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Biosensors
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Biosensors and Bioelectronics Based on Molecular Logic Computing
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Biosensors and Bioelectronics Based on Molecular Logic Computing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3404

Special Issue Editor

Dr. Daoqing Fan

E-Mail Website
Guest Editor
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Interests: molecular logic computing; DNA nanotechnology; smart biosensing; nanozyme catalysis; pharmaceutical analysis

Special Issue Information

Dear Colleagues,

As a promising substitute for semiconductor computers, capable of performing Boolean logic at a molecular level, molecular logic computing has made prosperous developments; DNAs, enzymes, proteins, and other elements can be used as building blocks, and optical, electrochemical signals are taken as binary outputs. In recent decades, apart from traditional computing functions, great efforts have been made to explore those areas where “silicon logic circuits cannot go”, such as smart biosensing, disease diagnostics, pharmaceutical analysis, food quality control, and accurate biotherapy.

This Special Issue, "Biosensors and Bioelectronics Based on Molecular Logic Computing", aims to highlight recent advances in molecular computing and logic-programmed smart biosensing applications. We welcome both original works and reviews that are related to biomolecular computing and logical/point-of-care (POC) sensors for detecting various targets (tumor biomarkers, nucleic acids, proteins, drugs, antibiotics, etc.). We hope that this Special Issue will not only inform experts and newcomers in this research area, but that it will also be a reference for future advancements of this field.

Best regards,

Dr. Daoqing Fan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular logic devices
  • DNA computing
  • DNA nanotechnology
  • disease biomarkers
  • nucleic acids
  • nanozymes
  • electrochemical sensors
  • drug analysis
  • point-of-care test (POCT)

Published Papers (2 papers)

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Research

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12 pages, 2599 KiB  
Article
Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection
by Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang and Daoqing Fan
Biosensors 2023, 13(4), 489; https://doi.org/10.3390/bios13040489 - 19 Apr 2023
Cited by 5 | Viewed by 1218
Abstract
The effective and accurate detection of the anticancer drug coralyne (COR) is highly significant for drug quality control, medication safety and good health. Although various COR sensors have been reported in recent years, previous ones can only exhibit single-signal output (turn ON or [...] Read more.
The effective and accurate detection of the anticancer drug coralyne (COR) is highly significant for drug quality control, medication safety and good health. Although various COR sensors have been reported in recent years, previous ones can only exhibit single-signal output (turn ON or turn OFF) with poor reliability and anti-interference ability. Therefore, exploring novel platform with dual-signal response for COR detection is urgently needed. Herein, we reported the first ratiometric fluorescent platform for highly sensitive and selective COR detection by integrating G-quadruplex (G4) and Pyrene (Py) as signal probes and harnessing A-COR-A interaction. In the absence of COR, the platform shows a low fluorescence signal of PPIX (F642) and a high one of Py monomer (F383). With the addition of COR, two delicately designed poly-A ssDNAs will hybridize with each other via A-COR-A coordination to form complete G4, yielding the increased fluorescence signal of PPIX and the decreased one of Py due to the formation of Py excimer. Based on the above mechanism, we constructed a simple and efficient sensor that could realize the ratiometric fluorescent detection of COR with high sensitivity and selectivity. A linear relationship between F642/F383 and COR’s concentration is obtained in the range from 1 nM to 8 μM. And the limit of detection of COR could reach to as low as 0.63 nM without any amplification, which is much lower than that of most COR sensors reported so far. Notably, the logical analysis of COR can be carried out under the control of a “YES-NOT” contrary logic pair, enabling the smart dual-channel response with an adequate S/N ratio and improved reliability and anti-interference ability. Moreover, this system also presents satisfactory performance in fetal bovine serum (FBS) samples. Full article
(This article belongs to the Special Issue Biosensors and Bioelectronics Based on Molecular Logic Computing)
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Review

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30 pages, 8961 KiB  
Review
Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application
by Nataliia Dudchenko, Shweta Pawar, Ilana Perelshtein and Dror Fixler
Biosensors 2023, 13(3), 304; https://doi.org/10.3390/bios13030304 - 21 Feb 2023
Cited by 1 | Viewed by 1779
Abstract
In the last few decades, point-of-care (POC) sensors have become increasingly important in the detection of various targets for the early diagnostics and treatment of diseases. Diverse nanomaterials are used as building blocks for the development of smart biosensors and magnetite nanoparticles (MNPs) [...] Read more.
In the last few decades, point-of-care (POC) sensors have become increasingly important in the detection of various targets for the early diagnostics and treatment of diseases. Diverse nanomaterials are used as building blocks for the development of smart biosensors and magnetite nanoparticles (MNPs) are among them. The intrinsic properties of MNPs, such as their large surface area, chemical stability, ease of functionalization, high saturation magnetization, and more, mean they have great potential for use in biosensors. Moreover, the unique characteristics of MNPs, such as their response to external magnetic fields, allow them to be easily manipulated (concentrated and redispersed) in fluidic media. As they are functionalized with biomolecules, MNPs bear high sensitivity and selectivity towards the detection of target biomolecules, which means they are advantageous in biosensor development and lead to a more sensitive, rapid, and accurate identification and quantification of target analytes. Due to the abovementioned properties of functionalized MNPs and their unique magnetic characteristics, they could be employed in the creation of new POC devices, molecular logic gates, and new biomolecular-based biocomputing interfaces, which would build on new ideas and principles. The current review outlines the synthesis, surface coverage, and functionalization of MNPs, as well as recent advancements in magnetite-based biosensors for POC diagnostics and some perspectives in molecular logic, and it also contains some of our own results regarding the topic, which include synthetic MNPs, their application for sample preparation, and the design of fluorescent-based molecular logic gates. Full article
(This article belongs to the Special Issue Biosensors and Bioelectronics Based on Molecular Logic Computing)
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