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Special Issue "Electrochemical Biosensors for Disease Detection"

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A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 20 March 2024 | Viewed by 12119

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Special Issue Editors

Prof. Dr. Li Wu

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Guest Editor

School of Public Health, Nantong University, Nantong 226019, China
Interests: biomarkers; accurate diagnosis; biosensors, micro-fluidic chip; POCT; electrochemistry

Prof. Dr. Lingyan Feng

E-Mail Website1 Website2
Guest Editor

Materials Genome Institute, Shanghai University, Shanghai 200444, China
Interests: electrochemical biosensors, high-throughput material preparation, biofunctional materials and their optical/electrochemical applications; molecular recognition and biosensor design; high-throughput catalytic equipment research and development

Dr. Jinxia Liu

E-Mail Website
Guest Editor

School of Public Health, Nantong University, Nantong 226019, China
Interests: electrochemistry; electrochemiluminescence; biosensors; immunoassay; nanomaterials

Special Issue Information

Dear Colleagues,

Detection of diseases at the early stage is important both for patient health and the reduction of treatment costs. Therefore, it is important to have highly sensitive and diverse techniques that can be effective in the early stages of diseases. Miniaturized, economic, and practical devices that have the capacity to replace time-consuming laboratory analyses are urgently needed for diagnostic processes. Electrochemical biosensors play a significant role in point-of-care testing (POCT) diagnostics because they are rapid, real-time, cost-effective, able for miniaturization, and intelligent. Hence, this Special Issue "Electrochemical Biosensors for Disease Detection" focuses on the recent advances of electrochemical biosensors in the sensitivity amplification strategies, point-of-care diagnostics, nanotechnology, and their applications in the detection and discovery of disease biomarkers (DNA, RNA, antigen, antibody, small molecules, and, etc.). We invite submissions of research that help to advance the field of electrochemical biosensors and their application for high-throughput analysis of disease biomarkers.

Prof. Dr. Li Wu
Prof. Dr. Lingyan Feng
Dr. Jinxia Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

electrochemical biosensors
biomarkers
signal amplification
POCT
DNA
RNA
antigen
antibody
small molecules

Published Papers (7 papers)

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Research

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Open AccessArticle

Mn₃O₄/NiO Nanoparticles Decorated on Carbon Nanofibers as an Enzyme-Free Electrochemical Sensor for Glucose Detection

and

Biosensors 2023, 13(2), 264; https://doi.org/10.3390/bios13020264 - 13 Feb 2023

Cited by 4 | Viewed by 1242

Abstract

Transition metal oxides have garnered a lot of attention in the field of electrocatalysis along with their unique crystal structure and excellent catalytic properties. In this study, carbon nanofibers (CNFs) decorated with Mn₃O₄/NiO nanoparticles were made using electrospinning and calcination. The conductive network constructed by CNFs not only facilitates electron transport, but also provides landing sites for nanoparticles, thus reducing nanoparticle aggregation and exposing more active sites. Additionally, the synergistic interaction between Mn₃O₄ and NiO improved electrocatalytic capacity for glucose oxidation. The Mn₃O₄/NiO/CNFs modified glassy carbon electrode shows satisfactory results in terms of linear range and anti-interference capability for glucose detection, suggesting that the constructed enzyme-free sensor has a promising application in clinical diagnosis. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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Open AccessArticle

A Dual-Function Wearable Electrochemical Sensor for Uric Acid and Glucose Sensing in Sweat

and

Biosensors 2023, 13(1), 105; https://doi.org/10.3390/bios13010105 - 06 Jan 2023

Cited by 7 | Viewed by 2488

Abstract

Simultaneous detection of uric acid and glucose using a non-invasive approach can be a promising strategy for related diseases, e.g., diabetes, gout, kidney disease, and cardiovascular disease. In this study, we have proposed a dual-function wearable electrochemical sensor for uric acid and glucose detection in sweat. The sensor with a four-electrode system was prepared by printing the ink on a common rubber glove. CV and chronoamperometry were used to characterize the prepared sensor’s electrochemical sensing performance. The sensors exhibited the linear range from 0 to 1.6 mM and 0 to 3.7 mM towards uric acid and glucose electrochemical sensing in phosphate-buffered solution, with the corresponding limit of detection of 3.58 μM and 9.10 μM obtained, respectively. Moreover, the sensors had shown their feasibility of real sample sensing in sweat. The linear detection range for uric acid (0 to 40 μM) and glucose (0 to 1.6 mM) in the sweat can well cover their concentration range in physiological conditions. The prepared dual-function wearable electrochemical sensor features easy preparation, fast detection, high sensitivity, high selectivity, and the practical application potential in uric acid and glucose sensing. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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Open AccessArticle

Ultrasensitive Electrochemiluminescence Immunoassay Based on Signal Amplification of 0D Au—2D WS₂ Nano-Hybrid Materials

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Biosensors 2023, 13(1), 58; https://doi.org/10.3390/bios13010058 - 30 Dec 2022

Viewed by 1422

Abstract

In this study, we proposed a novel Ru(bpy)₃²⁺-Au-WS₂ nanocomposite (Ru-Au-WS₂ NCs) nano-hybrid electrochemiluminescence (ECL) probe for the highly sensitive detection of carcinoembryonic antigen (CEA). This system utilizes Au nanoparticles (Au NPs) as a bridge to graft the high-performance of a Ru(bpy)₃²⁺ ECL emitter and WS₂ nanosheet with excellent electrochemical performance into an ECL platform, which shows outstanding anodic ECL performance and biosensing platform due to the synergetic effect and biocompatibility of Au NPs and WS₂ nanosheet. Because the ECL intensity of Ru(bpy)₃²⁺ is sensitively affected by the antibody-antigen insulator, a preferable linear dependence was obtained in the concentration range of CEA from 1 pg·mL⁻¹ to 350 ng·mL⁻¹ with high selectivity (LOD of 0.3 pg·mL⁻¹, S/N = 3). Moreover, the ECL platform had good reproducibility and stability and exhibited excellent anti-interference performance in the detection process of CEA. We believe that the platform we have developed can expand the opportunities for the detection of additional high specificity-related antibodies/antigens and demonstrate broad prospects for disease diagnosis and biochemical research. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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Open AccessArticle

Target Recognition– and HCR Amplification–Induced In Situ Electrochemical Signal Probe Synthesis Strategy for Trace ctDNA Analysis

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Biosensors 2022, 12(11), 989; https://doi.org/10.3390/bios12110989 - 08 Nov 2022

Cited by 1 | Viewed by 1063

Abstract

An electrochemical-DNA (E-DNA) sensor was constructed by using DNA metallization to produce an electrochemical signal reporter in situ and hybridization chain reaction (HCR) as signal amplification strategy. The cyclic voltammetry (CV) technique was used to characterize the electrochemical solid-state Ag/AgCl process. Moreover, the enzyme cleavage technique was introduced to reduce background signals and further improve recognition accuracy. On the basis of these techniques, the as-prepared E-DNA sensor exhibited superior sensing performance for trace ctDNA analysis with a detection range of 0.5 fM to 10 pM and a detection limit of 7 aM. The proposed E-DNA sensor also displayed excellent selectivity, satisfied repeatability and stability, and had good recovery, all of which supports its potential applications for future clinical sample analysis. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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Review

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Open AccessReview

Newly Developed Electrochemiluminescence Based on Bipolar Electrochemistry for Multiplex Biosensing Applications: A Consolidated Review

Christopher Mwanza

and

Shou-Nian Ding

Biosensors 2023, 13(6), 666; https://doi.org/10.3390/bios13060666 - 19 Jun 2023

Viewed by 1412

Abstract

Recently, there has been an upsurge in the extent to which electrochemiluminescence (ECL) working in synergy with bipolar electrochemistry (BPE) is being applied in simple biosensing devices, especially in a clinical setup. The key objective of this particular write-up is to present a consolidated review of ECL-BPE, providing a three-dimensional perspective incorporating its strengths, weaknesses, limitations, and potential applications as a biosensing technique. The review encapsulates critical insights into the latest and novel developments in the field of ECL-BPE, including innovative electrode designs and newly developed, novel luminophores and co-reactants employed in ECL-BPE systems, along with challenges, such as optimization of the interelectrode distance, electrode miniaturization and electrode surface modification for enhancing sensitivity and selectivity. Moreover, this consolidated review will provide an overview of the latest, novel applications and advances made in this field with a bias toward multiplex biosensing based on the past five years of research. The studies reviewed herein, indicate that the technology is rapidly advancing at an outstanding purse and has an immense potential to revolutionize the general field of biosensing. This perspective aims to stimulate innovative ideas and inspire researchers alike to incorporate some elements of ECL-BPE into their studies, thereby steering this field into previously unexplored domains that may lead to unexpected, interesting discoveries. For instance, the application of ECL-BPE in other challenging and complex sample matrices such as hair for bioanalytical purposes is currently an unexplored area. Of great significance, a substantial fraction of the content in this review article is based on content from research articles published between the years 2018 and 2023. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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Open AccessReview

Recent Development of Neural Microelectrodes with Dual-Mode Detection

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Biosensors 2023, 13(1), 59; https://doi.org/10.3390/bios13010059 - 30 Dec 2022

Cited by 1 | Viewed by 2376

Abstract

Neurons communicate through complex chemical and electrophysiological signal patterns to develop a tight information network. A physiological or pathological event cannot be explained by signal communication mode. Therefore, dual-mode electrodes can simultaneously monitor the chemical and electrophysiological signals in the brain. They have been invented as an essential tool for brain science research and brain-computer interface (BCI) to obtain more important information and capture the characteristics of the neural network. Electrochemical sensors are the most popular methods for monitoring neurochemical levels in vivo. They are combined with neural microelectrodes to record neural electrical activity. They simultaneously detect the neurochemical and electrical activity of neurons in vivo using high spatial and temporal resolutions. This paper systematically reviews the latest development of neural microelectrodes depending on electrode materials for simultaneous in vivo electrochemical sensing and electrophysiological signal recording. This includes carbon-based microelectrodes, silicon-based microelectrode arrays (MEAs), and ceramic-based MEAs, focusing on the latest progress since 2018. In addition, the structure and interface design of various types of neural microelectrodes have been comprehensively described and compared. This could be the key to simultaneously detecting electrochemical and electrophysiological signals. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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Open AccessReview

Electrochemical Biosensors Based on Carbon Nanomaterials for Diagnosis of Human Respiratory Diseases

Chunmei Li

Bo Che

and

Linhong Deng

Biosensors 2023, 13(1), 12; https://doi.org/10.3390/bios13010012 - 22 Dec 2022

Cited by 2 | Viewed by 1196

Abstract

In recent years, respiratory diseases have increasingly become a global concern, largely due to the outbreak of Coronavirus Disease 2019 (COVID-19). This inevitably causes great attention to be given to the development of highly efficient and minimal or non-invasive methods for the diagnosis of respiratory diseases. And electrochemical biosensors based on carbon nanomaterials show great potential in fulfilling the requirement, not only because of the superior performance of electrochemical analysis, but also given the excellent properties of the carbon nanomaterials. In this paper, we review the most recent advances in research, development and applications of electrochemical biosensors based on the use of carbon nanomaterials for diagnosis of human respiratory diseases in the last 10 years. We first briefly introduce the characteristics of several common human respiratory diseases, including influenza, COVID-19, pulmonary fibrosis, tuberculosis and lung cancer. Then, we describe the working principles and fabrication of various electrochemical biosensors based on carbon nanomaterials used for diagnosis of these respiratory diseases. Finally, we summarize the advantages, challenges, and future perspectives for the currently available electrochemical biosensors based on carbon nanomaterials for detecting human respiratory diseases. Full article

(This article belongs to the Special Issue Electrochemical Biosensors for Disease Detection)

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