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Biomolecules
Special Issues
Impact of Infection on the Brain in Development and Adulthood
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Impact of Infection on the Brain in Development and Adulthood

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 2182

Special Issue Editors

Dr. Hervé Boutin

E-Mail Website
Guest Editor
Wolfson Molecular Imaging Centre, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, 27 Palatine Road, Manchester M20 3LJ, UK
Interests: neuroinflammation; PET imaging; Alzheimer’s disease; stroke; comorbidities; tracer development; MR imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Xuexian Yang

E-Mail Website
Guest Editor
Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, Albuquerque, NM, USA
Interests: cytokine signaling; unfolded protein response; transcriptional control; T helper cell; immunity and inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit to a Special Issue about the “Impact of Infection on the Brain in Development and Adulthood”.

There is much evidence in neuropsychiatry—the most famous example being schizophrenia—that infection has an effect on the brain in early life and may possibly lead to brain disorders later in life. In neurodegenerative diseases, this has been far less investigated, and the evidence is scarce. In either case, mechanisms linking infection and brain disorders in early life and associated impacts in later life remain under-investigated and poorly understood.

This Special Issue aims to gather research or review manuscripts dealing with these questions.

Research areas may include (but are not limited to) the following: experimental models using viral (COVID-19 or others) or bacterial infection and its impact on neuropsychiatry and neurodegeneration models; clinical studies looking retrospectively or prospectively in cohorts of patients; and imaging studies aiming to develop methods or contrast agents to image infection and/or inflammation in the context brain disorders.

We look forward to receiving your contributions.

You may choose our Joint Special Issue in Journal of Developmental Biology.

Dr. Hervé Boutin
Dr. Xuexian Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infection
  • viral
  • bacterial
  • neuroinflammation
  • neurodevelopment
  • neurodegeneration

Published Papers (1 paper)

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Research

27 pages, 2248 KiB  
Article
Maternal Immune Activation Induces Adolescent Cognitive Deficits Preceded by Developmental Perturbations in Cortical Reelin Signalling
by Rebecca M. Woods, Jarred M. Lorusso, Isabella Harris, Hager M. Kowash, Christopher Murgatroyd, Joanna C. Neill, Jocelyn D. Glazier, Michael Harte and Reinmar Hager
Biomolecules 2023, 13(3), 489; https://doi.org/10.3390/biom13030489 - 07 Mar 2023
Cited by 1 | Viewed by 1881
Abstract
Exposure to maternal immune activation (MIA) in utero significantly elevates the risk of developing schizophrenia and other neurodevelopmental disorders. To understand the biological mechanisms underlying the link between MIA and increased risk, preclinical animal models have focussed on specific signalling pathways in the [...] Read more.
Exposure to maternal immune activation (MIA) in utero significantly elevates the risk of developing schizophrenia and other neurodevelopmental disorders. To understand the biological mechanisms underlying the link between MIA and increased risk, preclinical animal models have focussed on specific signalling pathways in the brain that mediate symptoms associated with neurodevelopmental disorders such as cognitive dysfunction. Reelin signalling in multiple brain regions is involved in neuronal migration, synaptic plasticity and long-term potentiation, and has been implicated in cognitive deficits. However, how regulation of Reelin expression is affected by MIA across cortical development and associated cognitive functions remains largely unclear. Using a MIA rat model, here we demonstrate cognitive deficits in adolescent object-location memory in MIA offspring and reductions in Reln expression prenatally and in the adult prefrontal cortex. Further, developmental disturbances in gene/protein expression and DNA methylation of downstream signalling components occurred subsequent to MIA-induced Reelin dysregulation and prior to cognitive deficits. We propose that MIA-induced dysregulation of Reelin signalling contributes to the emergence of prefrontal cortex-mediated cognitive deficits through altered NMDA receptor function, resulting in inefficient long-term potentiation. Our data suggest a developmental window during which attenuation of Reelin signalling may provide a possible therapeutic target. Full article
(This article belongs to the Special Issue Impact of Infection on the Brain in Development and Adulthood)
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