Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.3
5.5
Journals
Biomolecules
Special Issues
Recent Advances in Anti-tumor Metal Complexes and Drug Delivery Systems
share announcement

Recent Advances in Anti-tumor Metal Complexes and Drug Delivery Systems

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2129

Special Issue Editors

Prof. Dr. Jasmina Dimitrić Marković

E-Mail Website
Guest Editor
Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia
Interests: antioxidants and oxidative stress in biological systems; modulators of oxidative stress; structural characterization of novel compounds, new ligands, and their transition metal complexes, with potential biological activity; the inhibitory potential of compounds towards major transport proteins
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Goran Kaluđerović

E-Mail Website
Guest Editor
Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, Germany
Interests: antitumor drugs; molecular oncology; drug targeting; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Dušan Dimić

E-Mail Website
Guest Editor
Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia
Interests: structural characterization of known and novel compounds with antioxidant properties; theoretical (DFT, NBO, QTAIM) analysis of transition metal complexes with bioactive ligands; molecular docking and molecular dynamics studies towards major transport proteins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, there is an increased interest in the discovery of new drugs in order to adequately increase the survival rate of patients with various types of cancer, which is among the most prominent causes of death worldwide. To overcome all potential problems with the application of leading chemotherapeutic agents, such as platinum drugs, a wide range of naturally occurring phytochemicals, and their synthetic analogs, with anticancer potential are being explored for use in cancer therapy. Much attention has been given to transition metal complexes other than platinum, which should be more effective and less toxic than the existing ones. New, promising perspectives in this area are also associated with developing so-called “targeted drug delivery systems,” which are accomplished by labeling certain carriers with biologically active molecules or receptors specifically attached to targeted cells or tissues.

This Special Issue aims to present the research in the field of the design, synthesis, structural characterization, in silico numerical simulations, and biological activity evaluation of new tumor-selective compounds and their transition metal complexes, as well as their immobilization into drug delivery systems that can provide a therapeutic dose of new compounds to different cancer cells.

We welcome original research papers and reviews, dealing with novel naturally occurring phytochemicals or synthetic analogs, their transition metal complexes, and drug delivery systems with possible applications in anticancer therapy.

Prof. Dr. Jasmina Dimitrić Marković
Prof. Dr. Goran Kaluđerović
Dr. Dušan Dimić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transition metal complexes
  • synthesis
  • structural characterization
  • biological activity
  • in silico methods
  • drug delivery

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 2600 KiB  
Article
Triphenyltin(IV) Carboxylates with Exceptionally High Cytotoxicity against Different Breast Cancer Cell Lines
by Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Peter Lönnecke, Goran N. Kaluđerović and Evamarie Hey-Hawkins
Biomolecules 2023, 13(4), 595; https://doi.org/10.3390/biom13040595 - 26 Mar 2023
Cited by 4 | Viewed by 1699
Abstract
Organotin(IV) carboxylates are a class of compounds explored as alternatives to platinum-containing chemotherapeutics due to propitious in vitro and in vivo results, and distinct mechanisms of action. In this study, triphenyltin(IV) derivatives of non-steroidal anti-inflammatory drugs (indomethacin (HIND) and flurbiprofen (HFBP)) are synthesized [...] Read more.
Organotin(IV) carboxylates are a class of compounds explored as alternatives to platinum-containing chemotherapeutics due to propitious in vitro and in vivo results, and distinct mechanisms of action. In this study, triphenyltin(IV) derivatives of non-steroidal anti-inflammatory drugs (indomethacin (HIND) and flurbiprofen (HFBP)) are synthesized and characterized, namely [Ph3Sn(IND)] and [Ph3Sn(FBP)]. The crystal structure of [Ph3Sn(IND)] reveals penta-coordination of the central tin atom with almost perfect trigonal bipyramidal geometry with phenyl groups in the equatorial positions and two axially located oxygen atoms belonging to two distinct carboxylato (IND) ligands leading to formation of a coordination polymer with bridging carboxylato ligands. Employing MTT and CV probes, the antiproliferative effects of both organotin(IV) complexes, indomethacin, and flurbiprofen were evaluated on different breast carcinoma cells (BT-474, MDA-MB-468, MCF-7 and HCC1937). [Ph3Sn(IND)] and [Ph3Sn(FBP)], unlike the inactive ligand precursors, were found extremely active towards all examined cell lines, demonstrating IC50 concentrations in the range of 0.076–0.200 µM. Flow cytometry was employed to examine the mode of action showing that neither apoptotic nor autophagic mechanisms were triggered within the first 48 h of treatment. However, both tin(IV) complexes inhibited cell proliferation potentially related to the dramatic reduction in NO production, resulting from downregulation of nitric oxide synthase (iNOS) enzyme expression. Full article
(This article belongs to the Special Issue Recent Advances in Anti-tumor Metal Complexes and Drug Delivery Systems)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop