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Biomolecules
Special Issues
Probiotics and Their Metabolites
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Special Issue "Probiotics and Their Metabolites"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 6023

Special Issue Editor

Prof. Dr. Hary Razafindralambo

E-Mail Website
Guest Editor
Gembloux Agro-Bio Tech, Liege University, Passage des déportés 2, B-5030 Gembloux, Belgium
Interests: Physical chemistry of Biological and Food systems; Prebiotic; Probiotic and Postbiotic Characterization and Applications; Synergy and Interaction Research; Biobased Compounds; Colloid and Interfacial Sciences; Formulation; Nutraceutics

Special Issue Information

Dear Colleagues,

Nowadays, probiotics are among the most investigated research topics, owing to their beneficial effects on human, animal, and plant species. These live microorganisms are able to promote host health against numerous old-known and more recent diseases. Their use as natural and safe functional ingredients is becoming essential and continuing to grow while covering a wider range of applications for food and non-food products. However, their optimal and expected performance is not always achieved without a profound understanding of their actions and interactions within various models. Competition for nutrients and adhesion sites facing pathogens, metabolite production, and immune system modulation are among the main mechanisms at the basis of their functionalities. Further efforts are therefore needed to increase our knowledge on probiotics, metabolite products, and microbe– metabolite–host interactions at the molecular level.

This special issue dedicated to these subjects is focused rather on biochemical, biophysical, bioengineering, and technological aspects than clinical trial analyses. Probiotic action modes and characterization in relation with the produced biomolecules responsible for anti-pathogens, adhesion capacity, biofilm formation and destruction, and interactions with the host will particularly be targeted. Original research articles, reviews, communications, perspectives, and opinions dedicated to the topic of probiotics and their metabolites will be welcome. The selected high-quality articles will help in making progress into the design and development of future probiotic products with better quality, properties, performance, and stability.

Prof. Dr. Hary Razafindralambo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Probiotics
  • Metabolites
  • Functionality
  • Biochemical aspects
  • Biophysical aspects
  • Physicochemical approach
  • Molecular mechanism
  • Interaction
  • Synergy
  • Adhesion
  • Colonization
  • Stability
  • Prebiotics
  • Postbiotics
  • Synbiotics
  • Viability
  • Formulation
  • Rational design
  • Human health
  • Animal health
  • Plant health

Published Papers (2 papers)

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Review
Postbiotics and Their Health Modulatory Biomolecules
by
Emma Scott
,
Kim De Paepe
and
Tom Van de Wiele
Biomolecules 2022, 12(11), 1640; https://doi.org/10.3390/biom12111640 - 04 Nov 2022
Cited by 4 | Viewed by 3210
Abstract
Postbiotics are a new category of biotics that have the potential to confer health benefits but, unlike probiotics, do not require living cells to induce health effects and thus are not subject to the food safety requirements that apply to live microorganisms. Postbiotics [...] Read more.
Postbiotics are a new category of biotics that have the potential to confer health benefits but, unlike probiotics, do not require living cells to induce health effects and thus are not subject to the food safety requirements that apply to live microorganisms. Postbiotics are defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. Postbiotic components include short-chain fatty acids, exopolysaccharides, vitamins, teichoic acids, bacteriocins, enzymes and peptides in a non-purified inactivated cell preparation. While research into postbiotics is in its infancy, there is increasing evidence that postbiotics have the potential to modulate human health. Specifically, a number of postbiotics have been shown to improve gut health by strengthening the gut barrier, reducing inflammation and promoting antimicrobial activity against gut pathogens. Additionally, research is being conducted into the potential application of postbiotics to other areas of the body, including the skin, vagina and oral cavity. The purpose of this review is to set out the current research on postbiotics, demonstrate how postbiotics are currently used in commercial products and identify a number of knowledge gaps where further research is needed to identify the potential for future applications of postbiotics. Full article
(This article belongs to the Special Issue Probiotics and Their Metabolites)
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Review
Synbiotics and Their Antioxidant Properties, Mechanisms, and Benefits on Human and Animal Health: A Narrative Review
by
Majid Mounir
,
Amal Ibijbijen
,
Kawtar Farih
,
Holy N. Rabetafika
and
Hary L. Razafindralambo
Biomolecules 2022, 12(10), 1443; https://doi.org/10.3390/biom12101443 - 09 Oct 2022
Cited by 2 | Viewed by 2013
Abstract
Antioxidants are often associated with a variety of anti-aging compounds that can ensure human and animal health longevity. Foods and diet supplements from animals and plants are the common exogenous sources of antioxidants. However, microbial-based products, including probiotics and their derivatives, have been [...] Read more.
Antioxidants are often associated with a variety of anti-aging compounds that can ensure human and animal health longevity. Foods and diet supplements from animals and plants are the common exogenous sources of antioxidants. However, microbial-based products, including probiotics and their derivatives, have been recognized for their antioxidant properties through numerous studies and clinical trials. While the number of publications on probiotic antioxidant capacities and action mechanisms is expanding, that of synbiotics combining probiotics with prebiotics is still emerging. Here, the antioxidant metabolites and properties of synbiotics, their modes of action, and their different effects on human and animal health are reviewed and discussed. Synbiotics can generate almost unlimited possibilities of antioxidant compounds, which may have superior performance compared to those of their components through additive or complementary effects, and especially by synergistic actions. Either combined with antioxidant prebiotics or not, probiotics can convert these substrates to generate antioxidant compounds with superior activities. Such synbiotic-based new routes for supplying natural antioxidants appear relevant and promising in human and animal health prevention and treatment. A better understanding of various component interactions within synbiotics is key to generating a higher quality, quantity, and bioavailability of antioxidants from these biotic sources. Full article
(This article belongs to the Special Issue Probiotics and Their Metabolites)
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