The Role of Cytokines in Health and Disease: 2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 1012

Special Issue Editor

Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland
Interests: neurodegenerative diseases; cancer; specific proteins; cytokines; biomarkers; non-invasive diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue predominantly covers the usefulness of the determination of cytokines in healthy patients and patients with civilization diseases, with a particular emphasis on neurodegenerative and neoplastic diseases. Despite being non-contagious, civilization diseases are often referred to as the epidemics of the 21st century because they spread globally and lead to over 80% of premature deaths. For many years, it has been observed that society is progressively ageing, which results in an increase in the number of elderly people who are most at risk of developing degenerative diseases of the central nervous system, as well as cancer. As part of this Special Issue, we are looking for new indicators allowing for early detection (even in potentially healthy patients, years before the first symptoms of the emerging disease), and thus a better prognosis of the survival of patients with selected civilization diseases. It is assumed that the introduction of the concentrations of the analyzed proteins to the diagnosis of patients with civilization diseases may facilitate the diagnosis and differentiation of these diseases, and thus enable the early initiation of treatment.

This Special Issue aims to comprehensively study the role of cytokines in health and in various diseases (mainly, but not only, the diseases of civilization, such as cancers or neurodegenerative diseases). Moreover, the aim of this Special Issue is also to understand the involvement of different cytokine groups in diagnosis and/or therapy and to investigate the new potential therapies targeting cytokines. In this Special Issue, original research articles and reviews are welcome.

Research areas may include (but are not limited to) the following:

  • Cytokines as prognostic factors of different diseases;
  • Cytokines as novel tumor markers in malignant tumors;
  • Cytokines in neurodegeneration;
  • Cytokines in neuroinflammation;
  • Cytokines in COVID-19;
  • Potential novel role of cytokines in health and disease.

I look forward to receiving your contributions. 

Dr. Monika Zajkowska
Guest Editor

Manuscript Submission Information

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  • cytokine
  • chemokine
  • neurodegenerative disease
  • cancer
  • inflammatory mediator
  • diagnosis
  • biomarker

Published Papers (1 paper)

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19 pages, 965 KiB  
The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis
Biomedicines 2024, 12(2), 428; - 13 Feb 2024
Viewed by 619
Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines [...] Read more.
Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR. Methods: European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), “The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire” (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay. Results: The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; p < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; p < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β (p = 0.002), IL-6 (p = 0.031), IL-8 (p < 0.001), IL17-A (p = 0.013) and IL-18 (p = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly (p < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR. Conclusions: This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research. Full article
(This article belongs to the Special Issue The Role of Cytokines in Health and Disease: 2nd Edition)
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