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Biosensors
Special Issues
Biospectroscopy-Based Biosensing Platforms
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Biospectroscopy-Based Biosensing Platforms

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3374

Special Issue Editors

Prof. Dr. Pedro Bertemes-Filho

E-Mail Website
Guest Editor
Department of Electrical Engineering, Santa Catarina State University, Joinville 89219710, Brazil
Interests: electrical impedance spectroscopy; bioimpedance, biosensors; medical sensors; bioinstrumentation; IoT sensors; wearable sensors; biosensing devices
Dr. Paul Annus

E-Mail Website
Guest Editor
Thomas Johann Seebeck Department of Electronics, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn, Estonia
Interests: electronics; biompedance; signal processing; embedded systems
Dr. Cesar Antonio Gonzalez Diaz

E-Mail Website
Guest Editor
Instituto Politécnico Nacional-Escuela Superior de Medicina, CDMX, Mexico 11340, Mexico
Interests: bioimpedance; biosensors; spectroscopy

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue is electrical bioimpedance analysis (EBIA) which uses biosensors as miniaturized and disposable detection devices for specific chemical (or sets of chemicals), biomolecules, adulterants, and microorganisms analysis in different fields concerning health point-of-care, food quality, food safety, and pollution. Therefore, this Special Issue aims to gather original articles and reviews showing research advances, fabrication, innovative applications, new challenges, and future perspectives of BIA-based (Bio)sensors in significant areas such as biomedical engineering, health, IoT, agri-food, and environmental.

Several questions are asked to the audience: what are the new trends in the design of BIA-based biosensor (BIA-bios) devices? Which are the key components? Where are the critical points in the fabrication of these devices? What kinds of chemical functionalization are practical for the fabrication of BIA-bios? Is the BIA method sensitive enough to detect material impurities in an analytical response? Can types of electrode geometry/material play a crucial role during biosensing? What is it that society demands? What can we sayabout the upcoming papers on this topic? You are invited to participate in this Special Issue.

Prof. Dr. Pedro Bertemes-Filho
Dr. Paul Annus
Dr. Cesar Antonio Gonzalez Diaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical engineering
  • electrical impedance spectroscopy
  • bioimpedance
  • biosensing plataforms
  • non-invasive devices
  • bioinstrumentation
  • wearable medical sensors
  • IoT sensors
  • artificial inteligent sensors
  • point-of-care

Published Papers (2 papers)

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Research

16 pages, 8433 KiB  
Article
An Approach to Using Electrical Impedance Myography Signal Sensors to Assess Morphofunctional Changes in Tissue during Muscle Contraction
by Vladislava Kapravchuk, Andrey Briko, Alexander Kobelev, Ahmad Hammoud and Sergey Shchukin
Biosensors 2024, 14(2), 76; https://doi.org/10.3390/bios14020076 - 31 Jan 2024
Viewed by 1056
Abstract
This present work is aimed at conducting fundamental and exploratory studies of the mechanisms of electrical impedance signal formation. This paper also considers morphofunctional changes in forearm tissues during the performance of basic hand actions. For this purpose, the existing research benches were [...] Read more.
This present work is aimed at conducting fundamental and exploratory studies of the mechanisms of electrical impedance signal formation. This paper also considers morphofunctional changes in forearm tissues during the performance of basic hand actions. For this purpose, the existing research benches were modernized to conduct experiments of mapping forearm muscle activity by electrode systems on the basis of complexing the electrical impedance signals and electromyography signals and recording electrode systems’ pressing force using force transducers. Studies were carried out with the involvement of healthy volunteers in the implementation of vertical movement of the electrode system and ultrasound transducer when the subject’s upper limb was positioned in the bed of the stand while performing basic hand actions in order to identify the relationship between the morphofunctional activity of the upper limb muscles and the recorded parameters of the electro-impedance myography signal. On the basis of the results of the studies, including complex measurements of neuromuscular activity on healthy volunteers such as the signals of electro-impedance myography and pressing force, analyses of the morphofunctional changes in tissues during action performance on the basis of ultrasound and MRI studies and the factors influencing the recorded signals of electro-impedance myography are described. The results are of fundamental importance and will enable reproducible electro-impedance myography signals, which, in turn, allow improved anthropomorphic control. Full article
(This article belongs to the Special Issue Biospectroscopy-Based Biosensing Platforms)
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21 pages, 11472 KiB  
Article
Surface Functionalization and Escherichia coli Detection Using Surface-Enhanced Raman Spectroscopy Driven by Functional Organic Polymer/Gold Nanofilm-Based Microfluidic Chip
by Hugo Cortes-Cano, Lilian Iraís Olvera, Emilia M. Méndez-Aguilar, Beatriz Liliana España-Sánchez, Luis Gerardo Arriaga, Goldie Oza and José Herrera-Celis
Biosensors 2023, 13(12), 994; https://doi.org/10.3390/bios13120994 - 21 Nov 2023
Cited by 1 | Viewed by 1471
Abstract
In this work, a microfluidic prototype based on polymeric materials was developed to monitor surface processes using surface-enhanced Raman spectroscopy (SERS), keeping the reagents free of environmental contamination. The prototype was fabricated on poly(methyl methacrylic acid) (PMMA). A micrometric membrane of a functional [...] Read more.
In this work, a microfluidic prototype based on polymeric materials was developed to monitor surface processes using surface-enhanced Raman spectroscopy (SERS), keeping the reagents free of environmental contamination. The prototype was fabricated on poly(methyl methacrylic acid) (PMMA). A micrometric membrane of a functional organic polymer (FOP) based on p-terphenyl and bromopyruvic acid monomers was formed on the PMMA surface to promote the formation of metal nanoclusters. Au nanosized film was deposited on the FOP membrane to give rise to the SERS effect. A microchannel was formed on another piece of PMMA using micromachining. A representative 3D model of the prototype layer arrangement was built and simulated in COMSOL Multiphysics® to approximate the electric field distribution and calculate the power enhancement factor as the Au film changes over time. The fabrication process was characterized using UV–visible and Raman spectroscopies and XPS. The prototype was tested using a Raman microscope and liquid solutions of cysteamine and Escherichia coli (E. coli). The simulation results demonstrated that the morphological characteristics of the Au layer give rise to the SERS effect, and the power enhancement factor reaches values as high as 8.8 × 105 on the FOP surface. The characterization results showed the formation of the FOP and the Au film on PMMA and the surface functionalization with amine groups. The Raman spectra of the prototype showed temporal evolution as different compounds were deposited on the upper wall of the microchannel. Characteristic peaks associated with these compounds were detected with continuous monitoring over time. This prototype offers many benefits for applications like monitoring biological processes. Some advantages include timely surface evaluation while avoiding environmental harm, decreased use of reagents and samples, minimal interference with the process by measuring, and detecting microorganisms in just 1 h, as demonstrated with the E. coli sample. Full article
(This article belongs to the Special Issue Biospectroscopy-Based Biosensing Platforms)
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