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Special Issue "30 Years of OPN Milestones and Future Avenues 2.0"
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 August 2023 | Viewed by 3886
Special Issue Editor
Interests: autoimmune diseases; liquid biopsy biomarkers; immunology; nanomaterial biocompatibility; flow cytometry; microvesicles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
This Commemorative Issue will collect all contributions pertaining the multifaceted roles of osteopontin (OPN), discovered 30 years ago. In the nineties, OPN was identified in human bone as an immobilized extracellular matrix protein, but since then, further studies have shown that OPN also acts as a soluble cytokine in body fluids, and it has been linked to various physiological and pathological processes. OPN mediates bone remodeling, macrophage response, cell migration and adhesion, inflammation and Th1 and Th17 cell differentiation. Moreover, OPN is involved in tumor angiogenesis and metastatic dissemination. To date, investigations have been based on the paradigm that molecular mediators of OPN functions are two classes of receptors, namely integrins and CD44. The recent finding of an additional cell receptor, i.e., ICOSL, opens a new scenario in which OPN may modulate the function of all of the cell types expressing ICOSL, and this interaction may be functionally modulated by ICOS.
Understanding how OPN is processed and interacts with its natural ligands is of paramount importance for elucidating the complex role that this protein plays in human diseases.
Herein, in this Commemorative Issue, authors are invited to review recent work or submit original studies in all areas of recent and current OPN research, with an emphasis on work providing molecular insight, including, but not limited to, novel physiological and pathological functions, or regulatory mechanisms.
Thus, let us stop counting OPN years and start making them count!
Dr. Giuseppe Cappellano
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Related Special Issue
- 30 Years of OPN Milestones and Future Avenues in Biomedicines (8 articles)