Virus Encoded Tumoricidal Proteins
Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 310
Interests: apoptin; apoptosis; prognostic biomarkers; combination therapy; head and neck cancer; tumour hypoxia
Special Issues, Collections and Topics in MDPI journals
Viruses are known to induce massive changes in their target host cells during infection. Many seminal findings in cancer biology have emerged from the study of virology. The discovery of the Src oncogene and the Rb and p53 tumour suppressors are notable examples. In addition to furthering our understanding of tumorigenesis, viruses are also providing insights into how tumour cells can be selectively targeted for destruction. Several viruses have been demonstrated to encode proteins that can inhibit cell cycle progression or induce cell death selectively in cancer cells. In particular, proteins encoded by single-stranded DNA viruses including Circovirus, Anellovirus and Parvovirus have each been shown to express proteins with tumouricidal properties. These families of viruses have a natural tropism for dividing cells, which may in part explain their ability to target tumour cells. More complex viruses including Adenovirus, Herpesvirus and Poxviruses have also been shown to express proteins that elicit tumour-selective killing. This Special Issue of Biomolecules highlights recent advances in our understanding of the mechanism of action of this intriguing class of viral proteins and their clinical application for the treatment of cancer and other conditions.
Prof. Dr. Mahvash Tavassoli
Prof. Dr. Jose Teodoro
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- Viral proteins
- novel therapeutics
- tumour selective cell death