Functional Polymers for Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1331

Special Issue Editor

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Guest Editor
Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
Interests: assembly of conductive polymer micro/nano structures; preparation of organic-inorganic nanocomposite materials; electrochemical biosensors; supercapacitors

Special Issue Information

Dear Colleagues,

Over the past decade, a great variety of polymer-based biosensors have been reported in the literature, referring to particular polymers such as polyethyleneimine, polyaniline, PEDOT, or polypyrrole, and derivatives obtained either by electropolymerization or by chemical polymerization, combined with nanomaterials such as CNTs, graphene, or gold nanoparticles. Electropolymerization in deep eutectic solvents (DES) is another interesting approach, and the polymers produced through this method exhibit improved features compared with the same polymers obtained in aqueous solutions.

One of the most important aspects in the development of biosensors is the immobilization platform, which needs to ensure a high stability for the molecular biorecognition compound and to maintain its activity for as long as possible. Entrapment in a polymeric matrix or the employment of a particularly functionalized polymeric film (with amino or carboxyl groups, azide groups for click chemistry, biotine, avidine, or cyclodextrine) are some of the most important immobilization methods for the molecular recognition element in biosensor design. The immobilization of natural receptors (enzyme, antibody, DNA, RNA, peptide, etc.) and biomimetic receptors (ligands such as crown ethers, cryptands, cyclodextrins, or calixarenes) with polymers is one of the most challenging topics.

Nanoparticle–polymer composites are advanced functional materials comprising nanoparticles integrated into a polymer matrix. In addition to the characteristics of polymers, nanocomposites may acquire the outstanding electrical, optical, and magnetic properties of their metal components. Optical nonlinearities and/or infra-low/ultra-high refractive indices make nanocomposites suitable for a number of potential applications, such as ultrathin color filters, UV absorbers, optical sensors, waveguides, optical strain detectors, and thermo-chromic materials. Because of the strong Au and Ag localized surface plasmon resonance (LSPR) bands in the visible spectrum, giving rise to characteristic absorption and strong field confinement and enhancement, some gold nanocomposites are particularly appropriate for sensing applications. LSPR has been extensively exploited for sensing and biosensing, with enormous progress in recent years, both in terms of instrumentation and applications.

The Special Issue aims to highlight not only the most recent advances and challenges, but also the future trends and perspectives in the field of polymer-based biosensors. Reviews and original research papers are all welcome.

Prof. Dr. Xiaomiao Feng
Guest Editor

Manuscript Submission Information

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  • polymer
  • nanocomposite
  • biosensor

Published Papers (1 paper)

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13 pages, 3629 KiB  
Fast Determination of Rutin on a Biosensor Made Using a Layered Double Hydroxide Nanocomposite Modified Electrode
by Yuge Liu, Zhiguo Li, Weizhen Chen and Xiaomiao Feng
Biosensors 2024, 14(1), 18; - 29 Dec 2023
Viewed by 1064
In this study, a nanocomposite of LDH/graphene/polyaniline/gold (LDH/rGO/PANI/Au) was synthesized and characterized. The results of characterization showed that the composite material preserved the layered structure of LDH. The composite was dropped onto the glassy carbon electrode and laccase was then immobilized. Electrochemical tests [...] Read more.
In this study, a nanocomposite of LDH/graphene/polyaniline/gold (LDH/rGO/PANI/Au) was synthesized and characterized. The results of characterization showed that the composite material preserved the layered structure of LDH. The composite was dropped onto the glassy carbon electrode and laccase was then immobilized. Electrochemical tests showed that the composite could accelerate the electron transfer between the enzyme and the electrode. The composite/laccase showed an obvious response to rutin and the optimal detection conditions were discussed. The oxidative peak current of the biosensor constructed using the modified electrode was negatively correlated with rutin in the range of 0.05–4 μg/mL. The detection limit was 0.0017 μg/mL at a signal-to-noise ratio of 3. This biosensor of rutin also possessed high sensitivity, excellent anti-interference ability, and stability. The contents of rutin in tablets, first determined using HPLC, were also detected using the sensor constructed in this research as an application, and the results were acceptable. This research here provides a facile way for the fast detection of rutin in real samples. Full article
(This article belongs to the Special Issue Functional Polymers for Biosensing)
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