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Biomedicines
Special Issues
Glucose Metabolism: Molecular Basis and Novel Therapies of Diabetic Complication
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Special Issue "Glucose Metabolism: Molecular Basis and Novel Therapies of Diabetic Complication"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 512

Special Issue Editors

Prof. Dr. Hendrik Lehnert

E-Mail Website
Guest Editor
1. Department of Internal Medicine I, University of Lübeck, Lübeck, Germany
2. Rektorat, Paris Lodron Universität Salzburg, Salzburg, Austria
Interests: obesity; diabetes and cancer; cognitive dysfunction
Prof. Dr. Sebastian M. Meyhöfer

E-Mail Website
Guest Editor
1. Institute of Endocrinology and Diabetes, University of Lübeck, D-23538 Lübeck, Germany
2. German Center of Diabetes Research, D-85764 Neuherberg, Germany
Interests: obesity; hypoglycemia; circadian rhythms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sebastian Meyhoefer and I are delighted to invite you to contribute a manuscript for a Special Issue of Biomedicines.

The title of this issue will be Glucose Metabolism: Molecular Basis and Novel Therapies of Diabetic Complications and it will address important topics such as the genetic and phenotypic heterogeneity of diabetes as an underlying mechanisms for differential complications settings, the mechanistic basis for disturbed hypoglycemia awareness and cognitive defects, the causal link between diabetes and tumorigenesis or the impact on lipid metabolism and cardiovascular sequelae.

We are convinced that this issue will shed further light on our knowledge of the mechanistic basis of diabetic complications and will also improve our understanding of how to therapeutically tackle these problems, based on a personalized approach that takes the heterogeneity of diabetes into account.

We are very much looking forward to receiving your contribution,

With warm regards

Prof. Dr. Hendrik Lehnert
Prof. Dr. Sebastian M. Meyhöfer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic complications
  • genetic and phenotypic heterogeneity
  • cognitive defects
  • hypoglycemia
  • diabetes and cancer
  • lipid metabolism
  • cardiovascular complications

Published Papers (1 paper)

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Research

11 pages, 1329 KiB  
Article
Association between Diabetes and Levels of Micronutrients in Qatar—A Case–Control Study
by
Nada Soliman
,
Ruba Almishal
,
Basant Elsayed
,
Ayaaz Ahmed
,
Sara Al-Amri
,
Aisha Al-Kuwari
,
Shaikha Al-Muhannadi
,
Muhammed Nadeer
and
Tawanda Chivese
Biomedicines 2023, 11(11), 3045; https://doi.org/10.3390/biomedicines11113045 - 14 Nov 2023
Viewed by 347
Abstract
Objective: The objectives of this study were to investigate associations between micronutrient levels and diabetes and to explore the association in individuals with controlled and uncontrolled diabetes. Methods: A case–control study, matched on age and gender, was performed on participants with (cases) and [...] Read more.
Objective: The objectives of this study were to investigate associations between micronutrient levels and diabetes and to explore the association in individuals with controlled and uncontrolled diabetes. Methods: A case–control study, matched on age and gender, was performed on participants with (cases) and without diabetes (controls), who were Qatari or long-term residents (≥15 years of residence). Participants with diabetes were divided into those with controlled and uncontrolled diabetes using an HbA1c cutoff of 7%. Levels of micronutrients were measured from serum and categorized into normal and abnormal levels. Results: A total of 1118 participants (374 cases and 744 controls) were included with a mean age of 41.7 years (SD 9.9), of whom 53.9% were female. Of those with diabetes, 229 had controlled diabetes and 145 had uncontrolled diabetes. Compared to those without diabetes, participants with diabetes had significantly lower mean magnesium (0.80 mmol/L (SD 0.07) vs. 0.84 mmol/L (SD 0.06), respectively, p < 0.001). Lower magnesium and iron were observed in participants with uncontrolled compared to participants with controlled diabetes. After multivariable logistic regression, diabetes was associated with hypomagnesemia (OR 3.2, 95% CI 3.4–213.9) and low iron (OR 1.49, 95% CI 1.03–2.15). Uncontrolled diabetes showed stronger odds of association with hypomagnesemia (OR 5.57, 95% CI 3.65–8.52). Conclusion: In an affluent setting in the MENA region, diabetes was associated with low magnesium and low iron, and this association was stronger in individuals with uncontrolled diabetes. Full article
(This article belongs to the Special Issue Glucose Metabolism: Molecular Basis and Novel Therapies of Diabetic Complication)
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