Special Issue "Biomolecules of Legionella – Tiny Parts Building the Virulence Machinery"
Deadline for manuscript submissions: closed (15 July 2022) | Viewed by 10341
In the next year, microbiologists will acknowledge the 45th anniversary of the first description of Legionella pneumophila and the establishment of its role as an infectious agent of a human disease (McDade et al., 1977). The amazing achievements that followed include deciphering of the virulence of the bacterium as an interplay of highly specialised molecules synthesised inside the microorganism and delivered to eukaryotic hosts. This paradigm soon became widely adopted as a general concept of bacterium–host cell interaction, and Legionella has been recognised as a model organism. Synthesised by Legionella, biomolecules turned out to be remarkably diverse in their nature, mechanisms, structures, targets and their effects on eukaryotic cell physiology. Their concerted action shapes the virulence capability of the pathogen and results in the fine modulation of host cell activities, ultimately allowing successful proliferation of the bacterium inside the occupied niche. Excellent reviews and exciting experimental papers are available and are dedicated to processes manipulated by Legionella products. However, in this Special Issue, I would like to “come back to the roots” and to illuminate the individual properties of the biomolecules—effectors, nucleic acids, enzymes, microbial surface structures— that are created for the smooth running of the virulence machinery.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: biochemistry, genetics, molecular biology, and structural biology. I look forward to receiving your contributions.
Dr. Yury Belyi
Manuscript Submission Information
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- protein effector
- secretion system
- molecular mechanism