Special Issue "Sepsis: Pathophysiology and Early Diagnostics"

Dear Colleagues,

Sepsis, a life-threatening condition triggered by an overwhelming immune response to infection, remains the leading cause of death in hospitalized patients and continues to present a significant global health challenge. Recent advancements have shed light on novel pathophysiological pathways, emphasizing the importance of endotheliopathy and microvascular dysfunction. Furthermore, sepsis and non-infection-induced systemic inflammatory response syndrome have similar clinical symptoms but differ in treatment and prognosis, and the high mortality rate makes early diagnosis especially important. However, there are currently no definitive biomarkers to accurately predict sepsis development or outcome.

The current focus remains on gaining insight into underlying disease mechanisms and providing new diagnostics for early detection of patients with sepsis. In light of these advancements, we are pleased to announce a Special Issue of Biomedicines, inviting authors to submit their original research, communications, and review articles. We encourage contributions on a wide range of topics, including, but not limited to:

• Immune response dysregulation in sepsis: unraveling the mechanisms;
• Novel pathophysiological pathways: bridging the gap between bench and bedside;
• Sepsis biomarkers: advancements and clinical applications;
• Antibiotic stewardship;
• Endothelium, endothelial glycocalyx, and microcirculatory dysregulation in sepsis;
• Distinct subtypes of sepsis: implications for personalized treatment;
• Clinical trials in sepsis: paving the way for evidence-based interventions.

Dr. Alexandros Rovas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• biomarkers
• infection
• organ dysfunction
• endothelial dysfunction
• organ dysfunction
• glycocalyx
• cytokine storm
• dysregulated immune response