Special Issue "CAR T-Cell Therapy for AML"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 38

Special Issue Editor

Dr. Vincenzo Maria Perriello
E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Perugia, 06131 Perugia, Italy
Interests: hemato-oncology; acute myeloid leukemia; immunotherapy; CAR-T cell development; tumor target antigen discovery

Special Issue Information

Dear Colleagues,

Recent advances in the molecular profiling of acute myeloid leukemia (AML) has refined prognostic risk stratification, improved minimal residual disease monitoring and personalized treatment options with new precision drugs. Despite these substantial improvements, up to 70% of adults and 30% of children with AML still relapse after initial responses and do not survive beyond five years.

Chimeric antigen receptor (CAR) T cells have dramatically improved the outcome of patients with high-risk B cell malignancies, while their successful deployment for other malignancies such as AML remains an open challenge. So far, antigen selection is the most significant barrier restricting the therapeutic application of CAR T cells in AML. Novel CARs redirected against unexplored AML targets recently proved to be specific in preclinical models, while selective AML antigen combinations have been proposed for dual targeting strategies exploiting high-throughput approaches. However, differential expression between leukemic and normal hematopoietic cells should not be the only parameter to select targets for immunotherapy in a highly heterogeneous genotypic and phenotypic cancer as AML. Thus, AML targets should be ideally integral to leukemic functions, especially considering antigen loss or downregulation as a major mechanism of relapse after CAR-T cell therapy.

I hope that this Special Issue will contribute to the dissemination of original research and comprehensive reviews of the exploration of novel AML targets, mechanisms of CAR-T cell failure in AML and strategies to overcome these issues.

Dr. Vincenzo Maria Perriello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chimeric antigen t cells
  • acute myeloid leukemia
  • immunotherapy
  • adoptive cell therapy
  • gene therapy
  • T cell receptor (TCR)-based therapy
  • leukemic stem cells
  • leukemia target antigens
  • tumor microenvironment

Published Papers

This special issue is now open for submission.
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