Special Issue "The Role of the Immune System in Kidney Disease: Advances in Mechanisms and Therapeutics"
Deadline for manuscript submissions: 31 March 2024 | Viewed by 167
2. Bicêtre Hospital, Department of Nephrology, 78 Rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France
3. INSERM UMR 1197, 14 avenue Paul Vaillant Couturier, 94807 Villejuif, France
Interests: cell death; senescence; autophagy; DNA damage; stem cells; pathogenesis of renal disorder; molecular medicine; immunology of transplantation
The kidney is a vital organ with multiple functions for the organism, including the filtration of toxic substances from serum and the regulation of blood pressure or hematopoiesis. There is a very close relationship between the kidney and the immune system. It is well known that the immune system may be at the origin of many variants of kidney diseases, either directly or indirectly. For example, immune system dysregulation, involving the production of autoantibodies, is the cause of diseases, such as IgA glomerulopathies, lupus nephropathy, ANCA-associated vasculitis, or membranous nephropathy. In other cases, lymphocyte destabilization can secret the serum of circulating factors at the origin of glomerulopathies such as FSGS. Even more paradigmatic is the example of the immune response to renal transplantation, the control of which is one of the workhorses of nephrologists. In recent decades, much progress has been made in the mechanisms of the allogeneic response and immunosuppression, which has opened up new avenues of study with great therapeutic potential.
The aim of this Special Issue is to compile emerging research in the field of immunology related to kidney disease. The spectrum of studies is very broad, but always within the effects of the immune system on the kidney. In addition, therapeutic applications for the treatment of immune-mediated nephropathies, including those resulting from kidney transplantation, are welcomed.
Dr. Hans-Kristian Lorenzo
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- kidney transplantation
- immune homeostasis
- kidney disease