Special Issue "PD-1/PD-L1 and Immunotherapy"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 93

Special Issue Editors

Dr. Cole Peters
E-Mail Website
Guest Editor
Pediatric Hematology-Oncology, University of California, Los Angeles, CA 90024, USA
Interests: oncolytic virology; immunotherapy; pediatric sarcoma
Dr. Fares Nigim
E-Mail Website
Guest Editor
Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA
Interests: neurology; neuropathology; neurosurgery; brain tumors
Dr. Praveen K. Bommareddy
E-Mail Website
Guest Editor
Replimune Inc., Woburn, MA, USA
Interests: oncolytic virology; immunotherapy

Special Issue Information

Dear Colleagues,

The discovery of programmed cell death protein (PD-1) and its ligand’s (PD-L1) role in the inhibition of T cell function is one of the notable milestones in cancer research, achieved during the last two decades. Development of antibodies and small molecule inhibitors to disrupt the PD-1/PD-L1 signaling pathways has not only validated the field of immunotherapy in cancer research, but also identified other T cell checkpoint pathways that impact anti-tumor immune responses. As a testament to their success, checkpoint inhibitors are now standard of care for multiple tumor types, with many others being tested in clinical trials. Despite the effectiveness of anti-PD-1/PD-L1 therapy across many tumor types, there are still tumors that are either resistant to these treatments or relapse after a brief initial response. A large portion of current immunotherapy research is focused on investigating this tumor resistance.

This Special Issue aims to cover the historical development of the PD-1/PD-L1 checkpoint inhibitors and their successes in clinical trials. We will also discuss studies on patients who fail to respond to checkpoint therapy, and their immunologically silent tumors. For these resistant tumors, many groups are attempting to develop complementary antibodies targeting alternative inhibitory immune checkpoints, or trying to find ways to utilize the immunostimulatory character of oncolytic virus immunotherapy or gene therapies to enhance T cell priming and anti-tumor immune response. The study of anti-PD-1 resistance is relatively a new research field, offering new avenues for expanding the literature for those interested in immunotherapy research.

Dr. Cole Peters
Dr. Fares Nigim
Dr. Praveen K. Bommareddy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • programmed cell death protein-1
  • programmed death ligand-1
  • PD1/PDL1
  • immunotherapy
  • oncolytic virus

Published Papers

This special issue is now open for submission.
Back to TopTop