Recent Trends in Paper-Based Microfluidic Devices

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 11868

Special Issue Editors

Jamia Hamdard, New Delhi, India
Interests: biosensors; sensors; paper based microfluidic; detection of various pathogens and drugs
Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via Salaria Km 29.3, Monterotondo, 00015 Rome, Italy
Interests: electrochemistry; environmental analytical chemistry; biosensors; sensors and sensing; continuous flow monitoring; immobilization techniques; enzyme inhibitors; lab on a chip; nanostructured electrodes; screen-printed electrodes
Special Issues, Collections and Topics in MDPI journals
Department of Bioengineering, Faculty of Engineering, Ege University, 35100 Izmir, Turkey
Interests: biosensors; sensors; paper based microfluidic; detection of various pathogens and drugs

Special Issue Information

Dear Colleagues,

Paper-based microfluidic devices offers many advantageous features, as they are affordable, accurate, and sensitive. Paper-based devices are much better than bulky three-electrode setups, as they reduce the reagent/analyte volume, decrease the time of detection, are affordable, and are able to be mass produced. Paper-based microfluidic devices are fabricated by patterning paper with hydrophobic barriers to define hydrophilic channels and zones. Paper-based devices are best-suited for the development of point-of-care devices. Paper-based devices are being developed to meet the need for  affordable, specific, sensitive, robust, economical, and easy-to-operate devices. These devices reduce the burden on the public health sector by offering diagnoses of communicable and non-communicable diseases. Paper-based devices are not restricted to the public health sector, but have broad applications in quality control, agriculture, and environmental health as well as safety. Nowadays, multiplexed-based detection systems are being extensively researched for the detection of various analytes on a single platform. Paper-based devices have the capabilities of detection in complex matrices and with no interference. Long shelf lives and no specific storage interventions make them well-suited for resource-limited settings and developing countries.

Dr. Narang Jagriti
Prof. Dr. Roberto Pilloton
Dr. Emine Guler Celik
Guest Editors

Manuscript Submission Information

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Keywords

  • paper-based microfluidic
  • origami-paper-based device
  • colorimetric biosensors
  • detection of various pathogens and drugs

Published Papers (3 papers)

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Research

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9 pages, 1777 KiB  
Communication
Electrochemical Aptasensor Developed Using Two-Electrode Setup and Three-Electrode Setup: Comprising Their Current Range in Context of Dengue Virus Determination
by Mohd. Rahil Hasan, Pradakshina Sharma, Shifa Shaikh, Saumitra Singh, Roberto Pilloton and Jagriti Narang
Biosensors 2023, 13(1), 1; https://doi.org/10.3390/bios13010001 - 20 Dec 2022
Cited by 11 | Viewed by 3015
Abstract
We present, for the very first time, the fabrication and electrochemical characterization of a paper-based experimental platform for dengue virus analysis. The paper-based device incorporates a screen-printing technology with the help of black carbon conductive ink. The paper-based device utilizes two styles of [...] Read more.
We present, for the very first time, the fabrication and electrochemical characterization of a paper-based experimental platform for dengue virus analysis. The paper-based device incorporates a screen-printing technology with the help of black carbon conductive ink. The paper-based device utilizes two styles of electrode setups, i.e., the two-electrode system and three-electrode system, and both setups effectively detected the dengue virus with an LOD of 0.1 µg/mL; however, these paper electrodes exhibit various current ranges, and the created sensor was encompassed and compared in this research based on current response. It is observed that the three-electrode system has a substantially higher current range, ranging from 55.53 µA to 322.21 µA, as compared to the two-electrode system, which has a current range of 0.85 µA to 4.54 µA. According to this study, the three-electrode system displayed a good range of current amplification that is roughly 50 times higher than the two-electrode system, which had a weak current response. As a result, the three-electrode method has emerged as a viable option for the very sensitive detection of the dengue virus, as well as for the diagnosis of other diseases. Full article
(This article belongs to the Special Issue Recent Trends in Paper-Based Microfluidic Devices)
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Review

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33 pages, 5539 KiB  
Review
Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics
by Bilge Asci Erkocyigit, Ozge Ozufuklar, Aysenur Yardim, Emine Guler Celik and Suna Timur
Biosensors 2023, 13(3), 387; https://doi.org/10.3390/bios13030387 - 15 Mar 2023
Cited by 14 | Viewed by 4683
Abstract
Microfluidics is very crucial in lab-on-a-chip systems for carrying out operations in a large-scale laboratory environment on a single chip. Microfluidic systems are miniaturized devices in which the fluid behavior and control can be manipulated on a small platform, with surface forces on [...] Read more.
Microfluidics is very crucial in lab-on-a-chip systems for carrying out operations in a large-scale laboratory environment on a single chip. Microfluidic systems are miniaturized devices in which the fluid behavior and control can be manipulated on a small platform, with surface forces on the platform being greater than volumetric forces depending on the test method used. In recent years, paper-based microfluidic analytical devices (μPADs) have been developed to be used in point-of-care (POC) technologies. μPADs have numerous advantages, including ease of use, low cost, capillary action liquid transfer without the need for power, the ability to store reagents in active form in the fiber network, and the capability to perform multiple tests using various measurement techniques. These benefits are critical in the advancement of paper-based microfluidics in the fields of disease diagnosis, drug application, and environment and food safety. Cancer is one of the most critical diseases for early detection all around the world. Detecting cancer-specific biomarkers provides significant data for both early diagnosis and controlling the disease progression. μPADs for cancer biomarker detection hold great promise for improving cure rates, quality of life, and minimizing treatment costs. Although various types of bioanalytical platforms are available for the detection of cancer biomarkers, there are limited studies and critical reviews on paper-based microfluidic platforms in the literature. Hence, this article aims to draw attention to these gaps in the literature as well as the features that future platforms should have. Full article
(This article belongs to the Special Issue Recent Trends in Paper-Based Microfluidic Devices)
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20 pages, 1787 KiB  
Review
Microfluidics as a Ray of Hope for Microplastic Pollution
by Emre Ece, Nedim Hacıosmanoğlu and Fatih Inci
Biosensors 2023, 13(3), 332; https://doi.org/10.3390/bios13030332 - 28 Feb 2023
Cited by 4 | Viewed by 3646
Abstract
Microplastic (MP) pollution is rising at an alarming rate, imposing overwhelming problems for the ecosystem. The impact of MPs on life and environmental cycles has already reached a point of no return; yet global awareness of this issue and regulations regarding MP exposure [...] Read more.
Microplastic (MP) pollution is rising at an alarming rate, imposing overwhelming problems for the ecosystem. The impact of MPs on life and environmental cycles has already reached a point of no return; yet global awareness of this issue and regulations regarding MP exposure could change this situation in favor of human health. Detection and separation methods for different MPs need to be deployed to achieve the goal of reversing the effect of MPs. Microfluidics is a well-established technology that enables to manipulate samples in microliter volumes in an unprecedented manner. Owing to its low cost, ease of operation, and high efficiency, microfluidics holds immense potential to tackle unmet challenges in MP. In this review, conventional MP detection and separation technologies are comprehensively reviewed, along with state-of-the-art examples of microfluidic platforms. In addition, we herein denote an insight into future directions for microfluidics and how this technology would provide a more efficient solution to potentially eradicate MP pollution. Full article
(This article belongs to the Special Issue Recent Trends in Paper-Based Microfluidic Devices)
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