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Biomolecules
Special Issues
The Advanced Research on Animal Nutrition and by-Product Treatment
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The Advanced Research on Animal Nutrition and by-Product Treatment

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (9 January 2023) | Viewed by 3561

Special Issue Editors

Dr. Gang Liu

E-Mail Website
Guest Editor
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, Hunan, China
Interests: animal healthy; immunity; antioxidation; bacteria; livestock pollution
Dr. Mujeeb Ur Rehman

E-Mail Website
Co-Guest Editor
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China
Interests: antimicrobial resistance; bacterial pathogenesis; microbiology
Dr. Deguang Song

E-Mail Website
Co-Guest Editor
Department of Immunobiology, Yale University, New Haven, CT, USA
Interests: microbiome; host interactions

Special Issue Information

Dear Colleagues,

The health status of livestock and their excrement during feeding can affect people's quality of life. Various factors, such as weaning stress, parasitic infestation, viral infection, or other factors, during animal feeding can affect their health status, which, in turn, directly or indirectly affects their ability to fight disease or poor meat quality. Based on this, scientists use animal, murine, or cellular models to study the health of domestic animals in order to find coping strategies or therapeutic targets. In addition, a series of by-products produced in livestock and poultry also have adverse effects on the environment. The random stacking of manure can cause water and air pollution. The overuse of antibiotics in animal feeding can accumulate in manure and pollute groundwater. It is essential to deal with these issues. This Special Issue of Biomolecules will focus on the most recent advances related to animal nutrition, immune, and livestock and poultry waste treatment. We welcome submissions of original research articles on livestock and poultry breeding.

Dr. Gang Liu
Dr. Mujeeb Ur Rehman
Dr. Deguang Song
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal healthy
  • immunity
  • antioxidation
  • bacteria
  • livestock pollution

Published Papers (2 papers)

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Research

14 pages, 5857 KiB  
Article
Downregulation of Bmal1 Expression in Celiac Ganglia Protects against Hepatic Ischemia-Reperfusion Injury
by Jiarui Feng, Lilong Zhang, Enfu Xue, Zhendong Qiu, Ning Hu, Kunpeng Wang, Yingru Su and Weixing Wang
Biomolecules 2023, 13(4), 713; https://doi.org/10.3390/biom13040713 - 21 Apr 2023
Viewed by 1465
Abstract
Hepatic ischemia-reperfusion injury (HIRI) significantly contributes to liver dysfunction following liver transplantation and hepatectomy. However, the role of the celiac ganglion (CG) in HIRI remains unclear. Adeno-associated virus was used to silence Bmal1 expression in the CG of twelve beagles that were randomly [...] Read more.
Hepatic ischemia-reperfusion injury (HIRI) significantly contributes to liver dysfunction following liver transplantation and hepatectomy. However, the role of the celiac ganglion (CG) in HIRI remains unclear. Adeno-associated virus was used to silence Bmal1 expression in the CG of twelve beagles that were randomly assigned to the Bmal1 knockdown group (KO-Bmal1) and the control group. After four weeks, a canine HIRI model was established, and CG, liver tissue, and serum samples were collected for analysis. The virus significantly downregulated Bmal1 expression in the CG. Immunofluorescence staining confirmed a lower proportion of c-fos+ and NGF+ neurons in TH+ cells in the KO-Bmal1 group than in the control group. The KO-Bmal1 group exhibited lower Suzuki scores and serum ALT and AST levels than the control group. Bmal1 knockdown significantly reduced liver fat reserve, hepatocyte apoptosis, and liver fibrosis, and it increased liver glycogen accumulation. We also observed that Bmal1 downregulation inhibited the hepatic neurotransmitter norepinephrine, neuropeptide Y levels, and sympathetic nerve activity in HIRI. Finally, we confirmed that decreased Bmal1 expression in CG reduces TNF-α, IL-1β, and MDA levels and increases GSH levels in the liver. The downregulation of Bmal1 expression in CG suppresses neural activity and improves hepatocyte injury in the beagle model after HIRI. Full article
(This article belongs to the Special Issue The Advanced Research on Animal Nutrition and by-Product Treatment)
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14 pages, 2520 KiB  
Article
Eosinophils Infiltration in Esophageal Muscularis Propria Induces Achalasia-like Esophageal Motility Disorder in Mice
by Wei Zhao, Bin Wang, Lili Zhang and Hong Jin
Biomolecules 2022, 12(12), 1865; https://doi.org/10.3390/biom12121865 - 13 Dec 2022
Cited by 1 | Viewed by 1380
Abstract
Eosinophil infiltration in esophageal muscularis propria is common in achalasia (AC). This study aims to evaluate the effect of eosinophil infiltration in muscularis propria of the esophagus on esophageal motility in mice. A mouse model with eosinophil infiltration in the esophageal muscle layer [...] Read more.
Eosinophil infiltration in esophageal muscularis propria is common in achalasia (AC). This study aims to evaluate the effect of eosinophil infiltration in muscularis propria of the esophagus on esophageal motility in mice. A mouse model with eosinophil infiltration in the esophageal muscle layer was established by long term Ovalbumin (OVA) exposure. The histopathology features of esophageal muscularis propria as well as parameters of esophageal motility, such as lower esophageal sphincter pressure (LESP) and esophageal emptying, were compared between model and control group. In addition, the histopathology and motility of esophagus at each time point in the model group were compared. The esophageal motor function severely deteriorated in the model group, mimicking the abnormal esophageal motility of AC, with more eosinophils and fewer SOX-10-IR cells in esophageal muscularis propria in the model group, compared with control. With the prolongation of OVA treatment, esophageal motility disorder was aggravated, accompanied by increased eosinophils in the the muscle layer of esophagus and decreased SOX-10-IR cells in the model group. In addition, the eosinophil count was negatively correlated with SOX-10-IR cells. Long-term exposure to OVA assisted by alum may induce eosinophil infiltration in esophageal muscularis propria, reduced SOX-10-IR cells and abnormal esophageal motility, which simulates the functional and histopathological features of some AC patients. This suggests that eosinophil infiltration in esophageal muscularis propria may play a role in the pathogenesis of a subgroup of AC. Full article
(This article belongs to the Special Issue The Advanced Research on Animal Nutrition and by-Product Treatment)
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