Targeting Neuroinflammation and Insulin Resistance for a Healthy Brain: Prevention and Treatment of Neurological and Psychiatric Disorders
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 380
Special Issue Editors
Interests: neuroinflammation; psychiatric disorders; insulin resistance; chitosan nanoparticles; AAV particles; non-coding RNA; animal models; cell culture
Special Issues, Collections and Topics in MDPI journals
Interests: neuroscience; brain circuits; behaviour; cell culture; western blot; immunohistochemistry; insulin resistance; neuroinflammation; ADHD; learning and memory; microscopy
Special Issue Information
Dear Colleagues,
Neuroinflammation and insulin resistance form a bidirectional process that induces neuronal damage. Inflammatory events and insulin resistance have been associated with the onset of neurodegenerative pathologies, including late-onset Alzheimer’s disease and Parkinson’s disease. Accumulating evidence indicates that neuroinflammation and insulin resistance can also underlie psychiatric disorders. Several conditions, ranging from emotional stress to metabolic syndrome, including traumatic brain injury, chronic infections, or gut dysbiosis, can cause or aggravate insulin resistance and neuroinflammation.
The Western lifestyle is characterized by stress, sedentarism, and high caloric intake, which increases the risk of suffering from diverse brain disorders. Interventions that reduce neuroinflammation and improve insulin signaling (i.e., physical exercise, nutrition supplementation) can improve synaptic plasticity and brain cognitive function.
Review articles and original research papers, showing novel mechanisms underlying the association of neuroinflammation and brain insulin resistance with brain dysfunction and showing evidence of novel biomarkers or genetic predisposition are welcome. We invite contributions raising the knowledge and awareness of the need for early intervention in controlling neuroinflammation and insulin resistance to improve neurological and psychiatric disorders’ management.
Dr. Ana María Sánchez-Pérez
Dr. Sandra Sánchez-Sarasúa
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- insulin receptor substrates
- microglia
- degenerative diseases
- psychiatric disorders
- nutrition
