Special Issue "mRNA Metabolism in Health and Disease 2.0"
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 8979
Interests: nonsense-mediated mRNA decay; mRNA translational control
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The eukaryotic gene expression pathway involves a number of interlinked steps, in which messenger RNAs (mRNAs) that code for proteins and noncoding RNAs are the key intermediates. In the nucleus, the mRNA precursor is transcribed from DNA and processed, and the mature mRNA is then exported to the cytoplasm, where it is translated into protein and finally degraded. In this process, mRNAs are associated with RNA-binding proteins forming messenger ribonucleoprotein (mRNP) complexes, whose protein content evolves throughout the lifetime of the mRNA. This mRNP assembly is important for all steps of the mRNA metabolism, and is of crucial importance for correct gene expression, which is necessary to maintain cellular homeostasis. In addition, during the complex life of mRNA, cells tightly control the quality and quantity of mRNAs using various surveillance pathways. Among these is nonsense-mediated mRNA decay, which detects and degrades mRNAs carrying premature translation-termination codons introduced through DNA mutations or pre-mRNA processing defects. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure of mRNA, modulate different steps of mRNA metabolism, and control gene expression.
This Special Issue on "mRNA Metabolism in Health and Disease" aims to provide up-to-date insight into the remarkable complexity of the mRNA metabolism, as well as on its dysregulation in the context of many different human diseases, spanning from neurological, metabolic, and cardiovascular diseases to cancer.
Dr. Luísa Romão
Manuscript Submission Information
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- mRNA metabolism
- RNA processing
- mRNA export and localization
- mRNA translation
- mRNA surveillance
- mRNA decay
- mRNA modifications
- gene expression regulation
- human genetic disease