Special Issue "SERS-Based Biosensors: Design and Biomedical Applications"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 216

Special Issue Editors

Dr. Ojodomo J. Achadu
E-Mail Website1 Website2
Guest Editor
School of Health and Life Sciences, and National Horizon Centre (NHC), Teesside University, Middlesbrough TS1 3BA, UK
Interests: nanomaterials (materials) chemistry and engineering; optical spectroscopy; surface-enhanced Raman scattering (SERS)-based diagnostic biosensors design; nanobiosensors design for pathogens (infectious viruses) and neurodegenerative disease diagnostics; Raman microscopy and imaging technique development
Prof. Dr. Islam Meez
E-Mail Website
Guest Editor
School of Health and Life Sciences, and National Horizon Centre (NHC), Teesside University, Middlesbrough TS1 3BA, UK
Interests: optical spectroscopy; development and application of cavity-enhanced spectroscopy; development and application of UV-Visible hyperspectral imaging; development and application of Raman spectroscopy to biomedical sciences; application of FTIR spectroscopy; design and fabrication of optical instruments

Special Issue Information

Dear Colleagues,

In recent years, surface-enhanced Raman scattering (SERS) spectroscopy has gained recognition as a powerful tool for chemical analysis and for determining structural information about molecular systems in a wide range of fields. The emerging applications in the biomedical sciences include the chemical characterisation of biomarkers, diagnostic immunoassays for disease detection and non-invasive cellular and tissue imaging. The SERS effect and mechanism is based on the strong amplification of the Raman signals of target molecules adsorbed and/or in proximity with Au or Ag metallic nanostructures and plasmonic quantum dots, which are commonly utilised in colloidal form or supported on solid substrates. The degree of SERS amplification is greatly dependent on the substrates employed for qualitative analysis and quantitative detection. Therefore, the development of SERS technologies with high sensitivity, reproducible results, and stability has become a hot topic in recent years, particularly as a clinical tool in the biomedical fields.

Interestingly, innovations in Raman instrumentation have played a role in the rapid development of SERS and related concepts. These technological advances include confocal Raman microscopy (CRM), spatially offset Raman scattering (SORS), tip-enhanced Raman scattering spectroscopy (TERS), and surface-enhanced Raman chemical imaging (SER-CI).

For this Special Issue, we welcome original research papers as well as reviews on current developments in the design of high-sensitivity and reproducible biomedical diagnostic systems with SERS, TERS, CRM, and/or SORS technologies. This includes the design of state-of-the art biosensors for disease biomarkers, characterisation of biomolecules, biological analysis, and medical diagnostics. Theoretical research on the interaction and spatial distribution of adsorbate biomaterials on metal surfaces and substrates is also encouraged. The design and development of lab-on-a-chip devices, wearable and plug-and-play biosensors, and portable/handheld SERS-based platforms for point-of-care applications is of special interest. Reviews should provide an in-depth examination of the most recent research in a specific context or discuss the existing and future issues related with SERS and Raman imaging in the biomedical field.

Dr. Ojodomo J. Achadu
Prof. Dr. Islam Meez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • SERS
  • Raman imaging
  • biosensing
  • plasmonic nanostructures
  • disease diagnostics
  • biomarker detection
  • biomolecules characterisation

Published Papers

This special issue is now open for submission.
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