Special Issue "Impact of 3'UTR Variants on mRNA Stability"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 138

Special Issue Editors

Experimental Nephrology Lab, Institut d’Investigació Biomèdica de Bellvitge-IDIBELL, C/ Feixa Llarga s/n, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
Interests: molecular medicine; predictive medicine; personalized medicine; inflammation; ncRNAs
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Special Issue Information

Dear Colleagues,

Recent years have seen a huge increase in the number of works describing the nature and function of newly described regulatory RNAs. This knowledge has allowed for the delineation of complex regulatory networks that relate mRNAs’ stability to the expression of microRNAs (miRNAs) and lncRNAs (as miRNA sponges).

Additionally, a number of authors have recently described a new functional feature of mRNAs that directly impacts the establishment of these RNA regulatory networks, i.e., the dynamic expression of different 3’UTR isoforms to regulate the accession of miRNAs to their target mRNA sequences.

In this Special Issue we are interested in the mechanisms that generate 3’UTR diversity in normal and disease cells (such as alternative polyadenylation, alternative splicing, or the exonization of repetitive elements), in addition to their impact on mRNA function. Furthermore, we are also especially interested in the use of alternative 3’UTRs for the stabilization of mRNA vaccines.

We are also willing to receive originals on technical developments that have facilitated the generation as well as analysis of transcriptonic information of 3’UTR variants and their impact on mRNA stability and function:

  • Development of software to extract variant 3’UTR data from RNA.seq/single-cell RNA.seq runs;
  • Generation of databases of variant 3’UTRs in human diseases;
  • New experimental techniques for the high-throughput targeting of mRNA–miRNA as well as miRNA–lncRNA interactions;
  • Software for modeling mRNA–miRNA–lncRNA networks, including alternative 3’UTRs

Dr. Estanislao Navarro
Dr. Miguel Hueso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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