Special Issue "Applications of DNA-Based Biosensors in Diagnostics"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 284

Special Issue Editors

Department of Mechanics, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200444, China
Interests: biosensor; structure vibration; nanomechanics; DNA-related devices; mechanical property; viscoelasticity
Associate Professor, School of Mechanical Engineering and Rail Transit, Changzhou University, Changzhou 213164, China
Interests: biosensor; multi-field coupling theory and intelligent devices; nanomechanics

Special Issue Information

Dear Colleagues,

This Special Issue concerns the use of DNA-based biosensors as analytical detection devices for diagnostics in different fields, including applications in human health, drug discovery, food analysis, bio-security, environmental monitoring, process industries, and so on. This Special Issue aims to collate original and significant works showing the basic principles, designs, interpretation models, developments, applications of DNA-based biosensors.

DNA is not only one of best known biomacromolecules in human cells and almost all living organisms, but it also constitutes an excellent material endowed with unique properties such as biocompatibility, stability, specificity and programmability. Due to these great advantages, many biosensors with DNA as a probe molecule have been fabricated, representing powerful tools for chemical, biological and medical applications.

The main principle of DNA-based biosensors is illustrated in graphical abstract, endowed as they are with a biological recognition element, transducer, and detector. First, genetic molecules are extracted from diagnostic analytes including diseased or cancerous cells, viruses (such as COVID-19 and HIV), or other biological components. Then, these DNA recognition elements can be integrated with transducers via immobilization, induced by covalent interaction, cross-linking, or adsorption. Finally, the transducers can convert molecular biological signals into measurable signals, such as takes place with the optical, or electrical, or mechanical method, which will be analyzed automatically by computation devices.

Although DNA-based biosensors have played a huge role in many areas, especially in the current global coronavirus outbreak, there are still many open questions on this matter: How to surpass the limitations of the molecular detection and diagnostic devices? How to improve the fabrication reproducibility and detection signal stability? What is the transduction mechanism for DNA detections, especially at nanoscale biomolecular interfaces? What are the new trends in the design of DNA biosensors that make it low cost and more integratable with new functionality? Any relevant contribution to this blooming field is welcome for submission to this Special Issue.

Prof. Dr. Nenghui Zhang
Dr. Zouqing Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA biosensor
  • diagnostic device
  • surface modification
  • biomolecular interaction
  • detection signal
  • virus detection
  • DNA nanotechnology
  • nanomaterial
  • modelling

Published Papers

This special issue is now open for submission.
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