Special Issue "Synthesis and Portable Biosensing Applications with Functional Nano-Composite Materials"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 1184

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue deals with nanotechnological aspects of devices for the development of selective portable sensor probes with functional nanocomposite materials on portable substrates. Nanocomposites have been developed for a variety of sensor applications, ranging from chemicals to biochemicals, for the safety of environmental and healthcare fields. It will also focus on a particular field of sensor applications of functionalized carbon, nanostructure, nanoscale, and nanocomposite materials as sensor devices by using electrochemical approaches. This Special Issue aims to publish state-of-the-art original articles and comprehensive reviews covering nanocomposite-material-based chemicals and biosensors from the perspectives of their design, fabrication, characterization, analysis, investigation, and/or applications. Although the emphasis is on practical applications, fundamental concepts and practical studies of functional nanocomposite materials are also considered. I hope this selective special topic proves insightful and that the contributions amassed in this collection capture its conventional essence and lead to innovative routes of preparation, improvement, and continuous changes with multidimensional approaches in nano- and biotechnological areas. This collection focuses on cutting-edge nanosciences and biotechnology of functional nanocomposite materials. It is expected that the collection will serve as a guide to the preparation of novel doped or undoped materials with special properties, functions, characterization, and potential applications. It will also pave the path toward promising possibilities for solutions to environmental, biomedical, and healthcare problems. I hope that this issue contributes to facilitating an appealing research atmosphere that provides valuable resources for the next generations.

Prof. Dr. Mohammed Rahman
Guest Editor

Manuscript Submission Information

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  • nanocomposites
  • sensors
  • biosensors
  • electrochemistry
  • portable devices
  • ionic sensors
  • volatiles or liquid sensing
  • water sensors
  • heavy metal ion sensors
  • real-time sensing
  • electrochemiluminescence sensors
  • imaging
  • drug delivery
  • immunosensors
  • porous nanoparticle-based sensors
  • cellulose sensors
  • carbon nanotubes
  • electronic sensors
  • nanosensors
  • polymeric sensors
  • pH sensors
  • enzyme sensors
  • 3D sensors
  • DNA sensors

Published Papers (1 paper)

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24 pages, 4901 KiB  
Magnetic Relaxation Switching Assay Using IFNα-2b-Conjugated Superparamagnetic Nanoparticles for Anti-Interferon Antibody Detection
Biosensors 2023, 13(6), 624; https://doi.org/10.3390/bios13060624 - 05 Jun 2023
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Type I interferons, particularly IFNα-2b, play essential roles in eliciting adaptive and innate immune responses, being implicated in the pathogenesis of various diseases, including cancer, and autoimmune and infectious diseases. Therefore, the development of a highly sensitive platform for analysis of either IFNα-2b [...] Read more.
Type I interferons, particularly IFNα-2b, play essential roles in eliciting adaptive and innate immune responses, being implicated in the pathogenesis of various diseases, including cancer, and autoimmune and infectious diseases. Therefore, the development of a highly sensitive platform for analysis of either IFNα-2b or anti-IFNα-2b antibodies is of high importance to improve the diagnosis of various pathologies associated with the IFNα-2b disbalance. For evaluation of the anti-IFNα-2b antibody level, we have synthesized superparamagnetic iron oxide nanoparticles (SPIONs) coupled with the recombinant human IFNα-2b protein (SPIONs@IFNα-2b). Employing a magnetic relaxation switching assay (MRSw)-based nanosensor, we detected picomolar concentrations (0.36 pg/mL) of anti-INFα-2b antibodies. The high sensitivity of the real-time antibodies’ detection was ensured by the specificity of immune responses and the maintenance of resonance conditions for water spins by choosing a high-frequency filling of short radio-frequency pulses of the generator. The formation of a complex of the SPIONs@IFNα-2b nanoparticles with the anti-INFα-2b antibodies led to a cascade process of the formation of nanoparticle clusters, which was further enhanced by exposure to a strong (7.1 T) homogenous magnetic field. Obtained magnetic conjugates exhibited high negative MR contrast-enhancing properties (as shown by NMR studies) that were also preserved when particles were administered in vivo. Thus, we observed a 1.2-fold decrease of the T2 relaxation time in the liver following administration of magnetic conjugates as compared to the control. In conclusion, the developed MRSw assay based on SPIONs@IFNα-2b nanoparticles represents an alternative immunological probe for the estimation of anti-IFNα-2b antibodies that could be further employed in clinical studies. Full article
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