and compact biosensors to improve the wearability of the overall analytical device. In this review, we report and discuss recent pioneering works about the development of sweat sensing technologies, focusing on opportunities and open issues that can be decisive for their applications in routine-personalized healthcare practices. Full article
(This article belongs to the Special Issue Microfluidics and MEMS for Diagnostics and Biomedical Applications)
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