Yeast Models for Gene Regulation
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 30256
Special Issue Editors
Interests: DNA repair; replication; recombination; gene expression; epigenetics; gene expression and chromatin biology; gene regulation; DNA damage
Interests: gene expression; chromatin structure; mRNA export
Special Issue Information
Dear Colleagues,
Gene regulation, a pivotal biological process by which cells adopt environmental fluctuations, is accompanied by a variety of regulatory phases, including transcription regulation via chromatin modulation and post-transcriptional mRNA regulation (e.g., export, translation and decay). Chromatin, consisting of nucleosomes, generally inhibits DNA-related reactions by preventing the access of transacting factors to DNA substrates. Gene transcription, an initial step of gene regulation, is thus affected by chromatin configuration through the accessibility of transcription factors. The selection of transcription factor binding sites is further regulated through other layers of chromosome geometry, including 3D genome architecture. In addition, the transcribed mRNA is targeted for the next phases of gene regulation. A variety of RNA-binding proteins are recruited to the newly synthesized mRNA and modulate their expression level via processing, export and decay rate regulation. mRNA–protein complexes (mRNPs) are dynamically remodeled for establishing the cytoplasmic regulations (localization, translation and degradation). The final output of gene expression level is strictly regulated by the interconnection of these regulations. Yeast models with powerful genetics and biotechnologies have contributed to our understanding of these complicated biological processes for decades. This Special Issue is focused on all phases of yeast gene regulation and collects research articles and reviews for recent findings in gene regulation.
Prof. Dr. Kouji Hirota
Dr. Ryuta Asada
Guest Editors
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Keywords
- gene expression regulation
- chromatin
- transcription factors
- non-coding RNA
- RNA-binding proteins
- mRNA export
- translation control
- mRNA degradation