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Biomedicines
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Functional Products Used in Alleviation of Oxidative Stress Diseases and...
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Functional Products Used in Alleviation of Oxidative Stress Diseases and Interaction with Human Microbiota 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 18620

Special Issue Editor

Prof. Dr. Emanuel Vamanu

E-Mail Website
Guest Editor
Faculty of Biotechnology, University of Agricultural Sciences and Veterinary Medicine, 011464 Bucharest, Romania
Interests: microbiota; oxidative stress; in vitro; antioxidant; natural compounds; fermentation; healthy beverages; vegan supplements; non dairy products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Functional products (such as probiotics, prebiotics, dietary fibers, plant extracts, etc.) are useful tools in reducing or alleviating the pathological effects of oxidative stress. Moreover, postbiotics and parapostbiotics have emerged as new products for modulating microbiota bioactivity. The development of innovative products is a significant research area that is providing evidence for disease control and the prevention of degenerative pathologies. Thus, for this Special Issue, we aim to publish recent studies presenting possible in vitro and in vivo evidence of a modulation response through the microbiota pattern. You are also invited to contribute research based on the effect of different drugs that are used in degenerative pathologies and possible interactions with the human microbiota. Side effects are significant in disease management and interactions with associated pathologies. We would like to encourage you to send papers on these and other related aspects relevant to the issue.

Prof. Dr. Emanuel Vamanu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • product administration
  • functional quality
  • microbiota modulation
  • pathology–microbiota
  • immunomodulatory effects
  • polyphenols
  • pro-, pre-, synbiotic nutraceuticals
  • postbiotics
  • parapostbiotics
  • drugs
  • free radicals
  • antioxidant

Published Papers (4 papers)

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Research

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18 pages, 2634 KiB  
Article
Lactobacillus Strains for Vegetable Juice Fermentation—Quality and Health Aspects
by Catalina Voaides, Oana Boiu-Sicuia, Florentina Israel-Roming, Medana Zamfir, Silvia Simona Grosu-Tudor, Iulia Roxana Angelescu and Calina Petruta Cornea
Biomedicines 2022, 10(11), 2867; https://doi.org/10.3390/biomedicines10112867 - 09 Nov 2022
Cited by 2 | Viewed by 1958
Abstract
Vegetable juices are new carrier variants for beneficial bacteria, representing an alternative to dairy-fermented products, especially for vegan, strict vegetarian, or allergic consumers. The aim of this study was to characterize several Romanian native lactic acid bacteria (LAB) strains to select valuable nutritional [...] Read more.
Vegetable juices are new carrier variants for beneficial bacteria, representing an alternative to dairy-fermented products, especially for vegan, strict vegetarian, or allergic consumers. The aim of this study was to characterize several Romanian native lactic acid bacteria (LAB) strains to select valuable nutritional and probiotic strains for vegetable juice fermentation. Nineteen LAB strains were analyzed for antibiotic susceptibility (disc-diffusion method), the presence of antibiotic resistance genes, the presence of functional genes. and the production of organic acids by HPLC. Antibiotic resistant strains were observed only with ampicillin (Amp10) and kanamycin (K30), 79% and 32%, respectively, with results partially confirmed by molecular analysis. Multiplex PCR revealed the presence of LBA1272, dltD, folP, agl, α-amy, malL, and ribA genes, related to stress resistance, starch metabolism, and production of vitamins, except for folK. HPLC analyses were performed on beet roots (SF), tomato (TM), and a mixture of carrots, celery, and beet (MTS) juices. High values of lactic acid were recorded in all cases of LAB fermentation (5034–14,176 µg/mL). The maximum values recorded for acetic acid did not exceed 2.5 mg/mL having a positive influence on the product’s taste. Full article
(This article belongs to the Special Issue Functional Products Used in Alleviation of Oxidative Stress Diseases and Interaction with Human Microbiota 2.0)
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Review

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25 pages, 3247 KiB  
Review
Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging
by Tariq Aziz, Abad Ali Nadeem, Abid Sarwar, Ishrat Perveen, Nageen Hussain, Ayaz Ali Khan, Zubaida Daudzai, Haiying Cui and Lin Lin
Biomedicines 2023, 11(2), 354; https://doi.org/10.3390/biomedicines11020354 - 26 Jan 2023
Cited by 13 | Viewed by 2573
Abstract
Aging is a multifunctional physiological manifestation. The nasal cavity is considered a major site for easy and cost-effective drug and vaccine administration, due to high permeability, low enzymatic activity, and the presence of a high number of immunocompetent cells. This review article primarily [...] Read more.
Aging is a multifunctional physiological manifestation. The nasal cavity is considered a major site for easy and cost-effective drug and vaccine administration, due to high permeability, low enzymatic activity, and the presence of a high number of immunocompetent cells. This review article primarily focuses on aging genetics, physical parameters, and the use of nanoparticles as delivery systems of drugs and vaccines via the nasal cavity. Studies have identified various genes involved in centenarian and average-aged people. VEGF is a key mediator involved in angiogenesis. Different therapeutic approaches induce vascular function and angiogenesis. FOLR1 gene codes for folate receptor alpha protein that helps in regulating the transport of vitamin B folate, 5-methyltetrahydrofolate and folate analogs inside the cell. This gene also aids in slowing the aging process down by cellular regeneration and promotes healthy aging by reducing aging symptoms. It has been found through the literature that GATA 6, Yamanaka factors, and FOLR1 work in synchronization to induce healthy and delayed aging. The role and applications of genes including CBS, CISD, SIRT 1, and SIRT 6 play a significant role in aging. Full article
(This article belongs to the Special Issue Functional Products Used in Alleviation of Oxidative Stress Diseases and Interaction with Human Microbiota 2.0)
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22 pages, 2022 KiB  
Review
Therapeutic Antiaging Strategies
by Shailendra Kumar Mishra, Vyshnavy Balendra, Josephine Esposto, Ahmad A. Obaid, Ricardo B. Maccioni, Niraj Kumar Jha, George Perry, Mahmoud Moustafa, Mohammed Al-Shehri, Mahendra P. Singh, Anmar Anwar Khan, Emanuel Vamanu and Sandeep Kumar Singh
Biomedicines 2022, 10(10), 2515; https://doi.org/10.3390/biomedicines10102515 - 08 Oct 2022
Cited by 10 | Viewed by 10814
Abstract
Aging constitutes progressive physiological changes in an organism. These changes alter the normal biological functions, such as the ability to manage metabolic stress, and eventually lead to cellular senescence. The process itself is characterized by nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, [...] Read more.
Aging constitutes progressive physiological changes in an organism. These changes alter the normal biological functions, such as the ability to manage metabolic stress, and eventually lead to cellular senescence. The process itself is characterized by nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. These hallmarks are risk factors for pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. Emerging evidence has been focused on examining the genetic pathways and biological processes in organisms surrounding these nine hallmarks. From here, the therapeutic approaches can be addressed in hopes of slowing the progression of aging. In this review, data have been collected on the hallmarks and their relative contributions to aging and supplemented with in vitro and in vivo antiaging research experiments. It is the intention of this article to highlight the most important antiaging strategies that researchers have proposed, including preventive measures, systemic therapeutic agents, and invasive procedures, that will promote healthy aging and increase human life expectancy with decreased side effects. Full article
(This article belongs to the Special Issue Functional Products Used in Alleviation of Oxidative Stress Diseases and Interaction with Human Microbiota 2.0)
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16 pages, 1338 KiB  
Review
Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis
by Laura-Dorina Dinu, Ionela Avram, Diana-Roxana Pelinescu and Emanuel Vamanu
Biomedicines 2022, 10(10), 2392; https://doi.org/10.3390/biomedicines10102392 - 25 Sep 2022
Cited by 4 | Viewed by 2651
Abstract
Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. [...] Read more.
Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. The current work comprehensively summarizes the benefits and potential applications of postbiotics and essential mineral-enriched biomass and proposes a new strategy for microbial therapy—mineral-enriched postbiotics. We hypothesize and critically review the relationship between micronutrients (calcium, magnesium, iron, zinc, selenium) and postbiotics with gut microbiota, which has been barely explored yet, and how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis. Additionally, the bioactive molecules and minerals from postbiotics could influence the host mineral status, directly or through gut microbiota, which increases the mineral bioavailability. The review increases our understanding of the health improvements of mineral-enriched postbiotics, including antioxidant functions, highlighting their perspective on microbial therapy to prevent and threaten gut-related diseases. Full article
(This article belongs to the Special Issue Functional Products Used in Alleviation of Oxidative Stress Diseases and Interaction with Human Microbiota 2.0)
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