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Biomolecules
Special Issues
Involvement of Oxidative Stress Signalling Pathways in Cell Death
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Involvement of Oxidative Stress Signalling Pathways in Cell Death

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 6688

Special Issue Editors

Dr. Sara Salucci

E-Mail Website
Guest Editor
Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), 40126 Bologna, Italy
Interests: apoptosis; necrosis; autophagy; oxidative stress; anticancer drugs; extracellular vescicles; in vitro cell cultures; ultrastructural analyses; immunohistochemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Michela Battistelli

E-Mail Website
Guest Editor
Department of Biomolecular Sciences, Urbino University 61029, Urbino, Italy
Interests: apoptotic cell death; chondroptosis; oxidative damage; extracellular vesicles; ultrastructural analyses; rheumatic diseases; biological fluid and biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) play a key role as a second messenger by modulating multiple signaling pathways under physiological and pathological conditions. ROS are constantly produced in aerobic cells or are generated during a number of processes, such as inflammation, infection, chemical stresses, and exposure to UV rays and ionizing radiation. Basal levels of ROS act as signaling molecules to activate cell proliferation, survival, apoptosis, differentiation, immune responses, motility, and other pathways. High ROS levels can cause an imbalance of prooxidants and antioxidant systems in the body and can induce damage to DNA, protein, and lipids which, if unrepaired, lead to mutations and promote carcinogenesis or a deregulated cell death.

The goal of this Special Issue is to publish the latest research advancements in the knowledge of cell death signaling pathways correlated with oxidative stress, which could be crucial for identifying new molecular targets involved in the occurrence and development of a variety of diseases such as cancer, arteriosclerosis, osteoarthritis, osteoporosis and neurodegenerative disorders, in which a crosstalk between ROS and cell death has been described, even if the molecular mechanisms are not fully understood. 

Dr. Sara Salucci
Dr. Michela Battistelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell death
  • oxidative stress
  • molecular pathways
  • health
  • disease

Published Papers (3 papers)

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Research

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16 pages, 1839 KiB  
Article
Weak Radiofrequency Field Effects on Chemical Parameters That Characterize Oxidative Stress in Human Fibrosarcoma and Fibroblast Cells
by Hakki Gurhan, Marek Bajtoš and Frank Barnes
Biomolecules 2023, 13(7), 1112; https://doi.org/10.3390/biom13071112 - 13 Jul 2023
Cited by 1 | Viewed by 1814
Abstract
In the last few decades, evidence has surfaced that weak radiofrequency (RF) fields can influence biological systems. This work aims to improve our understanding of how externally applied weak RF fields alter concentrations of chemical parameters that characterize oxidative stress. We conducted a [...] Read more.
In the last few decades, evidence has surfaced that weak radiofrequency (RF) fields can influence biological systems. This work aims to improve our understanding of how externally applied weak RF fields alter concentrations of chemical parameters that characterize oxidative stress. We conducted a series of experiments to investigate the effects of applying weak RF magnetic fields within the 3–5 MHz region on mitochondrial respiration in both human fibrosarcoma and fibroblast cells over a period of four days. Our experimental data show that RF fields between 3 and 5 MHz were able to change the modulation of mitochondrial signaling by changing the cell growth, mitochondrial mass, and oxidative stress. Exposure to RF fields at 4.2 MHz significantly increased the mitochondrial mass and oxidative stress in fibrosarcoma cells. There are substantial concerns that extended exposure to weak RF fields can lead to health effects. The ability to control these parameters by external magnetic fields may have important clinical implications. Full article
(This article belongs to the Special Issue Involvement of Oxidative Stress Signalling Pathways in Cell Death)
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19 pages, 2948 KiB  
Article
Carrying Temoporfin with Human Serum Albumin: A New Perspective for Photodynamic Application in Head and Neck Cancer
by Edoardo Jun Mattioli, Luca Ulfo, Alessia Marconi, Valentina Pellicioni, Paolo Emidio Costantini, Tainah Dorina Marforio, Matteo Di Giosia, Alberto Danielli, Carmela Fimognari, Eleonora Turrini and Matteo Calvaresi
Biomolecules 2023, 13(1), 68; https://doi.org/10.3390/biom13010068 - 29 Dec 2022
Cited by 8 | Viewed by 2539
Abstract
Temoporfin (mTHPC) is approved in Europe for the photodynamic treatment of head and neck squamous cell carcinoma (HNSCC). Although it has a promising profile, its lipophilic character hampers the full exploitation of its potential due to high tendency of aggregation and a reduced [...] Read more.
Temoporfin (mTHPC) is approved in Europe for the photodynamic treatment of head and neck squamous cell carcinoma (HNSCC). Although it has a promising profile, its lipophilic character hampers the full exploitation of its potential due to high tendency of aggregation and a reduced ROS generation that compromise photodynamic therapy (PDT) efficacy. Moreover, for its clinical administration, mTHPC requires the presence of ethanol and propylene glycol as solvents, often causing adverse effects in the site of injection. In this paper we explored the efficiency of a new mTHPC formulation that uses human serum albumin (HSA) to disperse the photosensitizer in solution (mTHPC@HSA), investigating its anticancer potential in two HNSCC cell lines. Through a comprehensive characterization, we demonstrated that mTHPC@HSA is stable in physiological environment, does not aggregate, and is extremely efficient in PDT performance, due to its high singlet oxygen generation and the high dispersion as monomolecular form in HSA. This is supported by the computational identification of the specific binding pocket of mTHPC in HSA. Moreover, mTHPC@HSA-PDT induces cytotoxicity in both HNSCC cell lines, increasing intracellular ROS generation and the number of γ-H2AX foci, a cellular event involved in the global response to cellular stress. Taken together these results highlight the promising phototoxic profile of the complex, prompting further studies to assess its clinical potential. Full article
(This article belongs to the Special Issue Involvement of Oxidative Stress Signalling Pathways in Cell Death)
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Review

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14 pages, 995 KiB  
Review
Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine
by Valeria Pizzuti, Francesca Paris, Pasquale Marrazzo, Laura Bonsi and Francesco Alviano
Biomolecules 2023, 13(6), 971; https://doi.org/10.3390/biom13060971 - 10 Jun 2023
Cited by 2 | Viewed by 1508
Abstract
Oxidative stress (OS) occurs when the production of reactive oxygen species (ROS) is not balanced by the body’s antioxidant defense system. OS can profoundly affect cellular health and function. ROS can have a profound negative impact on cells that undergo a predestined and [...] Read more.
Oxidative stress (OS) occurs when the production of reactive oxygen species (ROS) is not balanced by the body’s antioxidant defense system. OS can profoundly affect cellular health and function. ROS can have a profound negative impact on cells that undergo a predestined and time-regulated process of proliferation or differentiation, such as perinatal stem cells. Due to the large-scale employment of these immunotolerant stem cells in regenerative medicine, it is important to reduce OS to prevent them from losing function and increase their application in the regenerative medicine field. This goal can be achieved through a variety of strategies, such as the use of antioxidants and other compounds that can indirectly modulate the antioxidant defense system by enhancing cellular stress response pathways, including autophagy and mitochondrial function, thereby reducing ROS levels. This review aims to summarize information regarding OS mechanisms in perinatal stem cells and possible strategies for reducing their deleterious effects. Full article
(This article belongs to the Special Issue Involvement of Oxidative Stress Signalling Pathways in Cell Death)
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