Special Issue "Sex Differences in Biomedical Research"
Deadline for manuscript submissions: 15 January 2024 | Viewed by 12352
Interests: lipid metabolism; lipidomic; sex differences; sex hormones; nutrition; metabolic syndrome
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Until recently, instructions or guidance on the effect of sex on basic and preclinical research were rare. Based on recent human and animal research over the past decade, it is now widely accepted that both biological and physiological functions in health and disease are influenced by sex-based differences. Some effort has recently been made to better represent women in clinical trials and to accept sex as a biological variable in biomedical research. Sex has been recognized as an important basic human variable that should be considered when planning studies in biomedical and health-related research, but much effort must still be made. For example, premenopausal women seem to have a natural protection to various disorders, probably due to circulating estrogen, since this protection disappears after menopause. However, the mechanism by which circulating estrogen would protect females from metabolic dysfunctions is still largely unknown. Importantly, the existence of sex differences in health implies that one sex has a specific factor or process that protects from disease. If that factor can be modulated, either directly or by modifying its downstream pathways, then disease development and/or progression may be tempered. Every cell in our bodies has a sex, which means that women and men are also different at the cellular level. This implies that diseases, nutrients, pollutants, and treatments may impact women and men differently. Therefore, we cannot continue to ignore sex differences in biomedical research, and considering sex as a biological variable is fundamental to perform good and efficient science.
The purpose of this Special Issue is to introduce a sex-biased approach in biomedical research. To develop more effective diagnostic, treatment, and prevention strategies, it is crucial to elucidate the molecular and cellular mechanisms and the causes underlying sex-dependent biological response in human disease.
Dr. Marion Korach-André
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- sex differences
- metabolic syndrome
- type-2 diabetes
- liver steatosis