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Special Issue "Electrochemiluminescence Biosensors for Imaging or Detection of Biomarkers, Virus, Bacteria, and Metal Ions"

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Dr. Meisheng Wu

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Department of Chemistry, College of Science, Nanjing Agricultural University, Nanjing 210095, China
Interests: electrochemistry; biosensor; electrochemiliminescence; microfluidic chip; amplification strategy

Special Issue Information

Dear Colleagues,

Electrochemiluminescence biosensor is an important analytical device which combines the advantages of highly sensitive electrochemiluminescence techniques and the selectivity of biological recognition events. The designation of portable electrochemiluminescence biosensors for sensitive, selective, and accurate determination of biomarkers, viruses, bacteria, and metal ions has attracted significant attention in recent years. Various amplification strategies, such as nanotechnology, DNA-amplification methods, and enzyme-assisted processes, have been studied and integrated in electrochemiluminescence biosensors to achieve sensitive measurement. Furthermore, by coupling microfabrication technology, these biosensors can realize high-throughput determination through screening the visual electrochemiluminescence signal on the electrode array, making this an effective approach for point-of-care diagnosis.

Therefore, this Special Issue covers the research area of designation of versatile electrochemiluminescence biosensors and their applications in food control, the environmental area, and disease diagnosis.

Dr. Meisheng Wu
Guest Editor

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Keywords

food safety
early disease diagnosis
point of care
electrochemiluminescence
visual assay
high-throughput
electrode array

Published Papers (3 papers)

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Research

Open AccessArticle

Kinetic Determination of Acetylsalicylic Acid Using a CdTe/AgInS₂ Photoluminescence Probe and Different Chemometric Models

Rafael C. Castro

Ricardo N. M. J. Páscoa

M. Lúcia M. F. S. Saraiva

João L. M. Santos

and

David S. M. Ribeiro

Biosensors 2023, 13(4), 437; https://doi.org/10.3390/bios13040437 - 30 Mar 2023

Viewed by 499

Abstract

The combination of multiple quantum dots (QDs) in a multi-emitter nanoprobe can be envisaged as a promising sensing scheme, as it enables obtaining a collective response of individual emitters towards a given analyte and allows for achieving specific analyte-response profiles. The processing of these profiles using adequate chemometric methods empowers a more sensitive, reliable and selective determination of the target analyte. In this work, we developed a kinetic fluorometric method consisting of a dual CdTe/AgInS₂ quantum dots photoluminescence probe for the determination of acetylsalicylic acid (ASA). The fluorometric response was acquired as second-order time-based excitation/emission matrices that were subsequently processed using chemometric methods seeking to assure the second-order advantage. The data obtained in this work are considered second-order data as they have a three-dimensional size, I × J × K (where I represents the samples’ number, J the fluorescence emission wavelength while K represents the time). In order to select the most adequate chemometric method regarding the obtained data structure, different chemometric models were tested, namely unfolded partial least squares (U-PLS), N-way partial least squares (N-PLS), multilayer feed-forward neural networks (MLF-NNs) and radial basis function neural networks (RBF-NNs). Full article

(This article belongs to the Special Issue Electrochemiluminescence Biosensors for Imaging or Detection of Biomarkers, Virus, Bacteria, and Metal Ions)

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Open AccessArticle

Sandwich-Type Electrochemiluminescence Immunosensor Based on CDs@dSiO₂ Nanoparticles as Nanoprobe and Co-Reactant

and

Biosensors 2023, 13(1), 133; https://doi.org/10.3390/bios13010133 - 13 Jan 2023

Cited by 1 | Viewed by 860

Abstract

In general, co-reactants are essential in highly efficient electrochemiluminescence (ECL) systems. Traditional co-reactants are usually toxic, so it is necessary to develop new environmentally friendly co-reactants. In this work, carbon dots (CDs) were assembled with dendritic silica nanospheres (CDs@dSiO₂ NPs) to form a co-reactant of Ru(bpy)₃²⁺. Subsequently, a sandwich immunosensor for detecting human chorionic gonadotropin (HCG) was constructed based on CDs@dSiO₂ NPs as co-reactants, the nanoprobe loaded with the secondary antibody, and Ru(bpy)₃²⁺ as a luminophore. In addition, compared to directly as a signal probe, the luminophore Ru (bpy)₃²⁺ as a part of the electrolyte solution is simpler in this work. The immunosensor has an extremely low limit of detection of 0.00019 mIU/mL. This work describes the synthesis of low-toxic, efficient, and environmentally friendly CDs, which have become ideal co-reactants of Ru(bpy)₃²⁺, and proposes an ECL immunosensor with excellent stability and selectivity, which has great potential in clinical applications. Full article

(This article belongs to the Special Issue Electrochemiluminescence Biosensors for Imaging or Detection of Biomarkers, Virus, Bacteria, and Metal Ions)

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Open AccessArticle

Electrochemiluminescence Aptasensor Based on Gd(OH)₃ Nanocrystalline for Ochratoxin A Detection in Food Samples

and

Biosensors 2022, 12(12), 1141; https://doi.org/10.3390/bios12121141 - 07 Dec 2022

Viewed by 727

Abstract

In the present study, the electrochemiluminescence (ECL) properties of Gd(OH)₃ nanocrystals with K₂S₂O₈ as the cathode coreactant were studied for the first time. Based on the prominent ECL behavior of this material and the excellent specificity of the aptamer technique, an ECL aptasensor for the detection of ochratoxin A (OTA) was formulated successfully. Over an OTA concentration range of 0.01 pg mL⁻¹ to 10 ng mL⁻¹, the change in the ECL signal was highly linear with the OTA concentration, and the limit of detection (LOD) was 0.0027 pg mL⁻¹. Finally, the ECL aptasensor was further used to detect OTA in real samples (grapes and corn) and satisfactory results were obtained, which indicated that the built method is expected to be applied in food detection. Full article

(This article belongs to the Special Issue Electrochemiluminescence Biosensors for Imaging or Detection of Biomarkers, Virus, Bacteria, and Metal Ions)

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Special Issue "Electrochemiluminescence Biosensors for Imaging or Detection of Biomarkers, Virus, Bacteria, and Metal Ions"

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