Adipose Tissue in Intercellular and Interorgan Crosstalk

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 3447

Special Issue Editor

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Interests: adipocyte cell death in pathology and physiology condition; intercellular crosstalk within adipose tissue

Special Issue Information

Dear Colleagues,

There are three different kinds of adipose tissue: white adipose tissue, brown adipose tissue, and beige adipose tissue. White adipose tissue stores excess energy as lipids, whereas brown and beige adipose tissue are specific for dissipating energy as heat—a process called thermogenesis—and thus are called thermogenic adipose tissue. Excess white adipose tissue leads to systemic inflammation, concomitant with the development of insulin resistance, type 2 diabetes, and cardiovascular diseases, whereas the activation of BAT confers beneficial effects on adiposity, insulin resistance and hyperlipidemia in mice. In human studies, individuals with BAT had a lower prevalence of cardiometabolic diseases, correlated with a lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension. These studies strongly support that adipose tissues play a crucial role in the whole-body metabolism. Exploring the active biofactors secreted from adipose tissues, including adipokines and exosomes, and their function in intercellular or interorgan crosstalk will help us to understand the underlying mechanisms and identify potential therapeutic strategies to combat metabolic diseases. This Special Issue is dedicated to new or old adipokines and exosomes in intercellular or interorgan crosstalk. Submissions of original research manuscripts and review manuscripts are welcomed in (but are not limited to) the following areas:

  • Adipokines derived of all three kinds of adipose tissue;
  • Exosome derived of all three kinds of adipose tissue;
  • Intercellular crosstalk within adipose tissue;
  • Crosstalk between adipose and non-adipose tissues.

Dr. Daorong Feng
Guest Editor

Manuscript Submission Information

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Keywords

  • adipose tissue
  • intercellular crosstalk
  • interorgan cross talk
  • adipokines
  • batokines
  • exosome

Published Papers (2 papers)

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Research

12 pages, 919 KiB  
Article
Association of Serum Vaspin Concentration with Metabolic Disorders in Obese Individuals
by Łukasz Pilarski, Marta Pelczyńska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulińska and Paweł Bogdański
Biomolecules 2023, 13(3), 508; https://doi.org/10.3390/biom13030508 - 10 Mar 2023
Cited by 2 | Viewed by 1438
Abstract
Vaspin, a molecule produced in visceral adipose tissue, seems to participate in the pathogenesis of metabolic disorders. The study aimed to determine the association of vaspin concentration with metabolic disorders in obese individuals. Forty obese patients and twenty normal-weight subjects underwent biochemical (fasting [...] Read more.
Vaspin, a molecule produced in visceral adipose tissue, seems to participate in the pathogenesis of metabolic disorders. The study aimed to determine the association of vaspin concentration with metabolic disorders in obese individuals. Forty obese patients and twenty normal-weight subjects underwent biochemical (fasting glucose, insulin, lipid profile, interleukin-6, hs-CRP, vaspin concentration), blood pressure, and anthropometric measurements. The HOMA-IR index was calculated. Serum vaspin concentrations in the obese group were significantly higher than in the control group (0.82 ± 0.62 vs. 0.43 ± 0.59; p < 0.001). Among the entire population, vaspin concentration was positively correlated with body weight, BMI, WHR, and the percentage and mass of adipose tissue. Positive correlations between vaspin concentration and triglyceride level, insulin concentration, and HOMA-IR value were found. Vaspin concentration was positively correlated with hs-CRP and IL-6 levels. In obese patients, positive correlations between vaspin concentration and the percentage of adipose tissue and hs-CRP level were demonstrated. Logistic regression analysis showed that increased BMI was the biggest factor stimulating vaspin concentrations (OR = 8.5; 95% CI: 1.18–61.35; p = 0.0338). An elevated vaspin level may imply its compensatory role against metabolic disorders in obese patients. Thus, vaspin appears to be a useful diagnostic parameter for new therapeutic approaches in obesity-related complications. Nevertheless, due to the small sample size, further studies are needed to confirm our results. Full article
(This article belongs to the Special Issue Adipose Tissue in Intercellular and Interorgan Crosstalk)
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18 pages, 2252 KiB  
Article
Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study
by Giuseppina Cuttitta, Maria Ferraro, Fabio Cibella, Pietro Alfano, Salvatore Bucchieri, Angelo Maria Patti, Rosalba Muratori, Elisabetta Pace and Andreina Bruno
Biomolecules 2023, 13(1), 48; https://doi.org/10.3390/biom13010048 - 27 Dec 2022
Cited by 4 | Viewed by 1474
Abstract
Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Although inflammatory markers, body composition, and nutritional status have a significant impact on pulmonary function, the real contribution of adipocytokines and myokines in COPD is still [...] Read more.
Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Although inflammatory markers, body composition, and nutritional status have a significant impact on pulmonary function, the real contribution of adipocytokines and myokines in COPD is still controversial. We aimed to evaluate the role played by the body composition, leptin, adiponectin, haptoglobin, and irisin on the functional exercise capacity, respiratory function, and quality of life (QoL) in COPD. In 25 COPD (20% GOLD-1; 60% GOLD-2; 20% GOLD-3) patients and 26 matched control subjects, we find that leptin, total adiponectin and haptoglobin are significantly increased whereas the 6 min walk test (6MWT) and physical functioning scores are significantly decreased in COPD versus controls. A significant positive relationship is found between leptin and fat mass and between 6MWT and the good health indicators of nutritional status. A significant inverse relationship is found between 6MWT and leptin and fat mass, FEV1 and haptoglobin, and irisin and haptoglobin. Phase angle and leptin level are significant predictors for functional exercise capacity assessed with 6MWT. Taken altogether, the results of this pilot study further support the role played by body composition and adipocytokines on exercise capacity respiratory function and QoL in COPD. Full article
(This article belongs to the Special Issue Adipose Tissue in Intercellular and Interorgan Crosstalk)
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