Novel Biosensors as the Key Enablers for Telemedicine Revolution to Combat COVID-19

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Intelligent Biosensors and Bio-Signal Processing".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 10328

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Guest Editor
Texas Tech University Health Sciences Center (TTUHSC), Texas Tech University, Lubbock, TX 79409-3102, USA
Interests: low−power RF/Analog integrated circuits & system−on−a−Chip (SoC) design and test; interdisciplinary research on medical electronics; biosensors & biosignal processing
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Guest Editor
Department of Otolaryngology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Interests: head and neck surgery; speech and hearing sciences

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Guest Editor
Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
Interests: analog and mixed-signal integrated circuit design; biomedical integrated circuit design; biomedical engineering; wearable and implantable devices & sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the unprecedented COVID-19 pandemic, the field of telemedicine is undergoing a transformative change. The Centers for Medicare and Medicaid Services (CMS) in the US launched several emergency initiatives that have expanded Medicare and Medicaid coverage, including increasing the types of providers able to use telehealth, allowing providers more freedom to use remote patient monitoring and phone-based services, and expanding the number of sites qualifying for coverage to include homes, federally qualified health centers, and rural clinics. Furthermore, state regulators have added their own emergency directives.

As COVID-19 is highly contagious and the confirmed cases have already surpassed 24 million with over 180k deaths in the US alone, many hospitals have been severely overburdened and most are taking strict safety measures. The lack of proper personal protection equipment (PPE) and the inevitable donning-and-doffing errors often make healthcare workers (HCWs) particularly vulnerable to be infected by the SARS-CoV-2 virus. One popular idea is telemedicine triage. Some current programs can use audio-visual telemedicine platforms to arrange virtual visits. While telemedicine brings various benefits to both the patients and providers, there are also concerns, especially on the quality of care for virtual visits. For example, if a patient presents suspected symptoms of COVID-19, a telehealth provider would most likely not be able to listen to the patient’s lungs to evaluate signs of pneumonia nor take the patient’s vital signs remotely. There are also implications related to antimicrobial prescribing. Therefore, we believe new and sophisticated biosensors must be developed and deployed to improve the quality of care for combating the COVID-19 pandemic.

For example, monitoring patients’ vital signs in a hospital or clinic is essential but requires close patient contact during setup, adjustment, and/or monitoring, and the very high PPE burn rate has also forced HCWs to reuse masks, therefore placing HCWs at higher risks to COVID-19. One can reduce the setup time required for vital signs monitoring and minimize patient–clinician contact by developing novel non-contact remote vital signs sensors to considerably reduce the chances of HCW–patient cross-infections.

Telehealth has quickly emerged as the preferred care setting during the COVID-19 pandemic and will drive patient behavior in the future. From a patient standpoint, many will now see telehealth as their first point of contact for urgent care. For healthcare providers, it is also wise to use telehealth and mobile health (mHealth) tools more often as a first point of contact to assess what patients need. Providers have been trying out telemedicine platforms and mHealth devices. After learning how to manage patients with COVID-19, providers can then turn their attention to manage patients with chronic care needs and those newly discharged to their homes, which would also benefit considerably from smart biosensors for intelligent monitoring.

No longer are telemedicine services viewed as “nice to have”; they are now a must-have care delivery option in the post-COVID-19 era. Therefore, we believe there is an urgent need for the development and deployment of various novel biosensors to enable a telemedicine revolution to combat COVID-19. In conclusion, we would appreciate your valuable and timely contribution to this Special Issue.

Prof. Dr. Donald Y.C. Lie
Dr. Tam Q. Nguyen
Prof. Dr. Chung-Chih Hung
Guest Editors

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Published Papers (3 papers)

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Research

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17 pages, 4888 KiB  
Article
A Feasibility Study of Remote Non-Contact Vital Signs (NCVS) Monitoring in a Clinic Using a Novel Sensor Realized by Software-Defined Radio (SDR)
by Yang Liu, Clint Sweeney, Jill C. Mayeda, Jerry Lopez, Paul E. Lie, Tam Q. Nguyen and Donald Y. C. Lie
Biosensors 2023, 13(2), 191; https://doi.org/10.3390/bios13020191 - 27 Jan 2023
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Abstract
The COVID-19 outbreak has caused panic around the world as it is highly infectious and has caused about 5 million deaths globally. A robust wireless non-contact vital signs (NCVS) sensor system that can continuously monitor the respiration rate (RR) and heart rate (HR) [...] Read more.
The COVID-19 outbreak has caused panic around the world as it is highly infectious and has caused about 5 million deaths globally. A robust wireless non-contact vital signs (NCVS) sensor system that can continuously monitor the respiration rate (RR) and heart rate (HR) of patients clinically and remotely with high accuracy can be very attractive to healthcare workers (HCWs), as such a system can not only avoid HCWs’ close contact with people with COVID-19 to reduce the infection rate, but also be used on patients quarantined at home for telemedicine and wireless acute-care. Therefore, we developed a custom Doppler-based NCVS radar sensor system operating at 2.4 GHz using a software-defined radio (SDR) technology, and the novel biosensor system has achieved impressive real-time RR/HR monitoring accuracies within approximately 0.5/3 breath/beat per minute (BPM) on student volunteers tested in our engineering labs. To further test the sensor system’s feasibility for clinical use, we applied and obtained an Internal Review Board (IRB) approval from Texas Tech University Health Sciences Center (TTUHSC) and have used this NCVS monitoring system in a doctor’s clinic at TTUHSC; following testing on 20 actual patients for a small-scale clinical trial, we have found that the system was still able to achieve good NCVS monitoring accuracies within ~0.5/10 BPM across 20 patients of various weight, height and age. These results suggest our custom-designed NCVS monitoring system may be feasible for future clinical use to help combatting COVID-19 and other infectious diseases. Full article
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10 pages, 1213 KiB  
Article
A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
by Adil Ahmad Shahzad, Shafaq Mushtaq, Asim Waris, Syed Omer Gilani, Maha Abdallah Alnuwaiser, Mohammed Jameel and Niaz Bahadur Khan
Biosensors 2022, 12(6), 409; https://doi.org/10.3390/bios12060409 - 13 Jun 2022
Cited by 7 | Viewed by 2498
Abstract
Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the [...] Read more.
Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection of obstructive lung disease. This study was conducted on a total of 105 subjects, where 60 subjects were patients of obstructive lung disease and 45 subjects were healthy individuals. Patients were screened by means of the Pulmonary Function Test (PFT) by a pulmonologist. The gases present in the exhaled breath of all subjects were measured. The level of ammonia (32.29 ± 20.83 ppb), (68.83 ± 35.25 ppb), hydrogen sulfide (0.50 ± 0.26 ppm), (62.71 ± 22.20 ppb), and acetone (103.49 ± 35.01 ppb), (0.66 ± 0.31 ppm) in exhaled breath were significantly different (p < 0.05) between obstructive lung disease patients and healthy individuals, except alcohol, with a p-value greater than 0.05. Positive correlation was found between ammonia w.r.t Forced Expiratory Volume in 1 s (FEV1) (r = 0.74), Forced Vital Capacity (FVC) (r = 0.61) and Forced Expiratory Flow (FEF) (r = 0.63) and hydrogen sulfide w.r.t FEV1 (r = 0.54), FVC (r = 0.41) and FEF (r = 0.37). Whereas, weak correlation was found for acetone and alcohol w.r.t FEV1, FVC and PEF. Therefore, the level of ammonia and hydrogen sulfide are useful breath markers for detection of obstructive lung disease. Full article
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Review

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21 pages, 7194 KiB  
Review
A Review of THz Technologies for Rapid Sensing and Detection of Viruses including SARS-CoV-2
by Naznin Akter, Muhammad Mahmudul Hasan and Nezih Pala
Biosensors 2021, 11(10), 349; https://doi.org/10.3390/bios11100349 - 22 Sep 2021
Cited by 21 | Viewed by 5031
Abstract
Virus epidemics such as Ebola virus, Zika virus, MERS-coronavirus, and others have wreaked havoc on humanity in the last decade. In addition, a coronavirus (SARS-CoV-2) pandemic and its continuously evolving mutants have become so deadly that they have forced the entire technical advancement [...] Read more.
Virus epidemics such as Ebola virus, Zika virus, MERS-coronavirus, and others have wreaked havoc on humanity in the last decade. In addition, a coronavirus (SARS-CoV-2) pandemic and its continuously evolving mutants have become so deadly that they have forced the entire technical advancement of healthcare into peril. Traditional ways of detecting these viruses have been successful to some extent, but they are costly, time-consuming, and require specialized human resources. Terahertz-based biosensors have the potential to lead the way for low-cost, non-invasive, and rapid virus detection. This review explores the latest progresses in terahertz technology-based biosensors for the virus, viral particle, and antigen detection, as well as upcoming research directions in the field. Full article
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