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Biomedicines
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Biomarkers of Endometriosis
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Biomarkers of Endometriosis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 2973

Special Issue Editors

Dr. Iveta Yotova

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
Interests: endometriosis; lncRNAs; imprinting; epigenetics; biomarkers
Dr. Quanah J. Hudson

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
Interests: endometriosis; lncRNAs; imprinting; epigenetics; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis is a common gynecological disease which affects the quality of life and fertility of many women worldwide. The severity and types of symptoms are variable and often not specific to the disease, making definitive diagnosis difficult without laparoscopic surgery. Hence, there is a need for biomarkers that can diagnose the disease, classify the disease sub-type or severity and have some prognostic or predictive value to allow for earlier and more appropriate treatment for individual patients. In this Special Issue, we invite the contribution of manuscripts related to endometriosis biomarkers to address these topics. 

Dr. Iveta Yotova
Dr. Quanah J. Hudson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • biomarkers
  • diagnostic
  • prognostic

Published Papers (3 papers)

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Research

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12 pages, 966 KiB  
Article
Effects of Progestin on Modulation of the Expression of Biomarkers in Endometriosis
by Daniela Roxana Matasariu, Alexandra Irma Gabriela Bausic, Cristina Elena Mandici, Iuliana Elena Bujor, Alexandra Elena Cristofor, Elvira Bratila, Ludmila Lozneanu, Lucian Vasile Boiculese, Mihaela Grigore and Alexandra Ursache
Biomedicines 2023, 11(7), 2036; https://doi.org/10.3390/biomedicines11072036 - 20 Jul 2023
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Abstract
Background: Our study aimed to examine the osteopontin (OPN) serum levels and tissue expression of CD44 and OPN in endometriosis-affected women both undergoing and not undergoing progestin treatment, and also to determine their involvement in the pathogenesis of endometriosis. Methods: Using an ELISA [...] Read more.
Background: Our study aimed to examine the osteopontin (OPN) serum levels and tissue expression of CD44 and OPN in endometriosis-affected women both undergoing and not undergoing progestin treatment, and also to determine their involvement in the pathogenesis of endometriosis. Methods: Using an ELISA kit, we evaluated the OPN serum levels of healthy and endometriosis-affected women both undergoing and not undergoing progestin treatment. Immunohistochemical (IHC) analyses were used to assess the endometriotic tissue expressions of CD44 and OPN. Results: There were statistically significant higher OPN serum levels in the healthy control group compared to the women with endometriosis. Furthermore, there were higher OPN serum levels in the endometriosis-affected women undergoing the progestin treatment, but the difference did not reach statistical significance. In comparison to OPN, CD44 expression was significantly higher in all the endometriotic tissue glands and stroma, regardless of the patient’s treatment status. Compared to the group receiving therapy, the OPN levels were higher in the endometriosis group not receiving therapy. OPN’s robust cytoplasmic expression seemed to be associated with the non-treatment group. Conclusion: Endometriosis, CD44, and OPN appear to be closely related. This study suggests that endometriosis that has not been treated has an immunological profile distinct to endometriosis that has received treatment. Full article
(This article belongs to the Special Issue Biomarkers of Endometriosis)
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Review

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27 pages, 1114 KiB  
Review
The Pathological Role of miRNAs in Endometriosis
by Mst Ismat Ara Begum, Lin Chuan, Seong-Tshool Hong and Hee-Suk Chae
Biomedicines 2023, 11(11), 3087; https://doi.org/10.3390/biomedicines11113087 - 17 Nov 2023
Viewed by 1193
Abstract
Association studies investigating miRNA in relation to diseases have consistently shown significant alterations in miRNA expression, particularly within inflammatory pathways, where they regulate inflammatory cytokines, transcription factors (such as NF-κB, STAT3, HIF1α), and inflammatory proteins (including COX-2 and iNOS). Given that endometriosis (EMS) [...] Read more.
Association studies investigating miRNA in relation to diseases have consistently shown significant alterations in miRNA expression, particularly within inflammatory pathways, where they regulate inflammatory cytokines, transcription factors (such as NF-κB, STAT3, HIF1α), and inflammatory proteins (including COX-2 and iNOS). Given that endometriosis (EMS) is characterized as an inflammatory disease, albeit one influenced by estrogen levels, it is natural to speculate about the connection between EMS and miRNA. Recent research has indeed confirmed alterations in the expression levels of numerous microRNAs (miRNAs) in both endometriotic lesions and the eutopic endometrium of women with EMS, when compared to healthy controls. The undeniable association of miRNAs with EMS hints at the emergence of a new era in the study of miRNA in the context of EMS. This article reviews the advancements made in understanding the pathological role of miRNA in EMS and its association with EMS-associated infertility. These findings contribute to the ongoing pursuit of developing miRNA-based therapeutics and diagnostic markers for EMS. Full article
(This article belongs to the Special Issue Biomarkers of Endometriosis)
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Other

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18 pages, 1534 KiB  
Systematic Review
Circulating microRNAs as Non-Invasive Biomarkers in Endometriosis Diagnosis—A Systematic Review
by Arne Vanhie, Ellen Caron, Eveline Vermeersch, Dorien O, Carla Tomassetti, Christel Meuleman, Pieter Mestdagh and Thomas M. D’Hooghe
Biomedicines 2024, 12(4), 888; https://doi.org/10.3390/biomedicines12040888 - 17 Apr 2024
Viewed by 401
Abstract
The aim of this systematic review is to assess the power of circulating miRNAs as biomarkers as a diagnostic tool in endometriosis. In endometriosis-suspected women with uncertain imaging, the only way to confirm or exclude endometriosis with certainty is currently laparoscopy. This creates [...] Read more.
The aim of this systematic review is to assess the power of circulating miRNAs as biomarkers as a diagnostic tool in endometriosis. In endometriosis-suspected women with uncertain imaging, the only way to confirm or exclude endometriosis with certainty is currently laparoscopy. This creates a need for non-invasive diagnostics. We searched the literature through the PubMed database using the Mesh terms ‘endometriosis’ and ‘miRNAs’. Some, but limited, overlap was found between the 32 articles included, with a total of 20 miRNAs reported as dysregulated in endometriosis in two or more studies. MiR-17-5p was reported as dysregulated in six studies, followed by miR-451a and let-7b-5p in four studies and miR-20a-5p, miR-143-3p, miR-199a-5p and miR-3613-5p in three studies. Furthermore, a possible impact of the menstrual phase on miRNA expression was noted in five studies, while no influence of hormonal intake was observed in any included study. The modest reproducibility between studies may be attributable to biological variability as well as to the lack of universal protocols, resulting in pre- and analytical variability. Despite the identification of several suitable candidate biomarkers among the miRNAs, the need for high-quality studies with larger and well-defined population cohorts and the use of standardized protocols lingers. Full article
(This article belongs to the Special Issue Biomarkers of Endometriosis)
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