Organic Cation Transporters
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: closed (28 March 2023) | Viewed by 3967
Special Issue Editors
Interests: drug metabolism; drug membrane transport and clinical pharmacokinetics; pharmacogenetics and pharmacogenomics; biochemical pharmacology
Interests: blood–brain barrier; neurovascular unit; Blood-retina barrier; drug transporters; brain drug delivery; SLC and ABC transporters; pharmacokinetics
Special Issue Information
Dear Colleagues,
Looking at publication frequencies, research on organic cation transporters (OCTs) still seems to be outshined by research on organic anion transporters (OATs) and ABC transporters (ABCs) (https://pubmed.ncbi.nlm.nih.gov), although probably one-third of all low-molecular-weight drugs are organic cations. With this Special Issue of Biomolecules, we would like to promote progress and cooperation in OCT research. We are particularly looking for original contributions and reviews in the following four fields in OCT research:
1) All about biochemical pharmacology of OCTs. Notably, for the majority of organic cations even the genetic identity of the pharmacokinetically relevant OCTs has not yet been revealed.
2) Classical and advanced approaches in bioinformatics related to OCTs. That should allow a comprehensive understanding of substrate spectra of OCTs and molecular interactions between OCTs and their substrates.
3) Regulation of the expression and activity of organic cation transporters by genetics, epigenetics and environmental factors. Additionally, the organ-specific versus ubiquitous expression of OCTs is still not well understood. Improvements to this knowledge would help to understand variation in pharmacokinetics and in the therapeutics or adverse effects of cationic drugs.
4) More about the role OCTs play in the disposition of endogenous molecules and of molecules from microbial and plant metabolomes to which we are always exposed from nutrition and from our microbiomes in health and disease.
Of course, other suggestions and contributions to the understanding of OCTs are also welcome.
With best wishes,
Prof. Dr. Jürgen Brockmöller
Prof. Dr. Salvatore Cisternino
Guest Editors
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Keywords
- organic cation transporters
- OCT
- solute carriers
- SLC
- blood-brain barrier
- pharmacokinetic modelling
- structural biology
- metabolomics
- transcriptional regulation