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Special Issue "HSP70: From Signaling Mechanisms to Therapeutics"
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 6612
Special Issue Editors
Interests: vascular function and dysfunction; diabetes; hypertension; DAMPS; TLR4; HSP70 homeostasis; oxidative stress; ED
Interests: cardiovascular function and dysfunction; diabetes; hypertension
Special Issue Information
Heat shock protein 70 (HSP70) is a chaperone molecule present in virtually all living organisms. The biological significance of this protein is widely recognized not only because it enables proteostasis, but also because HSP70 influences many other biological processes, such as redox balance, cell survival, inflammation, and calcium homeostasis, to name a few. In this sense, it is of little surprise that alterations in HSP70-related mechanisms contribute to disease development. However, we are just beginning to understand HSP70’s non-canonical roles, which calls for additional investigation. HSP70 has been implicated in the processes underlying various conditions, including aging, diabetes, hypertension, heart failure, neurodegenerative disorders, and cancer. The range of applications of this protein spans from serving as a disease biomarker to providing new interventional targets. As such, this Special Issue aims to deepen our understanding of HSP70-mediated processes in human diseases. Our goal is to deliver a forum for scientists to discuss HSP70 signaling mechanisms and biomarker potential, as well as novel therapeutics targeting this chaperone molecule. Research articles and short communications reporting preclinical results and clinical findings are welcome. We also welcome review articles, including that those are topical summaries of the literature with relevant new insights into the field.
We look forward to receiving your contributions.
Dr. Kenia Pedrosa Nunes
Dr. Amanda Almeida De Oliveira
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- protein homeostasis
- neurodegenerative disorders
- vascular dysfunction
- oxidative stress
- molecular mechanism
- stress-induced cancer