Multi-Omics approach to Explore Adipose Tissue Metabolism
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 517
Special Issue Editors
2. Bonds Biosystems, Natick, MA, USA
Interests: 3D culture and organ in a chip; visceral adipose tissue remodeling; single nucleus RNA-seq and spatial transcriptome; disease modeling; iPSC-derived adipocytes
Interests: obesity; diabetes; adipogenesis; adipose tissue metabolism
Interests: obesity; adipose tissue plasticity; inflammation; adipose tissue dysfunction; adipose tissue imaging
Special Issue Information
Dear Colleagues,
To study the complex biological processes holistically, it is imperative to take an integrative approach that combines multi-omics data to highlight the active biomolecules interrelationships and functions. With the advent of high-throughput techniques and the availability of multi-omics data generated from a large set of samples, several promising tools and methods have been developed for data integration and interpretation.
Nowadays, adipose tissue has been described as a highly plastic organ with a remarkable ability to adapt to the organism's metabolic conditions. White adipose tissue (WAT) can expand to store metabolic energy as lipids, and during times of low-calorie intake, releases the stored fatty acids to support other tissue's metabolic needs. Metabolic syndrome is a common metabolic disorder, which clusters conditions such as obesity, insulin resistance, hypertension and hyperlipidemia, and increases the risk of cardiovascular diseases, stroke, and type 2 diabetes. These metabolic disorders are associated with adipose tissue dysfunction. Thus, detailed insight into the changes in individual cell types in WAT during the development of such metabolic diseases is essential for understanding the cellular and molecular mechanisms driving WAT plasticity and the associated comorbidities.
This Special Issue's primary interests are in manuscripts that report original adipose tissue plasticity, mechanistic studies that employ single-cell analyses, spatial transcriptomics, and organoids from adipose tissue. Manuscripts that report other complex co-culture systems or cell-based methods allowing the detection, measurement, and visualization of complex crosstalk mechanisms in adipose tissue plasticity in cellular level, as well as in forms of "deconstructed" organs, will also be very welcome.
Dr. Miguel Luiz Batista Jr.
Dr. Tova Meshulam
Dr. Anitta Kinga Sárvári
Dr. Felipe Henriques
Guest Editors
Manuscript Submission Information
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Keywords
- adipose tissue
- immunometabolism
- scRNA-seq
- snRNA-Seq
- epigenetics
- proteomics
- metabolomics
- interactome
