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Biosensors
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Biosensors for the Analysis and Detection of Drug, Food and...
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Biosensors for the Analysis and Detection of Drug, Food and Disease Markers

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 16528

Special Issue Editor

Dr. Peng Zuo

E-Mail Website
Guest Editor
Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
Interests: bioanalysis and biosensing; microfluidic and microarray; food safety; environmental pollution detection; clinical diagnosis analysis

Special Issue Information

Dear Colleagues,

Biosensors calls for original research papers, comprehensive reviews, and communications for the present Special Issue, “Biosensors for the Analysis and Detection of Drug, Food and Disease Markers.”

Biosensors, sensors based on biological recognition elements identifying analytes of interest, have been widely researched and developed as tools for application in the medical, environmental, food, and pharmaceutical fields. The rapid development of health-related fields, such as drugs, food, and disease diagnosis, has brought new challenges and opportunities to biosensor development. Novel sensing principles, new recognition elements and sensing materials, different signal conversions, and processing and amplification strategies have been extensively researched and developed. These easy, rapid, integrated, portable, flexible, low-cost, highly sensitive, and highly selective biosensors have numerous existing and prospective applications in these health-related domains. This field is thus rapidly transforming into the most popular and extensively studied discipline. With this Special Issue, we aim to provide an improved understanding of biosensors for the analysis and detection of drugs, food, and disease markers, and to showcase recent development and progress in these areas.

Topics for this Special Issue include, but are not limited to:

  • Novel biological elements, new biosensing materials, and novel sensing principles able to detect analytes in food, drug, and biomarkers.
  • Signal amplification strategies to increase the sensitivity limit of biosensors for highly sensitive and even ultrasensitive detection of trace analytes in food, drug, and biomarkers.
  • Integrated miniaturized transportable devices for use at the POCT.
  • On-line monitoring technologies based on biosensors.

Dr. Peng Zuo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensor
  • microfluidic
  • food safety
  • clinical diagnosis
  • drug discovery
  • drug effect evaluation
  • monitoring
  • pathogen detection
  • chemical contaminants
  • tumor marker

Published Papers (6 papers)

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Research

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14 pages, 2573 KiB  
Article
Staphylococcus aureus Detection in Milk Using a Thickness Shear Mode Acoustic Aptasensor with an Antifouling Probe Linker
by Sandro Spagnolo, Katharina Davoudian, Brian De La Franier, Tibor Hianik and Michael Thompson
Biosensors 2023, 13(6), 614; https://doi.org/10.3390/bios13060614 - 03 Jun 2023
Cited by 2 | Viewed by 1413
Abstract
Contamination of food by pathogens can pose a serious risk to health. Therefore, monitoring for the presence of pathogens is critical to identify and regulate microbiological contamination of food. In this work, an aptasensor based on a thickness shear mode acoustic method (TSM) [...] Read more.
Contamination of food by pathogens can pose a serious risk to health. Therefore, monitoring for the presence of pathogens is critical to identify and regulate microbiological contamination of food. In this work, an aptasensor based on a thickness shear mode acoustic method (TSM) with dissipation monitoring was developed to detect and quantify Staphylococcus aureus directly in whole UHT cow’s milk. The frequency variation and dissipation data demonstrated the correct immobilization of the components. The analysis of viscoelastic properties suggests that DNA aptamers bind to the surface in a non-dense manner, which favors the binding with bacteria. The aptasensor demonstrated high sensitivity and was able to detect S. aureus in milk with a 33 CFU/mL limit of detection. Analysis was successful in milk due to the sensor’s antifouling properties, which is based on 3-dithiothreitol propanoic acid (DTTCOOH) antifouling thiol linker. Compared to bare and modified (dithiothreitol (DTT), 11-mercaptoundecanoic acid (MUA), and 1-undecanethiol (UDT)) quartz crystals, the sensitivity of the sensor’s antifouling in milk improved by about 82–96%. The excellent sensitivity and ability to detect and quantify S. aureus in whole UHT cow’s milk demonstrates that the system is applicable for rapid and efficient analysis of milk safety. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food and Disease Markers)
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15 pages, 2963 KiB  
Article
Sulfonated Starch-Graft-Polyaniline@Graphene Electrically Conductive Nanocomposite: Application for Tyrosinase Immobilization
by Marzieh Aliya, Ehsan Nazarzadeh Zare, Hassan Faridnouri, Matineh Ghomi and Pooyan Makvandi
Biosensors 2022, 12(11), 939; https://doi.org/10.3390/bios12110939 - 28 Oct 2022
Cited by 10 | Viewed by 1291
Abstract
The interaction of tyrosinase with sulfonated starch-graft-polyaniline@graphene (SSt-g-PANI@G) nanocomposite was investigated by electrochemical methods. The activity of the immobilized tyrosinase (Tyase) was proved by the electrochemical detection of three substrates (L-dopa, caffeic acid, and catechol). The SSt-g-PANI@G [...] Read more.
The interaction of tyrosinase with sulfonated starch-graft-polyaniline@graphene (SSt-g-PANI@G) nanocomposite was investigated by electrochemical methods. The activity of the immobilized tyrosinase (Tyase) was proved by the electrochemical detection of three substrates (L-dopa, caffeic acid, and catechol). The SSt-g-PANI@G nanocomposite was characterized by Fourier-transform infrared spectra (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray analysis (EDX), and thermogravimetric analysis (TGA). To immobilize tyrosinase on the surface of the nanocomposite, a simple drop-casting technique was used. The presence of sulfuric acid and hydroxyl groups in SSt, amine groups in PANI, and high surface-to-volume ratio and electrical conductivity of graphene in the prepared nanocomposite led to good enzyme immobilization on the electrode surface. The modified electrode showed a suitable catalytic effect on the electrochemical redox agent, compared with the bare electrode. The peak current responses for three substrates were studied with a calibration curve derived using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). In addition, the fabricated SSt-g-PANI@G/Tyase/GCE showed a more suitable response to catechol, L-dopa, and caffeic acid substrates, respectively. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food and Disease Markers)
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Review

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30 pages, 3310 KiB  
Review
Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects
by Olga I. Guliy, Stella S. Evstigneeva, Vitaly A. Khanadeev and Lev A. Dykman
Biosensors 2023, 13(6), 640; https://doi.org/10.3390/bios13060640 - 09 Jun 2023
Cited by 2 | Viewed by 2049
Abstract
Viruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for [...] Read more.
Viruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for highly sensitive bioanalytical methods to diagnose and monitor socially significant viral diseases has increased in the past few years. This is due, on the one hand, to the increased incidence of viral diseases in general (including the unprecedented spread of a new coronavirus infection, SARS-CoV-2), and, on the other hand, to the need to overcome the limitations of modern biomedical diagnostic methods. Phage display technology antibodies as nano-bio-engineered macromolecules can be used for sensor-based virus detection. This review analyzes the commonly used virus detection methods and approaches and shows the prospects for the use of antibodies prepared by phage display technology as sensing elements for sensor-based virus detection. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food and Disease Markers)
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33 pages, 7933 KiB  
Review
Surface Plasmon Resonance (SPR) Sensor for Cancer Biomarker Detection
by Sreyashi Das, Ram Devireddy and Manas Ranjan Gartia
Biosensors 2023, 13(3), 396; https://doi.org/10.3390/bios13030396 - 17 Mar 2023
Cited by 23 | Viewed by 6317
Abstract
A biomarker is a physiological observable marker that acts as a stand-in and, in the best-case scenario, forecasts a clinically significant outcome. Diagnostic biomarkers are more convenient and cost-effective than directly measuring the ultimate clinical outcome. Cancer is among the most prominent global [...] Read more.
A biomarker is a physiological observable marker that acts as a stand-in and, in the best-case scenario, forecasts a clinically significant outcome. Diagnostic biomarkers are more convenient and cost-effective than directly measuring the ultimate clinical outcome. Cancer is among the most prominent global health problems and a major cause of morbidity and death globally. Therefore, cancer biomarker assays that are trustworthy, consistent, precise, and verified are desperately needed. Biomarker-based tumor detection holds a lot of promise for improving disease knowledge at the molecular scale and early detection and surveillance. In contrast to conventional approaches, surface plasmon resonance (SPR) allows for the quick and less invasive screening of a variety of circulating indicators, such as circulating tumor DNA (ctDNA), microRNA (miRNA), circulating tumor cells (CTCs), lipids, and proteins. With several advantages, the SPR technique is a particularly beneficial choice for the point-of-care identification of biomarkers. As a result, it enables the timely detection of tumor markers, which could be used to track cancer development and suppress the relapse of malignant tumors. This review emphasizes advancements in SPR biosensing technologies for cancer detection. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food and Disease Markers)
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22 pages, 2736 KiB  
Review
Toward the Commercialization of Carbon Nanotube Field Effect Transistor Biosensors
by Zhongyu Li, Mengmeng Xiao, Chuanhong Jin and Zhiyong Zhang
Biosensors 2023, 13(3), 326; https://doi.org/10.3390/bios13030326 - 27 Feb 2023
Cited by 3 | Viewed by 2652
Abstract
The development of biosensors based on field-effect transistors (FETs) using atomically thick carbon nanotubes (CNTs) as a channel material has the potential to revolutionize the related field due to their small size, high sensitivity, label-free detection, and real-time monitoring capabilities. Despite extensive research [...] Read more.
The development of biosensors based on field-effect transistors (FETs) using atomically thick carbon nanotubes (CNTs) as a channel material has the potential to revolutionize the related field due to their small size, high sensitivity, label-free detection, and real-time monitoring capabilities. Despite extensive research efforts to improve the sensitivity, selectivity, and practicality of CNT FET-based biosensors, their commercialization has not yet been achieved due to the non-uniform and unstable device performance, difficulties in their fabrication, the immaturity of sensor packaging processes, and a lack of reliable modification methods. This review article focuses on the practical applications of CNT-based FET biosensors for the detection of ultra-low concentrations of biologically relevant molecules. We discuss the various factors that affect the sensors’ performance in terms of materials, device architecture, and sensor packaging, highlighting the need for a robust commercial process that prioritizes product performance. Additionally, we review recent advances in the application of CNT FET biosensors for the ultra-sensitive detection of various biomarkers. Finally, we examine the key obstacles that currently hinder the large-scale deployment of these biosensors, aiming to identify the challenges that must be addressed for the future industrialization of CNT FET sensors. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food and Disease Markers)
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17 pages, 3719 KiB  
Review
Progress in the Development of Biosensors Based on Peptide–Copper Coordination Interaction
by Gang Liu, Ning Xia, Linxu Tian, Zhifang Sun and Lin Liu
Biosensors 2022, 12(10), 809; https://doi.org/10.3390/bios12100809 - 30 Sep 2022
Cited by 7 | Viewed by 2003
Abstract
Copper ions, as the active centers of natural enzymes, play an important role in many physiological processes. Copper ion-based catalysts which mimic the activity of enzymes have been widely used in the field of industrial catalysis and sensing devices. As an important class [...] Read more.
Copper ions, as the active centers of natural enzymes, play an important role in many physiological processes. Copper ion-based catalysts which mimic the activity of enzymes have been widely used in the field of industrial catalysis and sensing devices. As an important class of small biological molecules, peptides have the advantages of easy synthesis, excellent biocompatibility, low toxicity, and good water solubility. The peptide–copper complexes exhibit the characteristics of low molecular weight, high tenability, and unique catalytic and photophysical properties. Biosensors with peptide–copper complexes as the signal probes have promising application prospects in environmental monitoring and biomedical analysis and diagnosis. In this review, we discussed the design and application of fluorescent, colorimetric and electrochemical biosensors based on the peptide–copper coordination interaction. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food and Disease Markers)
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